A novel 3D computational model was developed for the turbulent particulate two-phase flow simulation in the rectangular channel. The model is based on the Eulerian approach applied to 3D Reynolds-averaged Navier–Stokes modeling and statistical Probability Distribution Function method. The uniqueness of the method lies in the direct calculation of normal and transverse components of the Reynolds stresses for both gas and particles. Two cases were examined: a conventional channel flow and grid-generated turbulence flow. The obtained numerical results have been verified and validated by the experimental data, received from the turbulent particle dispersion test. The computed values of the particles’ turbulent dispersion and the maximum value of the particulate concentration distribution show good agreement with the experimental results. The examples are ranged from coal and other bulk material pneumatic transport, vertical fluidized beds, coal gasifiers, and chemical reactors.