Two mutations in the 5′-flanking region of the<i>KITLG</i>gene are associated with litter size of dairy goats

An, Xiaopeng; Hou, Jinxing; Yue, Lei; Gao, Teyang; Song, Yuxuan; Wang, Jianguo; Cao, Binyun

doi:10.1111/age.12277

Cited by 15 publications

(13 citation statements)

References 16 publications

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“…Interestingly, four genes show pleiotropic effects and have been related to phenotypic effects in several livestock species. KITLG has known associations with neural stem cell systems 36 , coat color in mammals 37 , and on litter size in goats 38 . HMGI-C is a major candidate for dwarfism in chickens 39 and MTMR7 is involved in fatty acid composition in pigs 40 .…”

Section: Discussionmentioning

confidence: 99%

Convergent genomic signatures of domestication in sheep and goats

et al. 2018

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The evolutionary basis of domestication has been a longstanding question and its genetic architecture is becoming more tractable as more domestic species become genome-enabled. Before becoming established worldwide, sheep and goats were domesticated in the fertile crescent 10,500 years before present (YBP) where their wild relatives remain. Here we sequence the genomes of wild Asiatic mouflon and Bezoar ibex in the sheep and goat domestication center and compare their genomes with that of domestics from local, traditional, and improved breeds. Among the genomic regions carrying selective sweeps differentiating domestic breeds from wild populations, which are associated among others to genes involved in nervous system, immunity and productivity traits, 20 are common to Capra and Ovis. The patterns of selection vary between species, suggesting that while common targets of selection related to domestication and improvement exist, different solutions have arisen to achieve similar phenotypic end-points within these closely related livestock species.

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Section: Discussionmentioning

confidence: 99%

Convergent genomic signatures of domestication in sheep and goats

et al. 2018

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“…In the current study, nine SNPs in six genes were strongly linked with sheep litter size, confirming their genetic roles in regulating sheep litter size. Previous research found two SNPs in KIT [9] and ten SNPs in KITLG were significantly associated with goat litter size [10,11,12,13]. A mutation in ADAMTS1 was associated with pig litter size [19].…”

Section: Discussionmentioning

confidence: 99%

“…Two single nucleotide polymorphisms (SNPs) in KIT were linked with goat litter size [9]. Similarly, ten loci in KITLG were significantly associated with goat litter size [10,11,12,13]. ADAMTS1 and NOG were crucial for ovulation [14,15,16,17,18] and a mutation in ADAMTS1 was notably linked with litter size in a new Qingping female line [19].…”

Section: Introductionmentioning

confidence: 99%

Association of Polymorphisms in Candidate Genes with the Litter Size in Two Sheep Breeds

Yuan

Zhang

et al. 2019

Animals

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Simple SummaryIncreasing litter size is critical for the intensive sheep production system. Genetic marker-assisted selection (MAS) based on proven molecular indicators could enhance the efficacy of sheep selection with improving litter size traits. Many single nucleotide polymorphisms (SNPs) linked with litter size in Hu sheep and Small-tailed Han sheep have been identified. However, they usually explain a small portion of genetic variation and additional genetic markers linked with litter size have not been found. The present study investigated the potential SNPs in ten genes as candidate markers for improved litter size in sheep. As a result, nine SNPs in six out of ten genes can be served as useful genetic markers to improve the selection of litter size since they are significantly associated with litter size either in Hu sheep or Small-tailed Han sheep. Further, a combined haplotypes analysis of the two loci (LIFR: g.35862868C>T and LIFR: g.35862947G>T) revealed that H2H3 (CTTT) combined haplotypes had the largest litter size than the rest combined haplotypes and more than those with either mutation alone in Small-tailed Han sheep. Our knowledge is essential to implement the MAS in sheep and further to increase the profitability in the sheep industry.AbstractHu sheep and Small-tailed Han sheep are the most widely raised and most famous maternal sheep breeds in China, which are known for precocious puberty, perennial oestrus and high fecundity (1–6 lambs each parity). Therefore, it is crucial to increase litter size of these two breeds for intensive sheep industry. The objective of this study was to identify potential genetic markers linked with sheep litter size located at ten genes. This study collected blood sample of 537 Hu sheep and 420 Small-tailed Han sheep with litter size of first parity. The average litter sizes in Hu sheep and Small-tailed Han sheep were 2.21 and 1.93. DNA-pooling sequencing method was used for detecting the potential single nucleotide polymorphisms (SNPs) in ten genes related to follicle development and female reproduction. SNPscan® was used for individually genotyping. As a result, a total of 78 putative SNPs in nine out of ten candidate genes (except NOG) were identified. In total, 50 SNPs were successfully genotyped in Hu sheep and Small-tailed Han sheep. After quality control, a total of 42 SNPs in Hu sheep and 44 SNPs in Small-tailed Han sheep were finally used for further analysis. Association analysis revealed that nine SNPs within six genes (KIT: g.70199073A>G, KITLG: g.124520653G>C, ADAMTS1: g.127753565T>C, ADAMTS1: g.127754640G>T, NCOA1: g.31928165C>T, NCOA1: g.32140565G>A, LIFR: g.35862868C>T, LIFR: g.35862947G>T and NGF: g.91795933T>C) were significantly associated with litter size in Hu sheep or Small-tailed Han sheep. A combined haplotypes analysis of the two loci (LIFR: g.35862868C>T and LIFR: g.35862947G>T) revealed that H2H3 (CTTT) combined haplotypes had the largest litter size than the rest combined haplotypes and more than those with either mutation alone in Sma...

