Two Novel and Efficient Approaches to Synthesis of Enantiopure Dipeptide β‐Turn Mimetics: Indolizidinone Amino Acids

Abstract

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Peptide Science: Exploring the Use of Chemical Principles and Interdisciplinary Collaboration for Understanding Life Processes

“…Our most recent efforts are directed toward bicyclic heterocyclic systems that constrain putative β-turns both in φ-ψ space and in χ space. [177][178][179][180][181][182] The challenge of exploring all the available topographical space with 16, 32, or even more isomers is substantial, but certainly can be aided by combinatorial chemistry such as the one-bead, one-compound method. 183 .…”