Two new compounds from edible mushroomSarcomyxa edulis

Abstract

Chemical investigation of the edible mushroom Sarcomyxa edulis led to the isolation of one new highly degraded sterol (1), and one new β-carboline alkaloid (2), along with nine known compounds (3-11) for the first time from this mushroom. The structures of new compounds were elucidated using HR-ESI-MS data and NMR spectroscopy. In addition, anti-inflammatory activity of new compounds was evaluated against lipopolysaccharide-induced NO production in RAW 264.7 macrophages. Compound 2 exhibited a good anti-inflammatory activity with IC50 value of 9.88 ± 0.48 μM, and compound 1 exhibited a weak inhibitory effect with IC50 value of 71.36 ± 5.11 μM.

Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup

“…The most recent β-carboline discovered in mushrooms ( 27 , Figure 2 ) was isolated from Sarcomyxa edulis [ 32 ]. Compound 27 is the only reviewed β-carboline with a ketone group located in an exocyclic position.…”

“…Compound 27 is the only reviewed β-carboline with a ketone group located in an exocyclic position. It showed a remarkable anti-inflammatory activity against lipopolysaccharide-induced NO [ 32 ].…”

“…[ 30,31] 1-Acetyl-7-hydroxy-9H-pyrido [3,4-b]indole-3-carboxylic acid (27) Sarcomyxa edulis Anti-inflammatory [32] Subgroup: Pyrroloquinoline alkaloids (Figure 3) Basidiomycetes-X Weak antioxidant [43] Subgroup: Indole alkaloids (Figure 6)…”

“…The synthesis of mycenarubin A (29) was accomplished in 10 steps and produced a 21% total yield by Backenköhler et al (2018) [39]. Later, mycenarrubins D-F (31)(32)(33) were isolated from Mycena haematopus [36]. Mycenarubin A (29) was also obtained from M. haematopus [34] and Mycena pelianthina, with the last species also being a source for the isolation of mycenarubin D (31) [35].…”