Two Novel Phenolic Compounds from the Rhizomes of Cyperus rotundus L.

Zhou, Zhongliu; Yin, Wei

doi:10.3390/molecules171112636

Cited by 32 publications

(20 citation statements)

References 11 publications

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“…Our finding was in agreement with the reported antioxidant (Yazdanparast and Ardestani, 2007) and hepatoprotective efficacy of C. Rotundus total extract in CCl 4 -induced hepatic injury in rats (Gilani and Janbaz, 1995, Mohamed, 2015). The observed hepatoprotective effect of C. rotundus against DCFH-cytotoxicity can be attributed to the presence of flavonoids and related phenolic compounds which are well known as antioxidants and free radical scavengers (Sunil et al, 2011, Zhou and Yin, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…C. rotundus extracts are reported to have several biological activities like, anti-inflammatory (Tandon et al, 2010), in vivo hepatoprotective (Gilani and Janbaz, 1995), antimalarial (Thebtaranonth et al, 1995, Rukunga et al, 2008), antidiarrhoeal (Uddin et al, 2006), antioxidant (Yazdanparast and Ardestani, 2007) antimicrobial (Chen et al, 2011), antiplatelet (Seo et al, 2011), neuroprotective (Kumar et al, 2013), anti-hyperglycemic and anti-nociceptive (Alam et al, 2011, Chaulya et al, 2011). Previous phytochemical screening of C. rotundus showed that it contains many phytoconstituents including flavonoids (Sunil et al, 2011), alkaloids (Sayed et al, 2008) and polyphenols (Zhou and Yin, 2012, Dhillon et al, 1993). Moreover, eight sesquiterpenes, nootkatone, valencene epi-guaidiol, sugebiol, guaidiolA, sugetriol triacetate, cyperenoic acid and cyperotundone were isolated from its rhizomes (Thebtaranonth et al, 1995, Dhillon et al, 1993, Jin et al, 2011, Xu et al, 2009, Tsoyi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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The in vitro and in vivo anti-hepatotoxic, anti-hepatitis B virus and hepatic CYP450 modulating potential of Cyperus rotundus

Parvez

Al‐Dosari

Arbab

et al. 2019

Saudi Pharmaceutical Journal

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In the present study we investigated the hepatotoprotective, hepatitis B virus (HBV) inhibitory and hepatic CYP450 enzyme (CYP3A4) modulatory potential of Cyperus rotundus rhizome fractions. The crude ethanol-extract, including different organic and aqueous fractions were tested for in vitro cytoprotection on HepG2 cells (MTT assay), followed by in vivo evaluation in Wistar rats (serum biochemistry and lipid profile). The in vitro anti-HBV activity was tested on HepG2.2.15 cells (HBsAg and HBeAg Elisa). Of these, the n-butanol and aqueous fractions showed the most promising, dose-dependent hepatoprotection in DCFH-injured HepG2 cells. Further, in CCl 4 -injured rats, oral administration of C. rotundus (100 and 200 mg/kg·bw/day) significantly normalized serum markers of healthy liver function (SGOT, SGPT, GGT, ALP and bilirubin) and lipid profile (cholesterol, HDL, LDL, VLDL, TG and MDA), including tissue NP-SH and TP levels. Compared to other fractions, the ethyl acetate, n-butanol and aqueous fractions exhibited the best inhibitory effects on viral HBsAg and HBeAg secretions in dose- and time-dependent manner. In addition, reporter gene assay (Dual-luciferase) of transfected HepG2 cells showed mild activation of nuclear PXR-mediated CYP3A4 gene by the three active fractions. Taken together, C. rotundus showed very promising hepatoprotective and anti-HBV potential in experimental settings . In addition, this is the first report on modulation of CYP3A4 by C. rotundus that suggests its safe consumption in relation to drug metabolism and efficacy. Our data could therefore, provide the basis for the ethnobotanical medicinal use of C. rotundus in metabolic liver disorder and hepatitis B patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The in vitro and in vivo anti-hepatotoxic, anti-hepatitis B virus and hepatic CYP450 modulating potential of Cyperus rotundus

