Two new alkaloids from Tibetan medicine of Hypecoum leptocarpum

Hypecoum spp.—Chemistry and Biological Activity of Alkaloids

“…This section summarizes the alkaloid compounds that have been identified in the Hypecoum spp. since 1972 (Table 2) [2,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]27,[40][41][42][43][44][45][46][47][48][49][50]. So far, a total of 86 naturally occurring alkaloids have been reported for ten plant species-H. procumbens, H. procumbens var.…”

“…glaucescens, H. imberbe, H. lactiflorum, H. pendulum, H. trilobum, H. leptocarpum, H. erectum, H. ponticum and H. parviflorum. Based on their structures, the Hypecoum alkaloids can be divided into eight major groups: protopines (1-11), protoberberines (12)(13)(14)(15)(16)(17), benzophenantridines (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28), aporphines (29)(30)(31)(32)(33), simple isoquinolines (34)(35)(36)(37)(38), secoberbines , spirobenzilisoquinolines (67)(68)(69)(70)(71)(72)(73) and others (74-86). Two chemical structures have been detected in the literature with the name leptocarpine-protopine alkaloid 8 and alkaloid 82.…”

“…Both compounds have been identified in H. leptocarpum [10,22,42]. On the other hand, the structure of alkaloid 41 has been published in the literature under two different names, dihydroleptopine and coryximine, isolated from H. leptocarpum [22,23,43]. Similarly, the newly found in H. erectum 2-(1,3-dioxolo [4,5-h]isoquinolin-7-yl)-4,5-dimethoxy-Nmethyl-benzenethanamine has the same structure as the alkaloid leptocarmine (62), isolated from H. leptocarpum [19,23,24].…”

“…The known alkaloids in the genus belong to the various classes of isoquinolines-protopines, protoberberines, benzophenanthridines, aporphines, simple isoquinolines, secoberbines, spirobenzylisoquinolines and others. Protopine is a predominant alkaloid isolated from all investigated plants of the genus [2,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Besides being biologically active compounds, isoquinoline alkaloids are characteristic secondary metabolites in the family Papaveraceae and can be used for chemotaxonomic purposes [25].…”

“…In recent years, more than 40 alkaloids have been identified in Hypecoum species, and new alkaloid structures, along with their pharmacological activities, are reported every year, enriching the diversity of natural compounds. Some of them have promising properties for the treatment of important diseases such as inflammation, cancer and microbial infections [18,19,22,23,[26][27][28][29].…”