Two New Nitrogen-Containing Glycosides From Stixis scandens

Abstract

Phytochemical investigation of a methanol extract of Stixis scandens stems and leaves led to the isolation of 3 nitrogen-containing compounds (1-3) and 6 phenolics (4-9), which included 2 new glycosides, one a phenolic amide glucoside, scandemide (1), and the other an indole alkaloid glycoside, stixilenin (2). Their structures were elucidated by spectroscopic (1D- and 2D-NMR) and spectrometric (HR-ESI-MS) analyses, and acid hydrolysis. The isolated compounds were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW264.7 cells.

Recent Development of a Traditional Herbal Medicine, Stixis suaveolens (Roxb.) Pierre: Its Botany, Ethnomedicine, Phytochemistry, Pharmacology, and Toxicology

“…The different parts of Stixis species are used in folk medicine to treat rheumatism, arthralgia, and eye diseases. 4,5 In previous studies, isolated compounds, including alkaloids, 6 L-stachydrine, flavonoids, lignans, phenolic amides, 7 glucosinolates, 8 and other compounds, were found in Stixis species. Recently, modern pharmacological reports showed that extracts and phytocompounds of Stixis species exhibited various pharmacological effects such as anti-inflammatory, 7 antiviral effects, 9 etc.…”

“…The primary distribution of S. suaveolens species includes China (Guangdong, West Guangxi, Hainan, South Xizang, South Yunnan, and Southwest Yunnan), Northeast India, Bangladesh, Bhutan, Myanmar, Nepal, North and Northeast Thailand, Cambodia, Laos, and Northwest Vietnam (Lai Chau, Son La, and Ha Giang). [4][5][6][7][8][9][10]18,19 Morphologically, the woody vines of S. suaveolens are 1.0 to 15.0 m tall. Twigs are stout, terete, light red, and have smooth hair.…”

“…The flowering season is from April to May, and the fruit season is from August to October. [4][5][6][7][8][9][10]20,21 Ethnotraditional Uses Various species of Stixis Lour., including S. suaveolens and S. scandens Lour. (Syn., Stixis elongata Baill., Stixis flavescens Baill., Stixis manipurensis Deb & Rout, Stixis parviflora (Griff.)…”

“…2,22,23 Among them, 2 common species, namely S. suaveolens and S. scandens, have been reported to be used to treat various diseases in traditional medicine in some countries like Vietnam, Bangladesh, and India. 4,5,7,9,24,25 All parts of herb plants can be used medicinally, and they have a long tradition of alternative medicine for various ailments. Due to the potential benefits of the phytomedicines from S. suaveolens, different parts of this species, including roots, stem bark, leaves, and fruits, are used in traditional systems of medicine in India, Bangladesh, and Vietnam for countless ailments.…”

Stixis scandensleaf extract-loading ZnO nanoparticles for porcine epidemic diarrhea virus (PEDV) treatment

“…A 2023 publication showed two new N-containing glycoside compounds in the composition of Stixis scandens leaves. 12 A similar plant, Stixis suaveolens Roxb, in the same family, has been studied for some of its chemical components. 13 From the Stixis suaveolens Roxb plant, Vietnamese scientists have developed a method to extract the compound Cappariloside A.…”