Two New Alkaloids from the Marine‐Derived Fungus Penicillium sp. LSH‐3‐1

Abstract

Two new alkaloids, peniokaramine (1) and penipyranopyridine (6), along with seven known compounds, were isolated from the marine‐derived fungus Penicillium sp. LSH‐3‐1. Their structures were elucidated from UV, IR, MS, 1D and 2D NMR spectroscopic data. The anti‐inflammatory potential of compounds 1–8 in LPS‐induced RAW264.7 cells was detected, revealing that compounds 3 and 5 significantly decreased LPS‐induced production of pro‐inflammatory mediators, including NO, IL‐6 and TNF‐α. Compounds 1–8 were also screened for their cytotoxic activity against A549 cells and compound 1 showed moderate activity.

Marine natural products

“…240) and alkaloids 744, 745, 240 746, 747. 241 Polyketide derivatives 748-752, were isolated from a Pestalotiopsis strain 242 and tyrosine derivative 753 and terezine derivatives 754 and 755 were obtained from Phoma herbarum. 243 Pseudopithomyces maydicus was the source of aromatic polyketides 756-760 (ref.…”

Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021–2023)

“…LSH-3-1. Peniokaramine (281) showed moderate cytotoxic activity against A549 cells with an inhibition percentage of 53.43 ± 5.89% [89]. Penicidihydropyridones A (283) and B (284) (Figure 6) were isolated from the sponge-derived Penicillium sp.…”