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“…Using Ensembl to annotate related SNPs, we found a total of 68 genes around signi cant peaks, and identi ed 32 candidate genes associated with egg production according to their functions (Table 3). Some genes such as NELL2, KITLG, GHRHR, NCOA1, ITPR1, GAMT, and CAMK4, which have been proved to be related to egg production, litter size, or reproductive traits, are worth a deeper exploration [19][20][21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Genome Wide Association Studymentioning

confidence: 99%

Identification of Candidate Genomic Regions for Chicken Egg Production Traits Based on Genome Wide Association Study

Zhao

Nie

Zhang

et al. 2021

Preprint

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Background: Since the domestication of chicken, various chicken breeds have been developed for food production, entertainment, and so on. Compared to indigenous chicken breeds which generally do not show elite production performance, commercial breeds or lines are selected intensely for meat or egg production. In the present study, in order to understand the molecular mechanisms underlying the dramatic egg yielding differences between commercial egg-type chickens and indigenous chickens, we performed a genome-wide association study (GWAS) in a mixed linear model. Results: We obtained 148 single nucleotide polymorphisms (SNPs) associated with egg production traits or reproductive traits (57 significantly, 91 suggestively). Among them, 18 SNPs overlapped with previously reported quantitative trait loci (QTL), including 13 for egg production and 5 for reproductive traits. Three SNPs were significantly associated with multiple egg production traits, such as egg number, age at first egg, and egg production rate in chickens. Furthermore, we identified 32 candidate genes based on the function of the screened genes. These genes were found to be mainly involved in regulating hormones, playing a role in the formation, growth, and development of follicles, and in the development of the reproductive system. Some genes such as NELL2, KITLG, GHRHR, NCOA1, ITPR1, GAMT, and CAMK4 deserve our attention and further study since they have been reported to be closely related to reproductive traits. In addition, the most significant genomic region obtained in this study was located at 48.61-48.84Mb on GGA5. In this region, we have repeatedly annotated four genes, in which YY1 and WDR25 have been shown to be related to oocytes and reproductive tissues, respectively, which implies that this region may be a candidate region underlying egg production traits. Conclusion: Our study utilized the genomic information from various chicken breeds or populations differed in egg production to understand the molecular genetic mechanisms involved in reproduction traits. We identified a series of SNPs, candidate genes, or genomic regions that associated with reproductive traits, which could help us in developing egg production in chickens.

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Two mutations in the 5′-flanking region of theKITLGgene are associated with litter size of dairy goats

Cited by 15 publications

References 16 publications

Convergent genomic signatures of domestication in sheep and goats

Convergent genomic signatures of domestication in sheep and goats

Association of Polymorphisms in Candidate Genes with the Litter Size in Two Sheep Breeds

Identification of Candidate Genomic Regions for Chicken Egg Production Traits Based on Genome Wide Association Study

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