Two new diarylheptanoids and a new phenylhexanol derivative from the bulbils of Dioscorea opposita Thunb. and their α-glucosidase inhibitory activity

Recent advances on chemical constituents from Dioscorea opposita and their biological activities

“…Liu [17] isolated and identified five phenanthrene constituents from the above-ground parts of Dioscorea opposita, which are 7-hydroxy-2,6dimethoxy-1,4-phenanthrenedione (18), volucrin (19), 6-hydroxy-2,4,7-trimethoxyphenanthrene (batatasin I, 20), and 7-hydroxy2,4,6-trimethoxyphenanthrene (21). In addition, Zhang et al [18] isolated two α-glucosidase inhibitors, identified as batatasin I (20) and 2,4-dimethoxy-6,7-dihydroxyphenanthrene (22), from the skin of Chinese yam using activity-directed isolation. The chemical structures of the above-mentioned stilbenes are shown in Figure 1.…”

“…Cao et al [22] isolated two new diphenylheptanes, which are diosniponols E (23) and F (24), and seven known compounds from yam, namely, diosniponol A (25), diosniponol B (26), (1R,3S,5R)-1,7-bis(4hydroxyphenyl)-1,5-epoxy-hydroxyheptane ( 27), 1,7-bis(4-hydroxyphenyl)heptane-4E,6E-heptadien-3-one (28), (3R,5R)-1,7-bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanediol ( 29), (3S,5S)-1-(4-hydroxyphenyl)-7-(4hydroxy-3-methoxyphenyl)hetane-3,5-diol (30), and (3R,5R)-3,5-dihydroxy-1,7-bis(4hydroxyphenyl)heptane (31). Feng et al [23] isolated a new natural product, which is 5-ethoxy-1,7-…”

“…Cao et al [22] conducted α-glucosidase inhibition activity screening on 10 compounds isolated and identified from Chinese yam. Among them, (2R,4R)-6-(4-hydroxy-3-methoxyphenyl)-hexane-1,2,4-triol and 1,7-bis(4-hydroxyphenyl)heptane-4E,6E-heptadien-3-one showed inhibitory effects on α-glucosidase, with IC50 values of 16.2 ± 2.2 and 8.7 ± 1.6 μM, respectively.…”