Two new sesquiterpenes produced by the endophytic fungus <i>Aspergillus fumigatus</i> from <i>Ligusticum wallichii</i>

Li, Sha; Chen, Jinfeng; Qin, Ling-Ling; Li, Xiaohua; Cao, Zhixing; Gu, Yu‐Cheng; Guo, Da‐Le; Deng, Yun

doi:10.1080/10286020.2018.1540606

Cited by 29 publications

(18 citation statements)

References 13 publications

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“…Because of the high frequency of A. fumigatus isolation from tulip bulbs, there might be certain mechanisms by which A. fumigatus colonizes and infects the plant tissue, enabling persistence across bulb progenies. Notably, some A. fumigatus strains were isolated from Citrus macrocarpa, Myricaria laxiflora, Ligusticum wallichii , and Moringa oleifera (Francisco et al, 2020, Qin et al, 2019, Li et al, 2020, Arora and Kaur, 2019) as an endophyte. In general, however, the view that A. fumigatus has an endophytic mode in its life cycle remains to be established.…”

Section: Discussionmentioning

confidence: 99%

Intimate genetic relationships and fungicide resistance in multiple strains of human pathogenic fungus Aspergillus fumigatus isolated from a plant bulb

Takahashi

Oiki

Kusuya

et al. 2021

Preprint

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Fungal infections are increasingly dangerous because of environmentally-dispersed resistance to antifungal drugs. Azoles are commonly used antifungal drugs, but they are also used as fungicides in agriculture, which may enable enrichment of azole-resistant strains of the human pathogen Aspergillus fumigatus in the environment. Understanding of environmental dissemination and enrichment of genetic variation associated with azole resistance in A. fumigatus is required to suppress resistant strains. Here, we focused on eight strains of azole-resistant A. fumigatus isolated from a single tulip bulb for sale in Japan. This set includes strains with TR34/L98H/T289A/I364V/G448S and TR46/Y121F/T289A/S363P/I364V/G448S mutations in the cyp51A gene, which showed higher tolerance to several azoles than strains harboring TR46/Y121F/T289A mutation. The strains were typed by microsatellite typing, single nucleotide polymorphism profiles, and mitochondrial and nuclear genome analyses. The strains grouped differently using each typing method, suggesting historical genetic recombination among the strains. Our data also revealed that some strains isolated from the tulip bulb showed tolerance to other classes of fungicide, such as QoI and carbendazim, followed by related amino acid alterations in the target proteins. Considering spatial-temporal factors, plant bulbs are an excellent environmental niche for fungal strains to encounter partners, and to obtain and spread resistance-associated mutations.

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Section: Discussionmentioning

confidence: 99%

Intimate genetic relationships and fungicide resistance in multiple strains of human pathogenic fungus Aspergillus fumigatus isolated from a plant bulb

Takahashi

Oiki

Kusuya

et al. 2021

Preprint

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“…laxiflora (T) China Tang et al. (2019) SW620 08.63 ± 0.15 μM HCT116 09.03 ± 0.61 μM CaCo2 12.56 ± 0.91 μM SMMC-7721 27.66 ± 0.88 μM A-549 37.06 ± 2.24 μM MCF-7 27.89 ± 0.70 μM Isopenicin B (68) SW480 11.60 ± 0.18 μM SW620 15.48 ± 1.39 μM HCT116 14.95 ± 0.22 μM CaCo2 20.34 ± 0.25 μM SMMC-7721 33.49 ± 0.17 μM MCF-7 33.05 ± 0.19 μM Sesquiterpenoids Fumagillene A (69) MV4-11 8.40 ± 2.9 μg/mL Aspergillus fumigatus Ligusticum wallichii (T) China Li et al. (2020c) MDA-MB-231 14.3 ± 5.8 μg/mL Fumagillene B (70) MV4-11 11.2 ± 3.6 μg/mL MDA-MB-231 17.3 ± 6.4 μg/mL Proversilin C (71) HL-60 7.30 ± 1.2 μM Aspergillus versicolor F210 Lycoris radiata (T) China Li et al.…”

