Two new antimalarial quassinoid derivatives from the stems of Brucea javanica

Chumkaew, Parinuch; Pechwang, Jaraslak; Srisawat, Theera

doi:10.1007/s11418-017-1089-2

Cited by 18 publications

(3 citation statements)

References 17 publications

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“…Bruceine D ( 303 ) was also isolated from the roots of the plant. Both compounds inhibited P. falciparum K1 strain, but 303 was also cytotoxic against cancerous human KB and NCI-H187 cells [188, 189]. Eurycoma longifolia (Simaroubaceae) root extract yielded the new 18-dehydro-6α-hydroxyeurycomalactone ( 305 ), alongside known eurycomanone ( 306 ) and eurycomanol ( 307 ), with nanomolar antiplasmodial activity [86].…”

Section: Terpenesmentioning

confidence: 99%

“…Eurycoma longifolia (Simaroubaceae) root extract yielded the new 18-dehydro-6α-hydroxyeurycomalactone ( 305 ), alongside known eurycomanone ( 306 ) and eurycomanol ( 307 ), with nanomolar antiplasmodial activity [86]. The bioactivity of quassinoids has been correlated with the presence of an α,β-unsaturated ketone in ring A. Quassinoids possessing an oxymethylene bridge joining C-8 and C-13 have also shown pronounced activity [188]. These two structural features are considered essential for potent antiplasmodial activity but might also be responsible for the cytotoxicity of the compounds.…”

Section: Terpenesmentioning

confidence: 99%

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Antiplasmodial natural products: an update

Tajuddeen

Heerden

2019

Malar J

127

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BackgroundMalaria remains a significant public health challenge in regions of the world where it is endemic. An unprecedented decline in malaria incidences was recorded during the last decade due to the availability of effective control interventions, such as the deployment of artemisinin-based combination therapy and insecticide-treated nets. However, according to the World Health Organization, malaria is staging a comeback, in part due to the development of drug resistance. Therefore, there is an urgent need to discover new anti-malarial drugs. This article reviews the literature on natural products with antiplasmodial activity that was reported between 2010 and 2017.MethodsRelevant literature was sourced by searching the major scientific databases, including Web of Science, ScienceDirect, Scopus, SciFinder, Pubmed, and Google Scholar, using appropriate keyword combinations.Results and DiscussionA total of 1524 compounds from 397 relevant references, assayed against at least one strain of Plasmodium, were reported in the period under review. Out of these, 39% were described as new natural products, and 29% of the compounds had IC50 ≤ 3.0 µM against at least one strain of Plasmodium. Several of these compounds have the potential to be developed into viable anti-malarial drugs. Also, some of these compounds could play a role in malaria eradication by targeting gametocytes. However, the research into natural products with potential for blocking the transmission of malaria is still in its infancy stage and needs to be vigorously pursued.

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Section: Terpenesmentioning

confidence: 99%

Section: Terpenesmentioning

confidence: 99%

Antiplasmodial natural products: an update

Tajuddeen

Heerden

2019

Malar J

127

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“…6 Because of the use of Kniphofia reflexa Hutchinson ex Codd. Asphodelaceae in the treatment of relapsing fevers, supported by literature data on the antiplasmodial activities within classes of natural products like terpenes, [7][8][9][10] flavonoids, [11][12][13] alkaloids, [14][15][16][17] quassinoids, 7,18 xanthones, [19][20][21][22] quinones, and anthraquinones, [23][24][25][26][27][28][29] a needed study of this plant was conducted considering its unique endemic nature, coupled to its classification. To the best of our knowledge, no study is reported on the antiplasmodial and antimalarial potential of chemical constituents of K reflexa.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and in Vivo Evaluation of the Antimalarial Activities of Kniphofia reflexa Hutchinson ex Codd

Sema

Lannang

Zofou

et al. 2022

Natural Product Communications

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In a phytochemical investigation of the rhizomes of Kniphofia reflexa, an endemic plant used to treat relapsing fevers in Kejom, northwestern Cameroon, 12 known (1-12) compounds were obtained following chromatographic methods and purification, together with 3 new derivatives (13-15) prepared by acetylation. One-dimensional and 2-dimensional nuclear magnetic resonance spectroscopic studies together with infrared and ultraviolet spectral analyses in association with data found in the literature were used to determine the structure of the compounds. In the in vitro evaluation of compounds 1-9, 12-14, and the crude extract against Plasmodium falciparum chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains, cassiamin C (1) [IC50 0.57 ± 0.54 (D6); 0.78 ± 0.08 (W2)], and crude extract [IC50 1.06 ± 0.22 (D6); 1.08 ± 0.12 (W2)] were highly active against the parasites. Kniphofiarexine (12) was inactive. However, its derivative, kniphofiarexine B (14), was moderately active. In the in vivo studies, the extract suppressed Plasmodium berghei growth, but did not clear completely the parasites.

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Nature's Armamentarium against Malaria: Antimalarials and Their Semisynthetic Derivatives

Ismail

2018

Nutraceuticals and Natural Product Derivatives

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Two new antimalarial quassinoid derivatives from the stems of Brucea javanica

Cited by 18 publications

References 17 publications

Antiplasmodial natural products: an update

Antiplasmodial natural products: an update

In Vitro and in Vivo Evaluation of the Antimalarial Activities of Kniphofia reflexa Hutchinson ex Codd

Nature's Armamentarium against Malaria: Antimalarials and Their Semisynthetic Derivatives

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