Two-photon active nucleus-targeting carbon dots: enhanced ROS generation and photodynamic therapy for oral cancer

Nasrin, Aklima; Hassan, Mahbub; Gomes, Vincent G.

doi:10.1039/d0nr05210h

Cited by 85 publications

(54 citation statements)

References 23 publications

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“…Several papers have reported that targeting using folic acid receptors does not seem to have a significant effect on increasing phototoxicity [47]. However, many studies have reported that active targeting using folic acid ligands increases phototoxicity [48][49][50]. In this study, FA-conjugated FA-PEAH-UCNPs-Pha showed higher phototoxicity than free Pha and CH3-PEAH-UCNPs-Pha, possibly due to improved cellular uptake by the FA receptor-medicated endocytosis process.…”

Section: In Vitro Phototoxicity Of Ucnp-based Nanocarriersmentioning

confidence: 58%

NIR Photoregulated Theranostic System Based on Hexagonal-Phase Upconverting Nanoparticles for Tumor-Targeted Photodynamic Therapy and Fluorescence Imaging

Zhao

Choi

et al. 2020

Nanomaterials

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Although photodynamic therapy (PDT) is an effective, minimally invasive therapeutic modality with advantages in highly localized and specific tumor treatments, large and deep-seated cancers within the body cannot be successfully treated due to low transparency to visible light. To improve the therapeutic efficiency of tumor treatment in deep tissue and reduce the side effects in normal tissue, this study developed a near-infrared (NIR)-triggered upconversion nanoparticle (UCNP)-based photosensitizer (PS) carrier as a new theranostics system. The NaYF4:Yb/Er UCNPs were synthesized by a hydrothermal method, producing nanoparticles of a uniformly small size (≈20 nm) and crystalline morphology of the hexagonal phase. These UCNPs were modified with folic acid-conjugated biocompatible block copolymers through a bidentate dihydrolipoic acid linker. The polymer modified hexagonal phase UCNPs (FA-PEAH-UCNPs) showed an improved dispersibility in the aqueous solution and strong NIR-to-vis upconversion fluorescence. The hydrophobic PS, pheophorbide a (Pha), was then conjugated to the stable vectors. Moreover, these UCNP-based Pha carriers containing tumor targeting folic acid ligands exhibited the significantly enhanced cellular uptake efficiency as well as PDT treatment efficiency. These results suggested that this system could extend the excitation wavelength of PDT to the NIR region and effectively improve therapeutic efficiency of PSs.

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Section: In Vitro Phototoxicity Of Ucnp-based Nanocarriersmentioning

confidence: 58%

NIR Photoregulated Theranostic System Based on Hexagonal-Phase Upconverting Nanoparticles for Tumor-Targeted Photodynamic Therapy and Fluorescence Imaging

Zhao

Choi

et al. 2020

Nanomaterials

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“…Biomaterial-mediated photodynamic therapy. PDT 18,56 relies on photosensitizers to generate ROS under irradiation with external light at a specific wavelength to kill tumours. Since maxillofacial tumours usually occur in areas with easy access to light irradiation, PDT can be conveniently implemented.…”

Section: Biomaterial-mediated Chemotherapymentioning

confidence: 99%

“…Moreover, two-photon active photosensitizers that release lethal ROS for nucleus-targeting PDT were also proven feasible in oral cancer therapy. Nasrin et al 56 fabricated novel conjugated carbon dots (CDs) combined with curcumin and folic acid to enhance internalization; accordingly, elevated cancer cell destruction was observed via a direct attack on DNA. In addition to carbon dots, iron oxide nanoparticles show potential for PDT; additionally, their imaging capacity is worth studying.…”

Section: Biomaterial-mediated Chemotherapymentioning

confidence: 99%

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

et al. 2021

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Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone defects. In traditional tumour therapy, the systemic toxicity of chemotherapeutic drugs, invasive surgical resection, intractable tumour recurrence, and metastasis are major threats to the patients’ lives in the clinic. Fortunately, biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis, suggesting new promising antitumour therapies. In addition, maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients, and investment in treatment can result in a multitude of burdens to society. Biomaterials are promising options because they have good biocompatibility and bioactive properties for stimulation of bone regeneration. More interestingly, an integrated material regimen that combines tumour therapy with bone repair is a promising treatment option. Herein, we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect repair. Furthermore, we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future.

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“…The ROS HO• can synergize the chemotherapy by a cascade of bioreactions ( Figure 9 ). In addition, PDT is a promising clinical cancer treatment strategy, and it is also a common means of increasing ROS content and enhancing ROS-induced anticancer strategy [ 88 , 89 , 90 , 91 , 92 ]. PDT converts O 2 into ROS by light-activated PSs, while CDT generates cytotoxic •OH by an in situ Fenton or Fenton-like reaction between H 2 O 2 and catalysts [ 93 , 94 ].…”

Section: Activated Cascade Reactions To Enhance Ros-induced Cancer Therapymentioning

confidence: 99%

Application of Nano-Drug Delivery System Based on Cascade Technology in Cancer Treatment

Sun

2021

IJMS

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In the current cancer treatment, various combination therapies have been widely used, such as photodynamic therapy (PDT) combined with chemokinetic therapy (CDT). However, due to the complexity of the tumor microenvironment (TME) and the limitations of treatment, the efficacy of current treatment options for some cancers is unsatisfactory. Nowadays, cascade technology has been used in cancer treatment and achieved good therapeutic effect. Cascade technology based on nanotechnology can trigger cascade reactions under specific tumor conditions to achieve precise positioning and controlled release, or amplify the efficacy of each drug to improve anticancer efficacy and reduce side effects. Compared with the traditional treatment, the application of cascade technology has achieved the controllability, specificity, and effectiveness of cancer treatment. This paper reviews the application of cascade technology in drug delivery, targeting, and release via nano-drug delivery systems in recent years, and introduces their application in reactive oxygen species (ROS)-induced cancer treatment. Finally, we briefly describe the current challenges and prospects of cascade technology in cancer treatment in the future.

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Two-photon active nucleus-targeting carbon dots: enhanced ROS generation and photodynamic therapy for oral cancer

Abstract: Novel conjugated carbon dots (CDs) were synthesized as two-photon active photosensitisers to unleash lethal reactive oxygen species (ROS) for nucleus targeting photodynamic therapy (PDT). To enhance therapeutic efficiency and preclude...

Cited by 85 publications

References 23 publications

NIR Photoregulated Theranostic System Based on Hexagonal-Phase Upconverting Nanoparticles for Tumor-Targeted Photodynamic Therapy and Fluorescence Imaging

NIR Photoregulated Theranostic System Based on Hexagonal-Phase Upconverting Nanoparticles for Tumor-Targeted Photodynamic Therapy and Fluorescence Imaging

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

Application of Nano-Drug Delivery System Based on Cascade Technology in Cancer Treatment

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