Two new copper (II) complexes with sulfanilamide as ligand: Synthesis, structural, thermal analysis, electrochemical studies and antibacterial activity

Chebout, Oussama; Trifa, Chahrazed; Bouacida, Sofiane; Boudraa, Mhamed; Habila, Imane; Merzougui, Moufida; Mazouz, Wissam; Ouari, Kamel; Boudaren, Chaouki; Mérazig, Hocine

doi:10.1016/j.molstruc.2021.131446

Cited by 15 publications

(16 citation statements)

References 45 publications

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“…This is in agreement with the fact that the antimicrobial activity of metal complexes can be elucidated on the basis of chelation theory, which suggested that chelation could promote the ability of the complexes to pass through a cell membrane. 13 , 39 , 40 , 80 From the results, the complexes were found to be potential antibacterial agents when compared to the standard drug.…”

Section: Resultsmentioning

confidence: 99%

“…This favors the permeation through the lipid layer of the cell membrane. The increased liposolubility of the ligand upon being complexed with a metal may contribute to the easy transportation into the bacterial cells, which then blocks the metal-binding sites in the enzyme of microorganisms. , Furthermore, different factors should be under consideration for metal complexes having antibacterial activities, viz , chelate effect, nature of the ligands, total charge of the complex, and nature of the ion that neutralizes the given ionic complex. ,,− , …”

Section: Resultsmentioning

confidence: 99%

“…aureus (ATCC25923) and Streptococcus pyogenes (ATCC19615) and Gram-negative Escherichia coli (ATCC 25922), and P. aeruginosa (ATCC 27853) bacteria strains by adopting previously reported media preparation methods. ,,,− The bacterial strains were screened against two sample concentrations (100 and 200 μg/mL) in DMSO using ciprofloxacin as a reference with the same concentrations. The bacterial growths were recorded by measuring the zones of inhibition.…”

Section: Methodsmentioning

confidence: 99%

“…27,38 Furthermore, different factors should be under consideration for metal complexes having antibacterial activities, viz, chelate effect, nature of the ligands, total charge of the complex, and nature of the ion that neutralizes the given ionic complex. 13,27,[38][39][40]80 3.12.2. Antioxidant Activity.…”

Section: Fluorescence Studymentioning

confidence: 99%

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Novel Zinc(II) and Copper(II) Complexes of 2-((2-Hydroxyethyl)amino)quinoline-3-carbaldehyde for Antibacterial and Antioxidant Activities: A Combined Experimental, DFT, and Docking Studies

Damena

Alem

Zeleke³

et al. 2022

ACS Omega

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In the present work, two novel complexes of zinc(II) and copper(II) were synthesized from the ligand 2-((2-hydroxyethyl)amino)quinoline-3-carbaldehyde ( H 2 L ) in a 1:2 metal-to-ligand ratio in methanol. The complexes were characterized by UV–visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (XRD), scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDX), mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, and thermogravimetric analysis (TGA) experimental techniques and density functional theory (DFT) calculations. The spectral data revealed that the mono-deprotonated ( HL ) ligand acted as a bidentate ligand, which bound to both Zn(II) and Cu(II) ions via the nitrogen atom of the amine (N–H) and the hydroxyl (O–H) groups through the deprotonated oxygen atom. Formation constants and thermal analysis indicated that both metal complexes are stable up to 100 °C with thermodynamically favored chemical reactions. The Cu(II) complex showed antibacterial activities with the zones of inhibition of 20.90 ± 2.00 mm against Pseudomonas aeruginosa , 19.69 ± 0.71 mm against Staphylococcus aureus , and 18.58 ± 1.04 mm against Streptococcus pyogenes . These results are relatively higher compared with the Zn(II) complex at the same concentration. The minimum inhibitory concentration (MIC) results for the complexes also showed similar trends against the three bacteria. On the other hand, radical scavenging activities of both Cu(II) and Zn(II) complexes showed half-maximal inhibitory concentrations (IC 50 ) of 4.72 and 8.2 μg/mL, respectively, while ascorbic acid (a positive control) has a value of 4.28 μg/mL. The Cu(II) complex exhibited better communication with the positive control, indicating its potential use for biological activities. The calculated and in silico molecular docking results also strongly support the experimental results.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Fluorescence Studymentioning

confidence: 99%

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Novel Zinc(II) and Copper(II) Complexes of 2-((2-Hydroxyethyl)amino)quinoline-3-carbaldehyde for Antibacterial and Antioxidant Activities: A Combined Experimental, DFT, and Docking Studies

Damena

Alem

Zeleke³

et al. 2022

ACS Omega

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“…The copper(II) complexes were screened in vitro for antibacterial activity against certain pathogenic bacteria [ [31] , [32] , [33] ]. The complexes were found to exhibit considerable activity against Gram –ve and Gram + ve bacteria.…”

Section: Resultsmentioning

confidence: 99%

Multi-target activity of copper complexes: Antibacterial, DNA binding, and molecular docking with SARS-CoV-2 receptor

Arthi

Mahendiran

Kaya

et al. 2023

Chemico-Biological Interactions

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Copper and nickel complexes based on 4-((4-nitrophenyl)diazenyl)-3-(trifluoromethyl)-1H-pyrazol-5-ol; synthesis, characterization, X-ray studies, DFT calculations, molecular docking and antimicrobial activity

Amin,

Diker,

Şahin

et al. 2024

Inorganic Chemistry Communications

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Two new copper (II) complexes with sulfanilamide as ligand: Synthesis, structural, thermal analysis, electrochemical studies and antibacterial activity

Cited by 15 publications

References 45 publications

Novel Zinc(II) and Copper(II) Complexes of 2-((2-Hydroxyethyl)amino)quinoline-3-carbaldehyde for Antibacterial and Antioxidant Activities: A Combined Experimental, DFT, and Docking Studies

Novel Zinc(II) and Copper(II) Complexes of 2-((2-Hydroxyethyl)amino)quinoline-3-carbaldehyde for Antibacterial and Antioxidant Activities: A Combined Experimental, DFT, and Docking Studies

Multi-target activity of copper complexes: Antibacterial, DNA binding, and molecular docking with SARS-CoV-2 receptor

Copper and nickel complexes based on 4-((4-nitrophenyl)diazenyl)-3-(trifluoromethyl)-1H-pyrazol-5-ol; synthesis, characterization, X-ray studies, DFT calculations, molecular docking and antimicrobial activity

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