Two New 2‐Phenylethyl Alcohol Derivatives and One New Lignan Derivative from the Root of Ilex pubescens

Abstract

The phytochemical investigation of the methanolic extract of the root of Ilex pubescens Hook. et Arn. furnished six compounds including three new compounds, ilexin A (1), ilexin B (2), and ilexin C (3), besides vanillic acid, vanillin, and caffeic acid. Compounds 1 and 2 were identified as 2-phenylethyl alcohol derivatives, while compound 3 is a lignan derivative. The structures of these compounds have been elucidated by the combination of the analysis of NMR and MS data, CD spectra, and chemical evidences.

Systematic study on QAMS method for simultaneous determination of triterpenoid saponins in Ilex pubescens by HPLC and UPLC

“…The saponins were investigated to be the main active component. So far, more than 30 individual saponins in Ilex pubescens have been isolated and identied, [2][3][4] which show activity against hypertension, platelet aggregation, thrombosis, inammatory atherosclerosis, cardiac ischemia, and so on. These inherent saponins work 'synergistically' and could be considered as 'marker compounds' for the chemical evaluation or standardization of Ilex pubescens.…”

Ilexpublesnins C–M, Eleven New Triterpene Saponins from the Roots of Ilex pubescens

“…All the solvents were Abstract ! Eleven new triterpene saponins, ilexpublesnins C-M (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11), along with ten known analogues were isolated from the roots of Ilex pubescens. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments.…”

“…Its roots are commonly used as Chinese herbal medicine for treatment of cardiovascular disease and hypercholestemia in south China [1]. Previous phytochemical investigation on its roots and leaves led to the isolation of triterpene saponins [2], lignan glycosides [3], phenylethanols [4,5], and other minor compounds [6][7][8]. Pharmacological evaluation proved that Ilex pubescens extracts exhibited a variety of bioactivities, i.e., to enlarge blood vessels, improve microcirculation, ease blood pressure, inhibit platelet aggregation, prevent thrombosis, and reduce cardiac ischemia, as well as to decrease the excitation of the cardiac conduction system and other effects [9].…”