Two New S-Phase-Specific Genes fromSaccharomyces cerevisiae

Le, Siyuan; Davis, Colleen; Konopka, James B.; Sternglanz, Rolf

doi:10.1002/(sici)1097-0061(19970915)13:11<1029::aid-yea160>3.0.co;2-1

Cited by 211 publications

(187 citation statements)

References 52 publications

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“…1A). Consistent with a role for Asf1 in chromatin assembly during NER, yeast asf1 mutants are sensitive to UV irradiation [36].…”

Section: Chromatin Assembly During Excision Repairmentioning

confidence: 57%

“…Yeast lacking Asf1, CAF-1 or INO80 activity have profound viability problems in response to DNA damaging agents [13,36,38,41,43]. A closer examination of the cell cycle stage where the CAF-1 and asf1 mutants yeast die following double-strand DNA repair shows that they permanently arrest at metaphase due to activation of the DNA damage checkpoint leading to cell death [41,94] (our unpublished observations).…”

Section: The Consequences Of Failure To Assemble and Disassemble Chromentioning

confidence: 77%

“…Inactivation in Saccharomyces cerevisiae causes sensitivity to UV, alkylating agents [36], radiomimetics [13], the HO endonuclease [37], and gamma irradiation [38].…”

Section: Asf1mentioning

confidence: 99%

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Chromatin disassembly and reassembly during DNA repair

Linger

Tyler

2007

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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Current research is demonstrating that the packaging of the eukaryotic genome together with histone proteins into chromatin is playing a fundamental role in DNA repair and the maintenance of genomic integrity. As is well established to be the case for transcription, the chromatin structure dynamically changes during DNA repair. Recent studies indicate that the complete removal of histones from DNA and their subsequent reassembly onto DNA accompanies DNA repair. This review will present evidence indicating that chromatin disassembly and reassembly occur during DNA repair and that these are critical processes for cell survival after DNA repair. Concomitantly, candidate proteins utilized for these processes will be highlighted.

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“…1A). Consistent with a role for Asf1 in chromatin assembly during NER, yeast asf1 mutants are sensitive to UV irradiation [36].…”

Section: Chromatin Assembly During Excision Repairmentioning

confidence: 57%

Section: The Consequences Of Failure To Assemble and Disassemble Chromentioning

confidence: 77%

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Chromatin disassembly and reassembly during DNA repair

Linger

Tyler

2007

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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“…Another histone chaperone, Asf1, is associated with the HIR complex (Green et al 2005). Null mutants in components of the HIR complex do not have a growth phenotype (Sherwood et al 1993), but asf1D cells grow poorly (Le et al 1997).…”

Section: Negative Regulation Of the Histone Genesmentioning

confidence: 99%

Regulation of Histone Gene Expression in Budding Yeast

Eriksson¹,

Ganguli²,

Nagarajavel³

et al. 2012

Genetics

116

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We discuss the regulation of the histone genes of the budding yeast Saccharomyces cerevisiae. These include genes encoding the major core histones (H3, H4, H2A, and H2B), histone H1 (HHO1), H2AZ (HTZ1), and centromeric H3 (CSE4). Histone production is regulated during the cell cycle because the cell must replicate both its DNA during S phase and its chromatin. Consequently, the histone genes are activated in late G1 to provide sufficient core histones to assemble the replicated genome into chromatin. The major core histone genes are subject to both positive and negative regulation. The primary control system is positive, mediated by the histone gene-specific transcription activator, Spt10, through the histone upstream activating sequences (UAS) elements, with help from the major G1/S-phase activators, SBF (Swi4 cell cycle box binding factor) and perhaps MBF (MluI cell cycle box binding factor). Spt10 binds specifically to the histone UAS elements and contains a putative histone acetyltransferase domain. The negative system involves negative regulatory elements in the histone promoters, the RSC chromatin-remodeling complex, various histone chaperones [the histone regulatory (HIR) complex, Asf1, and Rtt106], and putative sequence-specific factors. The SWI/SNF chromatin-remodeling complex links the positive and negative systems. We propose that the negative system is a damping system that modulates the amount of transcription activated by Spt10 and SBF. We hypothesize that the negative system mediates negative feedback on the histone genes by histone proteins through the level of saturation of histone chaperones with histone. Thus, the negative system could communicate the degree of nucleosome assembly during DNA replication and the need to shut down the activating system under replication-stress conditions. We also discuss post-transcriptional regulation and dosage compensation of the histone genes.

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“…Asf1 was first identified in a genetic screen based on its ability to disrupt transcriptional silencing in budding yeast when overexpressed (Le et al, 1997). Later, it was shown that Asf1 was a histone chaperone functioning in both replication-coupled and replicationindependent nucleosome assembly (Tyler et al, 1999).…”

Section: The Function Of Three Histone Chaperones In Rc Nucleosome Asmentioning

confidence: 99%

Histones, histone chaperones and nucleosome assembly

Burgess

Zhang

2010

Protein Cell

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Chromatin structure governs a number of cellular processes including DNA replication, transcription, and DNA repair. During DNA replication, chromatin structure including the basic repeating unit of chromatin, the nucleosome, is temporarily disrupted, and then reformed immediately after the passage of the replication fork. This coordinated process of nucleosome assembly during DNA replication is termed replication-coupled nucleosome assembly. Disruption of this process can lead to genome instability, a hallmark of cancer cells. Therefore, addressing how replication-coupled nucleosome assembly is regulated has been of great interest. Here, we review the current status of this growing field of interest, highlighting recent advances in understanding the regulation of this important process by the dynamic interplay of histone chaperones and histone modifications.

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Two New S-Phase-Specific Genes fromSaccharomyces cerevisiae

Cited by 211 publications

References 52 publications

Chromatin disassembly and reassembly during DNA repair

Chromatin disassembly and reassembly during DNA repair

Regulation of Histone Gene Expression in Budding Yeast

Histones, histone chaperones and nucleosome assembly

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