Two new lanthanide complexes with 5-(Pyrazol-1-yl)nicotinic acid: Structures and their anti-cancer properties

Zhu, Xingye; Li, Zhipeng; Ji, Xiaoxi; Qing, Chen; Wu, Shuangyan; Gao, Enjun

doi:10.1016/j.jinorgbio.2021.111505

Journal of Inorganic Biochemistry

2021

DOI: 10.1016/j.jinorgbio.2021.111505

|View full text |Cite

Two new lanthanide complexes with 5-(Pyrazol-1-yl)nicotinic acid: Structures and their anti-cancer properties

Xingye Zhu

Zhipeng Li

Xiaoxi Ji

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

2024

Publication Types

Select...

Article5

Relationship

Self Cite1

Independent4

Authors

Journals

Cited by 6 publications

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Synthesis and anticancer activities of novel Pt (II) and Pd (II) complexes with 4‐(2,2′:6′,2″‐terpyridin‐4′‐yl)phenol as ligand

Yao

et al. 2023

Applied Organom Chemis

Self Cite

View full text Add to dashboard Cite

Traditional platinum (Pt)‐based drugs have limited use in cancer treatment because of their toxicity, which generates the need for new Pt complexes with effective anticancer activity. Two potent prospective anticancer small molecule drug complexes, PtLCl (1) and PdLCl (2) (L:4‐[2,2′:6′,2′‐terpyridin‐4′‐yl]phenol), were synthesized via a low‐temperature solvothermal method. The structures of the complexes are characterized by a four‐coordinated rhombus plane, according to single‐crystal X‐ray diffraction studies. The complexes 1 and 2 were further characterized using several techniques including powder X‐ray diffraction, infrared spectroscopy, and cyclic voltammetry. Cytotoxicity was assessed using flow cytometry and morphological observations of HeLa cells. The findings demonstrate that both complexes were highly effective at inducing cell death, and the tumor inhibition rate of 1 was greater than that of 2, with total tumor inhibition of 92.3% and 72.3%, respectively, after 24 h. In addition, fluorescence and UV–vis spectroscopy showed that these complexes interacted with DNA through the embedding methods. The four‐coordinated planar structure and π–π stacking could prevent DNA transfer and replication, which has the potential for more effective cancer cell eradication through intercalation. Therefore, these two complexes are promising candidates for the development of new Pt‐ and Pd‐based anticancer drugs.

show abstract

Synthesis and anticancer activities of novel Pt (II) and Pd (II) complexes with 4‐(2,2′:6′,2″‐terpyridin‐4′‐yl)phenol as ligand

Yao

et al. 2023

Applied Organom Chemis

Self Cite

View full text Add to dashboard Cite

show abstract

Two La(III) complexes containing pyridine-2,6-dicarboxylate as in vitro potent cytotoxic agents toward human lymphocyte cells

Abdolmaleki

Aliabadi

Ghadermazi

2022

Inorganica Chimica Acta

View full text Add to dashboard Cite

Synthesis, characterization, and cytotoxicity of Pt (Ⅱ) and Pd (Ⅱ) complexes with 2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline as ligand

Yu,

Kang,

et al. 2024

Inorganica Chimica Acta

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Two new lanthanide complexes with 5-(Pyrazol-1-yl)nicotinic acid: Structures and their anti-cancer properties

Cited by 6 publications

References 36 publications

Synthesis and anticancer activities of novel Pt (II) and Pd (II) complexes with 4‐(2,2′:6′,2″‐terpyridin‐4′‐yl)phenol as ligand

Synthesis and anticancer activities of novel Pt (II) and Pd (II) complexes with 4‐(2,2′:6′,2″‐terpyridin‐4′‐yl)phenol as ligand

Two La(III) complexes containing pyridine-2,6-dicarboxylate as in vitro potent cytotoxic agents toward human lymphocyte cells

Synthesis, characterization, and cytotoxicity of Pt (Ⅱ) and Pd (Ⅱ) complexes with 2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline as ligand

Contact Info

Product

Resources

About