1986
DOI: 10.1128/mcb.6.2.380
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Two modes of c-myb activation in virus-induced mouse myeloid tumors.

Abstract: Two modes of disruption of the protooncogene c-myb by viral insertional mutagenesis In mouse myeloid tumor cells are described. The first mode was found in six tumors in which a Moloney murine leukemia virus component had inserted in the same transcriptional orientation upstream of the 5'-most exon with v-myb homology (vEl). cDNA sequence data indicate the presence of a truncated c-myb mRNA that is initiated in the upstream 5' long terminal repeat of the integrated provirus and processed via a cryptic splice d… Show more

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Cited by 126 publications
(113 citation statements)
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“…It is possible that this conservative amino acid change decreases CI DNA binding; however, the Cl-I protein (with Glu^°*) is believed to bind DNA (cited in Paz-Ares et al 1990). This Asp residue is conserved evolutionarily between the various members of the myb oncogene family (Bergmann et al 1981;Klempnauer et al 1982Klempnauer et al , 1986Gonda et al 1985;Boyle et al 1986;Shen-Ong et al 1986;Peter et al 1987) and may occupy a position in the DNA-recognition helix (Ohlendorf et al 1982;Lehming et al 1987;Aggarwal et al 1988;Jordan and Pabo 1988;Otting et al 1988). This conservation suggests that an analogous change in any of the various mammalian or insect myb-homologous domains could also decrease the transcriptional activation function of these proteins dramatically.…”
Section: Discussionmentioning
confidence: 99%
“…It is possible that this conservative amino acid change decreases CI DNA binding; however, the Cl-I protein (with Glu^°*) is believed to bind DNA (cited in Paz-Ares et al 1990). This Asp residue is conserved evolutionarily between the various members of the myb oncogene family (Bergmann et al 1981;Klempnauer et al 1982Klempnauer et al , 1986Gonda et al 1985;Boyle et al 1986;Shen-Ong et al 1986;Peter et al 1987) and may occupy a position in the DNA-recognition helix (Ohlendorf et al 1982;Lehming et al 1987;Aggarwal et al 1988;Jordan and Pabo 1988;Otting et al 1988). This conservation suggests that an analogous change in any of the various mammalian or insect myb-homologous domains could also decrease the transcriptional activation function of these proteins dramatically.…”
Section: Discussionmentioning
confidence: 99%
“…Retrovirus-mediated disruption of the c-myb locus is also oncogenic in mice producing myeloid leukemia (Shen-Ong et al, 1986;Gonda et al, 1987;Shen-Ong and Wolff, 1987;Wolff et al, 1988;Nason-Burchenal and Wolff, 1993). A growing number of genes which can be directly regulated by Myb have been described (reviewed in Ness, 1996), but in neither chickens nor mice are the regulatory targets and pathways known through which this transcription factor promotes tumorigenesis.…”
Section: Introductionmentioning
confidence: 99%
“…2b and c). The overall structure was very similar to that of proviral MoMuLV, although several sequences were different (2,45) (Fig. 2f).…”
Section: Resultsmentioning
confidence: 63%