Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems

Abstract

Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman’s Method was conducted, kadsuricoccins A and B showed activity with the AChE inhibit index (AII) up to 68.96% ± 0.19% and 57.8% ± 0.11% at 94 nM (compared with positive control tacrine AII 79.80% ± 0.20%, 9.4 nM), respectively.

A Comparative Study on Photo-Protective and Anti-Melanogenic Properties of Different Kadsura coccinea Extracts

“…Kadsura coccinea (KC) has also gained interest in Chinese folk medicine to identify effective treatments for preventing several diseases [ 1 , 2 ]. It is not only consumed as food but also is highly regarded for its pharmacological properties, especially anti-HIV, anti-fungal, anti-lipid peroxidation, anti-hepatitis, anti-inflammatory, and anti-tumor properties [ 3 , 4 ]. Many studies have shown the therapeutic effects of KC such as in treating gastrointestinal disorders and rheumatoid arthritis, calming the heart, strengthening the kidneys, and promoting blood and fluid circulation [ 5 , 6 ].…”

Chemical Composition and Biological Activities of Essential Oils from the Leaves, Stems, and Roots of Kadsura coccinea

“…In particular, lignans [ 2 , 3 , 4 , 5 , 6 ] and triterpenoids [ 7 , 8 , 9 , 10 , 11 , 12 ] from this plant have been received considerable attention. In previous studies, the compounds of K. coccinea have been reported with various activities, including the inhibition of nitric oxide production [ 2 , 13 ], antioxidant [ 14 , 15 ], anti-HIV [ 16 ], anti-inflammatory [ 17 ], hepatoprotective [ 18 ], acetylcholinesterase and butyrylcholinesterase inhibitory activities [ 15 , 19 , 20 ], and other pharmacological effects.…”

Comparative study of the photo‑protective and anti‑melanogenic properties of gomisin D, J and O

“…Based on the properties of photoprotection and melanogenesis, several cosmetic and pharmaceutical candidates with antioxidant, photoprotective and anti-melanogenic effects have been investigated (31,36,37). Dibenzocyclooctadiene lignans are one of the most widely used biologically active compounds extracted from Kadsura medicinal plants in China and other Asian countries (2,38). Studies have confirmed that Kadsura medicinal plants exert various pharmacological effects, including anti-HIV, anti-fungal, anti-lipid peroxidation, anti-hepatitis, anti-inflammatory and antitumor properties, and are widely used in the treatment of rheumatoid arthritis and promoting blood and fluid circulation (39)(40)(41).…”