Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

Early, P.; Rogers, J. H.; Davis, Mark M.; Calame, Kathryn; Bond, Michael D.; Wall, Randolph; Hood, Leroy

doi:10.1016/0092-8674(80)90617-0

Cited by 849 publications

(381 citation statements)

References 21 publications

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“…Many instances of alternative splicing are stochastic and not obviously regulated. Some other cases of alternative splicing appear to be the consequence of different pre-mRNA structures due either to alternative promoter usage (Nabeshima et al, 1984) or alternative poly(A) site usage (Alt et al, 1980;Early et al, 1980). Regulated alternative splicing has been observed for some virus genes during the course of infection (Ziff, 1980).…”

Section: Introductionmentioning

confidence: 99%

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989

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Section: Introductionmentioning

confidence: 99%

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989

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“…Alternative splicing is a process whereby multiple functionally distinct transcripts are encoded from a single gene by the selective removal or retention of exons and/or introns from the maturing RNA [1][2][3][4]. The process is highly regulated, involving trans-acting splicing factors and cis-acting regulatory motifs (see [5] for review) and so is susceptible to hereditary and somatic mutations [6].…”

Section: Introductionmentioning

confidence: 99%

Alternative splicing and the evolution of phenotypic novelty

Bush

Chen

Tovar-Corona

et al. 2017

Phil. Trans. R. Soc. B

169

122

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One contribution of 17 to a theme issue 'Evo-devo in the genomics era, and the origins of morphological diversity'. Alternative splicing, a mechanism of post-transcriptional RNA processing whereby a single gene can encode multiple distinct transcripts, has been proposed to underlie morphological innovations in multicellular organisms. Genes with developmental functions are enriched for alternative splicing events, suggestive of a contribution of alternative splicing to developmental programmes. The role of alternative splicing as a source of transcript diversification has previously been compared to that of gene duplication, with the relationship between the two extensively explored. Alternative splicing is reduced following gene duplication with the retention of duplicate copies higher for genes which were alternatively spliced prior to duplication. Furthermore, and unlike the case for overall gene number, the proportion of alternatively spliced genes has also increased in line with the evolutionary diversification of cell types, suggesting alternative splicing may contribute to the complexity of developmental programmes. Together these observations suggest a prominent role for alternative splicing as a source of functional innovation. However, it is unknown whether the proliferation of alternative splicing events indeed reflects a functional expansion of the transcriptome or instead results from weaker selection acting on larger species, which tend to have a higher number of cell types and lower population sizes.This article is part of the themed issue 'Evo-devo in the genomics era, and the origins of morphological diversity'.

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“…Alternative splicing was first described 35 y ago when it was observed that both secreted and membrane-bound Abs were encoded by the same gene (25,26). Molecular analyses over subsequent decades have demonstrated that alternative splicing influences intracellular localization, protein stability, enzymatic activity, and posttranslational modification (27,28).…”

Section: Discussionmentioning

confidence: 99%

α3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of NK Cells: Correlations with HIV-1 Infection of Cells

Zhang

Lian

Dai

et al. 2017

The Journal of Immunology

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Alternative splicing occurs frequently in many genes, especially those involved in immunity. Unfortunately, the functions of many alternatively spliced molecules from immunologically relevant genes remain unknown. Classical HLA-I molecules are expressed on almost all nucleated cells and play a pivotal role in both innate and adaptive immunity. Although splice variants of HLA-I genes have been reported, the details of their functions have not been reported. In the current study, we determined the characteristics, expression, and function of a novel splice variant of HLA-A11 named HLA-A11svE4. HLA-A11svE4 is located on the cell surface without b2-microglobulin (b2m). Additionally, HLA-A11svE4 forms homodimers as well as heterodimers with HLA-A open conformers, instead of combining with b2m. Moreover, HLA-A11svE4 inhibits the activation of NK cells to protect target cells. Compared with b2m and HLA-A11, the heterodimer of HLA-A11svE4 and HLA-A11 protected target cells from lysis by NK cells more effectively. Furthermore, HLA-AsvE4 expression was upregulated by HIV-1 in vivo and by HSV, CMV, and hepatitis B virus in vitro. In addition, our findings indicated that HLA-A11svE4 molecules were functional in activating CD8 + T cells through Ag presentation. Taken together, these results suggested that HLA-A11svE4 can homodimerize and form a novel heterodimeric complex with HLA-A11 open conformers. Furthermore, the data are consistent with HLA-A11svE4 playing a role in the immune escape of HIV-1.

show abstract

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

Cited by 849 publications

References 21 publications

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

Alternative splicing and the evolution of phenotypic novelty

α3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of NK Cells: Correlations with HIV-1 Infection of Cells

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