Section: Cytotoxic Secondary Metabolites From Endophytic Fungimentioning

confidence: 99%

“…Two novel sesquiterpenes named , Fumagillene A (69) and Fumagillene B (70) were separated from EtOAc extract of endophytic fungi Aspergillus fumigatus isolated from the root of Ligusticum wallichii . Compound (69) exhibited cytotoxicity against MDA-ME-231 and MV4-11 cancer cell lines with IC 50 s of 8.4 ± 2.9 and 4.3 ± 5.8 μg/ml, while compound (70) showed activity at 11.2 ± 3.6 and 17.3 ± 6.4 μg/ml respectively ( Li et al., 2020c ). Proversilin C (71) and Proversilin E (72) are unprecedented drimane-type sesquiterpenoids which were obtained from fungi Aspergillus versicolor F210, an endophyte associated with Lycoris radiata .…”

Section: Cytotoxic Secondary Metabolites From Endophytic Fungimentioning

confidence: 99%

Endophytic fungi: A treasure trove of novel anticancer compounds

Prajapati

Goswami

Rawal

2021

Current Research in Pharmacology and Drug Discovery

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Cancer is a multifactorial disease with a convoluted genesis and progression. The emergence of multidrug resistance to presently be offered drug and relapse is by far, the most critical concern to tackle this deteriorating disease. Henceforth, there is undeniably an inflated necessity for safe, promising, and less harmful new anticancer drugs. Natural compounds from various sources like plants, animals, and microorganisms have occupied a center stage in drug discovery due to their tremendous chemical diversity and potential as therapeutic agents. Endophytic microbes are symbiotically associated with plants and have been proven to produce novel or analogues of host bioactive metabolites exhibiting a variety of biological activities including anticancer activity. This review emphasizes on structurally diverse unprecedented anticancer natural compounds that have been reported exclusively from endophytic fungi from 2016 to 2020. It covers chemical nature of metabolites, its fungal source associated with terrestrial, as well as marine plants and anticancer activity based on their cytotoxicity profile against various cancer cell lines. Many of these fungal metabolites with promising anticancer activity can be used as lead molecules for in silico experiments and deserve special attention from scientists for further in vitro and clinical research.

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“…Fumagillene A ( 20 ) showed moderate growth inhibition against the cancer cell lines MDA‐ME‐231 and MV4‐11 with IC 50 values of 14.3 ± 5.8 and 8.4 ± 2.9 μg ml −1 , respectively. Fumagillene B ( 21 ) also exhibited moderate inhibition against MDA‐ME‐231 and MV4‐11 with IC 50 values of 17.3 ± 6.4 and 11.2 ± 3.6 μg ml −1 (Li et al 2020c).…”

Section: Introductionmentioning

confidence: 99%

The endophytic Aspergillus strains: A bountiful source of natural products

Hagag

Abdelwahab

El-kader

et al. 2022

Journal of Applied Microbiology

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Fungi that invade plant inner tissues without inducing disease symptoms are known as fungal endophytes. They represent a promising and tremendous reservoir of natural products with valuable biological potentials for application in medicine, agriculture and industry. Among the numerous existing endophytic fungi, Aspergillus strains constitute one of the most prolific sources of secondary metabolites with diverse chemical classes and interesting biological activities. This review covers the literature of the year 2020, reporting the isolation of 202 compounds obtained from more than 10 different endophytic Aspergillus species associated with different host plants. Analysis and interpretation of the collected data revealed that chemical investigation of endophytes belonging to the genus Aspergillus may greatly contribute to the discovery of potential drug leads. The isolated metabolites were chemically various and exhibited diverse biological activities such as antibacterial, anti‐cancer, anti‐plasmodial, anti‐inflammatory, antioxidant, immunosuppressive and antifungal activities. Moreover, adoption of advanced technology in molecular biology together with modern chemical tools is anticipated to improve the discovery of new biopharmaceuticals from this valuable microbial world in the future.

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Two new sesquiterpenes produced by the endophytic fungus Aspergillus fumigatus from Ligusticum wallichii

Cited by 29 publications

References 13 publications

Intimate genetic relationships and fungicide resistance in multiple strains of human pathogenic fungus Aspergillus fumigatus isolated from a plant bulb

Intimate genetic relationships and fungicide resistance in multiple strains of human pathogenic fungus Aspergillus fumigatus isolated from a plant bulb

Endophytic fungi: A treasure trove of novel anticancer compounds

The endophytic Aspergillus strains: A bountiful source of natural products

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