Two Flavonoids From Stem Bark ofCasimiroa edulisand Their Antidiabetic and Antioxidant Activities

Methoxy 13C NMR Chemical Shift as a Molecular Descriptor in the Structural Analysis of Flavonoids and Other Phenolic Compounds

“…Inconsistent chemical shifts for OMe signals were reported for flavonoids of Casimiroa edulis identified as 6,7-dimethoxyflavone [61.9 (7-OMe), 57.2 (6-OMe)] and 56,2´-trimethoxyflavone [61.9 ( 2´-OMe), 57.3 (5-OMe), 55.7 (6-OMe)]. 71 Based on the above discussion, it is evident that the OMe chemical shift plays an important part in the understanding of the molecular structure of methoxylated/oxygenated flavonoids. Although the use of OMe shifts in elucidating structure has a long history, it is surprising that many authors have not taken this as a criterion for structure elucidation.…”

“…Inconsistent chemical shifts for OMe signals were reported for flavonoids of Casimiroa edulis identified as 6,7-dimethoxyflavone [61.9 (7-OMe), 57.2 (6-OMe)] and 56,2´-trimethoxyflavone [61.9 (2´-OMe), 57.3 (5-OMe), 55.7 (6-OMe)]. 71…”

Natural products isolated from Casimiroa

“…The result showed antidepressant-like activity on hexane extract. Further studies reported antidiabetic and antioxidant activities of compounds 7, 9, 42, and 45, isolated from C. edulis using the DPPH radical scavenging assay and the yeast α-glucosidase assay [37,38]. Moreover, the leaves, seeds, and nonedible fruit's parts extracts of C. edulis have been studied for their biological effects, including antihypertensive, vasorelaxant, antioxidant, anti-inflammatory, antitumor, relaxant, and contractile effect in vitro [18,103,104] Natural products isolated from Casimiroa  791 that essential oils extracted from C. pringlei displayed significant sedative and anxiolytic properties in rats.…”