Two minute walking distance in cystic fibrosis.

Abstract

We have evaluated the 'two minute walking distance' in children with cystic fibrosis as an objective measurement of exercise tolerance. There was a strong correlation between walking distance and height in 89 normal children (r=072). Fifty children with cystic fibrosis showed a similar correlation (r=0-56) with a mean result of 94% of that expected for height compared with the normal children. There was a training effect in the normal children with the second walk being significantly better than the first, but this was not evident in children with cystic fibrosis. The test was reproducible with no significant change in 12 children retested after one to three months. Sixteen children with cystic fibrosis admitted for treatment of chest disease showed a significant improvement in walking distance with treatment. Children as young as 5 years old can perform a walking distance test. It seems to be an objective way of assessing exercise tolerance and can help in evaluating response to treatment.

Building the repertoire of measures of walking in Rett syndrome

“…Alternatively, a two minute walk test (2MWT) has been proposed for populations with more limited capacity to walk [21][22][23]. Good intra-rater and inter-rater reliability of the 2MWT have been described in the elderly and following stroke [23,24] and excellent test-retest has been found in a general population [25].…”

Análise comparativa do teste de caminhada de seis minutos em crianças e adolescentes saudáveis

“…Despite the ATS standardization for the length of the corridor during the test for adults (30.5 meters), some studies have used different lengths in order to make test performance viable [7][8][9] . Li et al 19 conducted a large study on children and adolescents with the aim of establishing reference values for the 6MWT in this population, however the length of the corridor followed the ATS criteria.…”

“…The walked distance is considered a criterion for prognosis of the functional capacity and can be influenced by the length of the corridor 2,8,9 .…”

“…Some of these studies demonstrated the validity and applicability of the 6MWT in heart and respiratory diseases [15][16][17][18] and others in children and adolescents, but the reproducibility criteria were based on the adult population 8,[11][12][13][14]19 .…”

“…Several studies have investigated the applicability and efficiency of the 6MWT in different populations, testing its validity, reliability and interpretability, thus establishing reference values and equations to interpret the test results [8][9][10][11][12][13][14] . Some of these studies demonstrated the validity and applicability of the 6MWT in heart and respiratory diseases [15][16][17][18] and others in children and adolescents, but the reproducibility criteria were based on the adult population 8,[11][12][13][14]19 .…”