Two Novel Diterpenoids, Erinacines H and I from the Mycelia of <i>Hericium erinaceum</i>

Lee, Eun Woo; Shizuki, Kazue; Hosokawa, Satoshi; Suzuki, Masami; Suganuma, Hiroyuki; Inakuma, Takahiro; Li, Jingxuan; Ohnishi‐Kameyama, Mayumi; Nagata, Takayuki; Furukawa, Shoei; Kawagishi, Hirokazu

doi:10.1271/bbb.64.2402

Cited by 150 publications

(110 citation statements)

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“…Hericenones C-H (8,9,12) and erinacines A-I (10,11,15), compounds promoting nerve growth factor (NGF) synthesis in cultured astrocytes, were isolated from the fruiting body and mycelium of H. erinaceus, respectively. NGF primarily acts on cholinergic neurons in the central nervous system and has potent biological effects, such as the induction of neuronal differentiation, the promotion of neuronal survival, and regeneration (20).…”

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Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

et al. 2011

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The mushroom Hericium erinaceus has been used as a food and herbal medicine since ancient times in East Asia. It has been reported that H. erinaceus promotes nerve growth factor secretion in vitro and in vivo. Nerve growth factor is involved in maintaining and organizing cholinergic neurons in the central nervous system. These findings suggest that H. erinaceus may be appropriate for the prevention or treatment of dementia. In the present study, we examined the effects of H. erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Mice were administered 10 μg of amyloid β(25-35) peptide intracerebroventricularly on days 7 and 14, and fed a diet containing H. erinaceus over a 23-d experimental period. Memory and learning function was examined using behavioral pharmacological methods including the Y-maze test and the novelobject recognition test. The results revealed that H. erinaceus prevented impairments of spatial short-term and visual recognition memory induced by amyloid β(25-35) peptide. This finding indicates that H. erinaceus may be useful in the prevention of cognitive dysfunction.

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confidence: 99%

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

et al. 2011

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“…A renewed interest in this class of natural products was initiated by the discovery that members of the erinacine and scabronines class stimulate the biosynthesis of nerve growth factor (NGF). [9][10][11][12][13]17,[20][21][22][23][24] In a bioassay using mouse astroglial cells in the presence of erinacines A, B, and C, the amounts of NGF detected in the culture medium were four fold, two fold, and five fold higher than in the presence of epinephrine, a known potent NGF stimulator used as a positive control-compound in the assay.…”

Section: Biological Activities Of the Cyathanesmentioning

confidence: 99%

Enantioselective Total Synthesis of Cyathin A₃

Ward

Shen

2007

Org. Lett.

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The cyathins are a unique group of diterpenoids produced by the bird's nest fungi Cyathus helenae, C. africanus, and C. earlei In Section 2.2, the enantioselective Diels-Alder reaction of quinone 106 and diene 105 is presented. This reaction is effectively catalyzed by a carefully iii prepared Mikami catalyst. It was carried out on a preparative scale to give the chiral building block 108. The absolute configuration of the Diels-Alder adduct 108 was determined by NMR and X-ray analysis.

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“…Several of them, i.e. erinacines A-H, are known to have a potent stimulating effect on Nerve Growth Factor (NGF) synthesis in vitro [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Solid State Cultivation of Hericium erinaceus Biomass and Erinacine: A Production

Gerbec

Gregori²,

Kreft³

et al. 2015

J Bioprocess Biotech

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Hericium erinaceus is a medicinal mushroom producing biologically active metabolite erinacin A. In this research we compared fungal growth and metabolite production in different reactor types and different substrates with added casein peptone and NaCl. Cultivation of fungal biomass was performed in glass jars and horizontal stirred tank reactor. The cultivation in reactor was carried out at 24°C and airflow 5 L/min. Periodical mixing of N = 80 rpm, was used. Solid state substrate based on mixture of husked millet and paddy millet was used. For simultaneous determination of erinacine A and ergosterol contents in a single sample new analytical method was developed. The amount of biomass obtained in glass jars averaged at 100 mg/g ± 12 mg/g, while in horizontal mixing bioreactor it easily raised up to 350 mg/g. The highest erinacin A concentration was detected in substrate with 0.56% NaCl and 3.4% casein peptone content.

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Two Novel Diterpenoids, Erinacines H and I from the Mycelia of Hericium erinaceum

Abstract: Novel diterpenoids, erinacines H (1) and I (3), were isolated from the cultured mycelia of Hericium erinaceum. The structures of the compounds were determined by interpretation of the spectral data. Erinacine H showed stimulating activity of nerve growth factor (NGF)-synthesis.

Cited by 150 publications

References 4 publications

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

Enantioselective Total Synthesis of Cyathin A₃

Solid State Cultivation of Hericium erinaceus Biomass and Erinacine: A Production

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Two Novel Diterpenoids, Erinacines H and I from the Mycelia of Hericium erinaceum

Abstract: Novel diterpenoids, erinacines H (1) and I (3), were isolated from the cultured mycelia of Hericium erinaceum. The structures of the compounds were determined by interpretation of the spectral data. Erinacine H showed stimulating activity of nerve growth factor (NGF)-synthesis.

Cited by 150 publications

References 4 publications

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

Enantioselective Total Synthesis of Cyathin A3

Solid State Cultivation of Hericium erinaceus Biomass and Erinacine: A Production

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Enantioselective Total Synthesis of Cyathin A₃