1969
DOI: 10.1172/jci106182
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Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions

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Cited by 583 publications
(205 citation statements)
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“…Even the glycine angles are within or near energetically stable conformations. Only Asn 14 and Lys 96 show clear left-handed ␣-helical character ( , : 59.9°, 36.0°and 49.9°, 37.1°, respectively). These two residues occur in turns between elements of secondary structure connecting the first ␤-strand to the following ␣-helix and the seventh and eighth ␤-strands.…”
Section: Model and Map-mentioning
confidence: 99%
See 1 more Smart Citation
“…Even the glycine angles are within or near energetically stable conformations. Only Asn 14 and Lys 96 show clear left-handed ␣-helical character ( , : 59.9°, 36.0°and 49.9°, 37.1°, respectively). These two residues occur in turns between elements of secondary structure connecting the first ␤-strand to the following ␣-helix and the seventh and eighth ␤-strands.…”
Section: Model and Map-mentioning
confidence: 99%
“…In addition to fatty acids, their CoA esters, and lysophosphatidic acid, LFABP also binds heme, squalene, certain eicosanoids, bilirubin, and a host of other hydrophobic compounds (3,4,(11)(12)(13)(14). Whether LFABP binds cholesterol is uncertain.…”
mentioning
confidence: 99%
“…Vol. 175 Transferase B, the predominant transferase in rat liver, is identical with ligandin, previously known as Y-protein, azocarcinogen-binding protein and cortisol-metabolite binder I (Litwack et al, 1971); a role for this protein in the uptake, retention and/or secretion of organic anions by liver and kidney has been proposed (Levi et al, 1969). In addition, transferase B can act as a glutathione peroxidase (Burk et al, 1977;Prohaska & Ganther, 1977) and a 3-oxo A5-steroid isomerase (Benson et al, 1977).…”
mentioning
confidence: 99%
“…L-FABP also binds other hydrophobic molecules such as lysophospholipids, 1 eicosanoids, 3,4 bile acids, 5 bilirubin, 6 and heme. 7 It is thus possible that L-FABP in the circulation transports these ligands into PTC via a megalin-mediated uptake pathway.…”
Section: Discussionmentioning
confidence: 99%
“…L-FABP was also shown to bind with other hydrophobic molecules such as lysophospholipids, 2 eicosanoids, 3,4 bile acids, 5 bilirubin, 6 heme, 7 carcinogenic agents 8 and hypolipidemic drugs. 9 When L-FABP was purified from the liver or intestine of rats, it was bound to endogenous ligands with high affinity and only dissociated from them under stringent hydrophobic conditions.…”
mentioning
confidence: 99%