Two is better than one: Deuterium in analytical mass spectrometry

Bąchor, Remigiusz; Modzel, Maciej; Cebrat, Marek; Kijewska, Monika; Waliczek, Mateusz; Kuczer, Mariola; Biernat, Monika; Stefanowicz, Piotr; Kluczyk, Alicja

doi:10.1016/j.trac.2024.117842

TrAC Trends in Analytical Chemistry

2024

DOI: 10.1016/j.trac.2024.117842

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Two is better than one: Deuterium in analytical mass spectrometry

Remigiusz Bąchor,

Maciej Modzel,

Marek Cebrat

et al.

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Synthesis of N-(3-Acyloxyacyl)glycines, Small Molecules with Potential Role in Gut Microbiome-Endocannabinoidome Communication

Villano,

Di Marzo

2024

Molecules

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The synthesis of some N-(3-acyloxyacyl)glycines, an interesting class of bioactive gut microbiota metabolites, is described. This procedure involves seven reaction steps using the commercially available Meldrum’s acid to obtain highly pure products, in normal or deuterated form. The key point of the synthetic strategy was the use of commendamide t-butyl ester as a synthetic intermediate, a choice that allowed the removal of the protecting group at the end of the synthetic procedure without degrading of the other ester bond present in the molecule. The developed synthetic sequence is particularly simple, uses readily available reagents and involves a limited number of purifications by chromatographic column, with a reduction in the volume of solvent and energy used.

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Synthesis of N-(3-Acyloxyacyl)glycines, Small Molecules with Potential Role in Gut Microbiome-Endocannabinoidome Communication

Villano,

Di Marzo

2024

Molecules

View full text Add to dashboard Cite

show abstract

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Two is better than one: Deuterium in analytical mass spectrometry

Cited by 1 publication

References 144 publications

Synthesis of N-(3-Acyloxyacyl)glycines, Small Molecules with Potential Role in Gut Microbiome-Endocannabinoidome Communication

Synthesis of N-(3-Acyloxyacyl)glycines, Small Molecules with Potential Role in Gut Microbiome-Endocannabinoidome Communication

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