“…During the last few decades, variation in the mitochondrial DNA (mtDNA) molecule has been studied in the context of many complex multifactorial diseases [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] . In this regard, the search for mtDNA variation related to infertility has also received the attention of a vast body of literature [10] , [11] , [12] , [13] , [14] , [15] , [16] , [36] . Some of the positive findings were critically questioned by others [13] , [17] , who pointed out problems of different nature, including methodological and theoretical misconceptions, as well as important statistical deficiencies [7] , [18] , [19] , [20] , [21] .…”