Two new secolignans from the roots of Urtica mairei Levl.

Wei, Wang; Yan, Xing; Duan, Li; Zhou, Yuan; Tang, Ling; Wang, Yong Qi; Feng, Bao Min

doi:10.1016/j.cclet.2008.06.049

Cited by 12 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, U. dioica roots (methanol extracts) were able to inhibit aromatase (AR) and 5a-reductase (5aRE) in a dose-dependent manner (ED 50 of 3.58 and 14.7 mg/mL, respectively). Urtica mairei (roots) reduced BPH and inhibited the activity of 5a-reductase ( Table 13 ) [ 114 , 115 ].…”

Section: Pharmacological Activities Of the Genus Urticamentioning

confidence: 99%

Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Taheri

Quispe

Herrera‐Bravo

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Urtica dioica belongs to the Urticaceae family and is found in many countries around the world. This plant contains a broad range of phytochemicals, such as phenolic compounds, sterols, fatty acids, alkaloids, terpenoids, flavonoids, and lignans, that have been widely reported for their excellent pharmacological activities, including antiviral, antimicrobial, antihelmintic, anticancer, nephroprotective, hepatoprotective, cardioprotective, antiarthritis, antidiabetic, antiendometriosis, antioxidant, anti-inflammatory, and antiaging effects. In this regard, this review highlights fresh insight into the medicinal use, chemical composition, pharmacological properties, and safety profile of U. dioica to guide future works to thoroughly estimate their clinical value.

show abstract

Section: Pharmacological Activities Of the Genus Urticamentioning

confidence: 99%

Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Taheri

Quispe

Herrera‐Bravo

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Secolignans may derive from a matairesinol-type lignan precursor ( 51 ) through an intramolecular rearrangement that transfers the phenyl group of one monomer unit on to the α-carbon of the second monomer unit. To date, secolignans have only been found in the angiosperm genera Peperomia (Monache and Compagnone, 1996), Justicia (Kavitha et al, 2003), and Urtica (Wang et al, 2008), suggesting yet another case of independent occurrences of similar metabolic traits in distantly related species.…”

Section: Lignansmentioning

confidence: 99%

Chemodiversity in Selaginella: a reference system for parallel and convergent metabolic evolution in terrestrial plants

Weng

Noel

2013

Front. Plant Sci.

View full text Add to dashboard Cite

Early plants began colonizing the terrestrial earth approximately 450 million years ago. Their success on land has been partially attributed to the evolution of specialized metabolic systems from core metabolic pathways, the former yielding structurally and functionally diverse chemicals to cope with a myriad of biotic and abiotic ecological pressures. Over the past two decades, functional genomics, primarily focused on flowering plants, has begun cataloging the biosynthetic players underpinning assorted classes of plant specialized metabolites. However, the molecular mechanisms enriching specialized metabolic pathways during land plant evolution remain largely unexplored. Selaginella is an extant lycopodiophyte genus representative of an ancient lineage of tracheophytes. Notably, the lycopodiophytes diverged from euphyllophytes over 400 million years ago. The recent completion of the whole-genome sequence of an extant lycopodiophyte, S. moellendorffii, provides new genomic and biochemical resources for studying metabolic evolution in vascular plants. 400 million years of independent evolution of lycopodiophytes and euphyllophytes resulted in numerous metabolic traits confined to each lineage. Surprisingly, a cadre of specialized metabolites, generally accepted to be restricted to seed plants, have been identified in Selaginella. Initial work suggested that Selaginella lacks obvious catalytic homologs known to be involved in the biosynthesis of well-studied specialized metabolites in seed plants. Therefore, these initial functional analyses suggest that the same chemical phenotypes arose independently more commonly than anticipated from our conventional understanding of the evolution of metabolism. Notably, the emergence of analogous and homologous catalytic machineries through convergent and parallel evolution, respectively, seems to have occurred repeatedly in different plant lineages.

show abstract