Parvez

Al‐Dosari

Arbab

et al. 2019

Saudi Pharmaceutical Journal

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“…The distinct smell of teki is originated from the essential oil which is a volatile component giving the peculiar smell of teki (Mohamed, 2015). Such compound are for example cineole, cyperene, cyperenone, cyperol, cyprerotundone, limonene (Zhou and Yin, 2012). This research used the other materials which are strawberry, pineapple, and soursop that can fix the taste and smell.…”

Section: The Organoleptic Test Of the Functional Beverage Of The Extrmentioning

confidence: 99%

Functional Drinks from a Rhizome of Nut Grass (Cyperus rotundus L.) with Mixed Fruits

Devi¹,

Soekopitojo²,

Merawati³

2020

Proceedings of the 2nd International Conference on Social, Applied Science, and Technology in Home Economics (ICONHOMECS 2019)

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This research aims to get the technology of production process of the functional beverage of teki extract to obtain the formula of the functional beverage made of teki grass rhizome extract preferred by girls teenagers to cure the dysmenorrhoea problem. Such functional beverage is made of the extract of teki grass rhizome and the extract of any fruits such as pineapple, strawberry, and soursop added sugar and water. The production of teki extract is through the stages of sorting, washing, blanching, demolition, blending, heating and filtering. The chemical quality (Ca, Mg and Femineral) and the organoleptic characteristics (hedonic and hedonic quality) of teki extract were analyzed, and the experimentalmouse was pre-clinical tested to know its effect on the heart function by using SGPT and SGOT analysis. The research results show that the formula of teki extract with the rhizome of teki grass and the extract of pineapple (b/b) is recommended based on the hedonic characteristics andhedonic quality of taste, smell and the mineral contain such as Ca (2.27 ppm), Mg (46,94 ppm) and Fe (1,09 ppm).The teki extract has sweet-sour taste and theratherstrongdistinctive smell of teki.

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“…[ 58 ] The rhizomes are also the source of two new phenolics, 1alpha-methoxy -3beta - hydroxy-4alpha (3′,4′-dihydroxyphenyl)-1,2,3,4-tetrahydronaphthalene and its demethylated parent. [ 59 ]…”

Section: Phytochemistrymentioning

confidence: 99%

Abhava pratinidhi dravya: A comparative phytochemistry of Ativisha, Musta and related species

Muthialu

Kuruvilla

Kumar

et al. 2015

J Ayurveda Integr Med

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Authentic Ativisha (Aconitum heterophyllum) is a rare, endangered Himalayan species. Ayurveda classical texts of c. 15th–16th century, introduced “abhava-pratinidhi dravya” concept, wherein Ativisha was categorized as an abhava dravya (unavailable drug) and Musta (Cyperus rotundus) was suggested as a pratinidhi dravya (substitute) for it. C. rotundus is a weed, abundantly available pan-India. Cryptocoryne spiralis (Naattu Athividayam) and Cyperus scariosus (Nagarmotha) are also traded as Ativisha and Musta, respectively. Yet, there are no scientific studies to validate the use of substitutes. A. heterophyllum bears no similarity in terms of botanical classification with the other candidates. This article reviews published literature with an emphasis to look for similar phytochemicals or groups of phytochemicals in the species that could contribute to similar pharmacological activities, thereby supporting the drug substitution from a bio-medical perspective. Alkaloids like atisine were found to be the main focus of studies on A. heterophyllum, whereas for the Cyperus spp., it was terpenoids like cyperene. Although alkaloids and terpenoids were reported from both species, alkaloids in C. rotundus and terpenoids in A. heterophyllum were minor constituents. Reports on phytochemicals on Cryptocoryne spiralis and C. scariosus were very limited. Despite no significant similarities in chemical profiles reported, the dravyaguna (Ayurvedic drug classification) of Ativisha and Musta was quite similar warranting further exploration into the bio-functional aspects of the drug materials.

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Two Novel Phenolic Compounds from the Rhizomes of Cyperus rotundus L.

Cited by 32 publications

References 11 publications

The in vitro and in vivo anti-hepatotoxic, anti-hepatitis B virus and hepatic CYP450 modulating potential of Cyperus rotundus

The in vitro and in vivo anti-hepatotoxic, anti-hepatitis B virus and hepatic CYP450 modulating potential of Cyperus rotundus

Functional Drinks from a Rhizome of Nut Grass (Cyperus rotundus L.) with Mixed Fruits

Abhava pratinidhi dravya: A comparative phytochemistry of Ativisha, Musta and related species

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