Two New Terpenes from the Lichen Parmelia perlata

Abdullah, Sumaiyah; Hamid, Hinna; Ali, Mazhar; Ansari, S. H.; Alam, Mohammad Mahboob

doi:10.1002/chin.200722182

Cited by 9 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are in line with this information and suggest that the antioxidant activity of some tested extracts might be attributable to the presence of nonphenolic compounds. For instance, apart from phenols, phytochemical analysis of lichens has revealed the presence of terpenoids in different Parmeliaceae species [39], and these minor compounds have demonstrated to possess antioxidant properties and therefore to contribute to the total antioxidant activity [40]. Besides, it should be pointed out that individual phenolics may present distinct antioxidant activities in the different chemical tests, and there may be synergistic or antagonistic interactions between phenolics and other compounds like proteins, carbohydrates, and so forth.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Antioxidant Capacities and Cytotoxic Effects of Ten Parmeliaceae Lichen Species

Fernández-Moriano

González-Burgos

Divakar³

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Parmeliaceae represents the largest and widespread family of lichens and includes species that attract much interest regarding pharmacological activities, due to their production of unique secondary metabolites. The current work aimed to investigate the in vitro antioxidant and cytotoxic activities of the methanol extracts of ten Parmeliaceae species, collected in different continents. Methanol extraction afforded high phenolic content in the extracts. The antioxidant activity displayed by lichens was evaluated through chemical assays, such as the ORAC (Oxygen Radical Absorbance Capacity) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities and the ferric reducing antioxidant power (FRAP). A moderately positive correlation was found between the phenolic content and the antioxidant properties for all the species: R: 0.7430 versus ORAC values, R: 0.7457 versus DPPH scavenging capacity, and R: 0.7056 versus FRAP reducing power. The methanol extract of Flavoparmelia euplecta exhibited the highest ORAC value, the extract of Myelochroa irrugans showed the maximum DPPH scavenging capacity, and Hypotrachyna cirrhata methanol extract demonstrated the highest reducing power. Further, the cytotoxic activity of the ten species was investigated on the human cancer cell lines HepG2 and MCF-7; Myelochroa irrugans exhibited the highest anticancer potential. The pharmacological activities shown here could be attributed to their phytochemical constituents.

show abstract

Section: Resultsmentioning

confidence: 99%

Evaluation of the Antioxidant Capacities and Cytotoxic Effects of Ten Parmeliaceae Lichen Species

Fernández-Moriano

González-Burgos

Divakar³

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Terpenes In recent years, more data indicate the presence of terpenes in numerous representatives of lichens (Culberson 1970;Rundel 1978;Abdullah et al 2007). One of the many functions of these compounds is their antimicrobial activity, but the mechanism of action of terpenes on microorganisms is not fully understood (Cowan 1999).…”

Section: Antimicrobial Activity and Probable Mechanisms Of Action Of mentioning

confidence: 99%

Lichen Secondary Metabolites

Ranković¹

2015

109

View full text Add to dashboard Cite

“…Previous phytochemical analysis of P. perlatum exposed the presence of atranorin, lecanoric acid, orcin, erythrolein, azolitmin, spaniolitmint, flavonoids, saponins, tannins, glycosides, steroidal aglycone, carbohydrates, oligodynamic elements usnic acid, atronin, salazinic acid, tridecylmyristate, proto-lichesteric acid, 3-ketooleanane, icosan-1ol, lecanoric acid, labdane type diterpenoid; named permelandone, and lano-2-en-type triterpene; named permelanostene [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

The Spasmolytic, Bronchodilator, and Vasodilator Activities of Parmotrema perlatum Are Explained by Anti-Muscarinic and Calcium Antagonistic Mechanisms

et al. 2021

View full text Add to dashboard Cite

Parmotremaperlatumis traditionally used in different areas of Pakistan to treat gastrointestinal, respiratory, and vascular diseases. This study evaluates the underlying mechanisms for traditional uses of P. perlatumin diarrhea, asthma, and hypertension. In vitro pharmacological studies were conducted using isolated jejunum, trachea, and aortic preparations, while the cytotoxic study was conducted in mice. Crude extract of P. perlatum(Pp.Cr), comprising appreciable quantities of alkaloids and flavonoids, relaxed spontaneously contracting jejunum preparation, K+ (80 mM)-induced, and carbachol (1 µM)-induced jejunum contractions in a concentration-dependent manner similar to dicyclomine and dantrolene. Pp.Cr showed a rightward parallel shift of concentration-response curves (CRCs) of Cch after a non-parallel shift similarto dicyclomine and shifted CRCs of Ca+2 to rightward much likeverapamil and dantrolene, demonstrating the coexistence of antimuscarinic and Ca+2 antagonistic mechanism. Furthermore, Pp.Cr, dicyclomine, and dantrolene relaxed K+ (80 mM)-induced and Cch (1 µM)-induced tracheal contractions and shifted rightward CRCs of Cch similar to dicyclomine, signifying the dual blockade. Additionally, Pp.Cr also relaxed the K+ (80 mM)-induced and phenylephrine (1 µM)-induced aortic contraction, similarly to verapamil and dantrolene, suggesting Ca+2 channel antagonism. Here, we explored for the first time thespasmolytic and bronchodilator effects of Pp.Crand whether they maybe due to the dual blockade of Ca+2 channels and muscarinic receptors, while the vasodilator effect might be owing to Ca+2 antagonism. Our results provide the pharmacological evidence that P. perlatumcould be a new potential therapeutic option to treat gastrointestinal, respiratory, and vascular diseases. Hence, there is a need for further research to explore bioactive constituent of P. perlatumas well as further investigation by suitable experimental models are required to further confirm the importance and usefulness of P. perlatumin diarrhea, asthma, and hypertension treatment.

show abstract

Two New Terpenes from the Lichen Parmelia perlata

Cited by 9 publications

References 0 publications

Evaluation of the Antioxidant Capacities and Cytotoxic Effects of Ten Parmeliaceae Lichen Species

Evaluation of the Antioxidant Capacities and Cytotoxic Effects of Ten Parmeliaceae Lichen Species

Lichen Secondary Metabolites

The Spasmolytic, Bronchodilator, and Vasodilator Activities of Parmotrema perlatum Are Explained by Anti-Muscarinic and Calcium Antagonistic Mechanisms

Contact Info

Product

Resources

About