Two heteropolysaccharides from Isaria cicadae Miquel differ in composition and potentially immunomodulatory activity

Xu, Zhanchi; Yan, Xiaoteng; Song, Zihui; Li, Wei; Zhao, Weibo; Ma, Huanhuan; Du, Jiali; Li, Shijie; Zhang, Danyan

doi:10.1016/j.ijbiomac.2018.05.164

Cited by 39 publications

(21 citation statements)

References 25 publications

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“…Zhang et al [ 7 ] found that a C. cicadae polysaccharide exerted its antibacterial activity through damaging cell walls and membranes, increasing the permeability of cell membranes. Xu et al [ 11 ] compared the pharmacological activity of two polysaccharides from C. cicadae (JCH-1 and JCH-2), and found that the immunomodulatory activity of JCH-1 with low molecular weight was more potent than that of JCH-2 with high molecular weight. In a follow-up study, it was demonstrated that JCH-1 could active RAW264.7 cells via toll-like receptor 4 (TLR4) mediated mitogenactivated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathway [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides from Spores of Cordyceps cicadae Protect against Cyclophosphamide-Induced Immunosuppression and Oxidative Stress in Mice

Zheng

et al. 2022

Foods

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This study investigated the purification, preliminary structure and in vivo immunomodulatory activities of polysaccharides from the spores of Cordyceps cicadae (CCSP). The crude CCSP was purified by diethylaminoethyl (DEAE)-cellulose and Sephadex G-100 chromatography, affording CCSP-1, CCSP-2 and CCSP-3 with molecular weights of 1.79 × 106, 5.74 × 104 and 7.93 × 103 Da, respectively. CCSP-2 consisted of mannose and glucose, while CCSP-1 and CCSP-3 are composed of three and four monosaccharides with different molar ratios, respectively. CCSP-2 exhibited its ameliorative effects in cyclophosphamide-induced immunosuppressed mice through significantly increasing spleen and thymus indices, enhancing macrophage phagocytic activity, stimulating splenocyte proliferation, improving natural killer (NK) cytotoxicity, improving bone marrow suppression, regulating the secretion of cytokines and immunoglobulins, and modulating antioxidant enzyme system. These results indicate that CCSP-2 might be exploited as a promising natural immunomodulator.

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Section: Introductionmentioning

confidence: 99%

Polysaccharides from Spores of Cordyceps cicadae Protect against Cyclophosphamide-Induced Immunosuppression and Oxidative Stress in Mice

Zheng

et al. 2022

Foods

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“…To date, many effective anti-cancer formulas have been derived from these herbs, under the guidance of the traditional Chinese medicine (TCM) theory [5,6,7]. The TCM entomogenous Isaria cicadae is an edible entomogenous fungus, formed in cicada nymphs infected by Paecilomyces cicadae, and has been widely used to prevent and treat various diseases [8,9]. In China, it has been used for medicinal and edible purposes for more than 1000 years.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Action and Mechanism of Ergosterol Peroxide from Paecilomyces cicadae Fermentation Broth

Shi

Liu

et al. 2018

IJMS

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Isaria cicadae, a medicinal food fungus, is a fruit from Paecilomyces cicadae. In this study, we purified ergosterol peroxide (EP) from the fermentation broth of P. cicadae and investigated its effects on renal cell carcinoma (RCC) cells, in vitro. EP was purified from P. cicadae fermentation broth. The human RCC cell line 786-0 was used to analyze the anticancer mechanism of EP and inhibit its effect on cancer cell proliferation, in vitro. EP with a validated structure showed a yield rate of 20.1 mg/L and a purity of 96%. EP significantly inhibited RCC cell growth and clone formation in vitro. In addition, EP suppressed the migration and invasion, triggered the apoptosis, and modulated the cell cycle of RCC cells, in a dose-dependent manner. It also downregulated β-catenin expression. EP could be routinely produced through P. cicadae. It fights RCC cells in vitro through multiple mechanisms, including suppressing cell growth, colonization, migration, and invasion, arresting the cell cycle, attenuating β-catenin pathways, and triggering apoptosis.

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“…As a traditional Chinese medicine, I. cicadae has been used for a long time in the form of powders or decoction . A few chemical constituents were isolated and purified from the mycelia and the liquid culture filtrate, which were mainly polysaccharides (Xu et al 2018). Furthermore, the significance of I. cicadae as a potential therapeutic agent for immune diseases such as cancer, allergy, and parasitic disease has also been highlighted (Takano et al 2005;Sun et al 2017).…”

Section: Comparison Between Ic-1 and Apam In Flocculating Activitymentioning

confidence: 99%

High Flocculation of Coal Washing Wastewater Using a Novel Bioflocculant from Isaria cicadae GZU6722

Zou

Sun

et al. 2020

Polish Journal of Microbiology

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Chanhua (Isaria cicadae) was known as a rare entomogenous fungus with various pharmacological activities since a long time ago in China, which has attracted considerable attention. However, less knowledge was maintained about its products as potential bioflocculants. In this work, a bioflocculant IC-1 produced by Isaria cicadae GZU6722, consisted mainly of protein (4%) and polysaccharides including neutral sugars (52.75%) and galacturonic acid (38.14%), was characterized. It presented high efficiency in flocculating coal washing wastewater, and the flocculating efficiency could reach 91.81% by addition of 24 mg l–1 IC-1 compared to the addition of 60 mg l–1 APAM (anionic polyacrylamide) under the same treatment conditions. The highest flocculating efficiency reached 95.8% in the presence of 2% CaCl2. Compared to APAM, the flocculating efficiency of coal washing wastewater by IC-1 varied little with the increasing dosage. Although the flocs in the APAM-assisted sediment were larger than that in the IC-1-assisted sediment after 1 min of sedimentation, few flocs were still found in the supernatant of both treated samples after 10 min of sedimentation. More interestingly, it was observed under the microscope that the flocs in the IC-1-assisted sediments were more compact than that in the APAM-assisted sediments, suggesting that polymer bridging might take place after IC-1 was added into the coal washing wastewater. The evaluation of costs indicated that the use of IC-1 to treat the coal-washing wastewater may be an economical and feasible way to avoid the extra cost for post-treatment of conventional flocculants.

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Two heteropolysaccharides from Isaria cicadae Miquel differ in composition and potentially immunomodulatory activity

Cited by 39 publications

References 25 publications

Polysaccharides from Spores of Cordyceps cicadae Protect against Cyclophosphamide-Induced Immunosuppression and Oxidative Stress in Mice

Polysaccharides from Spores of Cordyceps cicadae Protect against Cyclophosphamide-Induced Immunosuppression and Oxidative Stress in Mice

Anticancer Action and Mechanism of Ergosterol Peroxide from Paecilomyces cicadae Fermentation Broth

High Flocculation of Coal Washing Wastewater Using a Novel Bioflocculant from Isaria cicadae GZU6722

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