Two New Compounds Isolated from the Itea omeiensis and Their Anti‐oxidant Activities

Abstract

Two new compounds (1‐2) together with ten known compounds (3‐12) were isolated for the first time from the 95% EtOH extract of aerial parts of Itea omeinesis. Their structures were elucidated based on extensive spectroscopic analyses and comparison with published data. The structure of 1 was further confirmed through single‐crystal X‐ray diffraction analysis, and circular dichroism (CD) spectrum in combination with acid hydrolysis was employed for the absolute configuration determination of 2. Compound 1 was the first 2‐arylbenzo[b]furan with an extra six‐membered lactone ring from Itea plants. Anti‐oxidant assays indicated that compound 1 possessed significant radical scavenging effects on 1,1‐Diphenyl‐2‐picrylhydrazyl (DPPH) and 2,2'‐Azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS·+) with IC50 values of 0.14 and 0.06 mg/mL, respectively, which were comparable to the positive control of ascorbic acid. However, no obvious anti‐hepatocellular carcinoma activity was observed for compounds 1 and 2.