Two polymethoxylated flavonoids with antioxidant activities and a rearranged clerodane diterpenoid from the leaf exudates of Microglossa pyrifolia

Akimanya, Aggrey; Midiwo, Jacob O.; Matasyoh, Joseph; Okanga, Francis I.; Masila, Veronica M.; Walker, Larry; Tekwani, Babu L.; Muhammad, Ilias; Omosa, Leonidah Kerubo

doi:10.1016/j.phytol.2014.12.008

Cited by 14 publications

(12 citation statements)

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“…The methanol extract was reported to be cytotoxic and genotoxic against meristem cells of Allium cepa [ 49 ] Microglossa pyrifolia (Lam.) Kuntze Ovarian cysts [ 17 ], malaria [ 17 , 51 ] Antioxidant activity (leaf extracts) [ 52 ], cancer cell line cytotoxicity [ 53 ], antiplasmodial activity (dichloromethane leaf extract) [ 54 ] In vitro (2,2-diphenyl picryl hydrazyl (DPPH) assay) [ 52 ], In vitro (Resazurin assay) [ 53 ], In vitro (lactate dehydrogenase assay) [ 54 ] The organic leaf extract was reported to be cytotoxic against CCRF-CEM leukemia and decreased cell growth by 48% [ 53 ] Tithonia diversifolia (Hemsl.) A.…”

Section: Resultsmentioning

confidence: 99%

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Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

et al. 2020

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Background: Poor access to healthcare in rural communities causes many people to seek herbalists who use medicinal plants for the treatment of various disease conditions. Most knowledge of traditional herbal medicine makes use of indigenous remedies which are often undocumented and are at risk of being lost. The preservation of this knowledge may facilitate scientific inquiry into promising new therapeutic molecules. Methods: Semi-structured questionnaires were used to collect the sociodemographic information of 30 herbalists in Kisumu East Sub County. The local names of medicinal plants used in managing illnesses of the respiratory system, their habit, active parts, indications, methods of preparation, routes of administration, scientific identity, and conservation status were also recorded. Other reported traditional uses, pharmacological activities, and toxicological data were identified via a literature search. Results: Most herbalists were female (86.7%), aged between 61 and 70 years (43.3%) with no formal education (56.7%), and had 21-30 years of practice (30%). 44 plant species, belonging to 43 genera and 28 families were identified. Leguminosae and Rutaceae plant families were predominant, leaves were frequently used (33%), and trees were the most common habit (44.4%). Most plants were collected in the wild (79.2%), preparation was mainly by decoction (68.8%), and the administration was mainly orally. The main indication was cough and 79.5% of all documented plant species had previously been reported to have a pharmacological activity relevant to the mitigation of respiratory illnesses. Toxicological data was available for 84.1% of the plant species identified. Conclusions: The predominant use of roots, root barks, and root tubers by herbalists in Kisumu East Sub County threatens to negatively impact the ecological survival of some plant species. The preservation of herbalists' knowledge of medicinal plants in the study area is a pressing concern considering their advanced age and little formal education. There is a need to conserve some of the medicinal plants documented in this study. The medicinal claims made by herbalists also warrant scientific scrutiny.

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Section: Resultsmentioning

confidence: 99%

“…Ovarian cysts [17], malaria [17,51] Antioxidant activity (leaf extracts) [52], cancer cell line cytotoxicity [53], antiplasmodial activity (dichloromethane leaf extract) [54] In vitro (2,2-diphenyl picryl hydrazyl (DPPH) assay) [52],…”

Section: Diversity Of Medicinal Plants Identified In the Study Area Amentioning

confidence: 99%

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

et al. 2020

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“…Table 3. [33], tuberculosis [34] Methanol and aqueous root extract showed antibacterial properties [35], the aqueous, methanol and ethanolic stem bark extracts showed diuretic activity but were also reported to cause damage to vital organs [36] Carissa edulis (Forssk.) Vahl Respiratory infections [16] Chest pains [37,38] Pet-ether and ethanolic extracts were active against Staphylococcus aureus and E. coli [39], the presence of alkaloids, sterols and resins was also reported [39] Artemisia annua L.…”

Section: Dosage Mode Of Preparation and Route Of Administrationmentioning

confidence: 99%

Medicinal Plants Used In Managing Diseases Of The Respiratory System Among The Luo Community: An Appraisal Of Kisumu East Sub-County, Kenya

Mailu

Nguta

Mbaria

et al. 2020

Preprint

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Background Respiratory diseases cause many deaths in children under 5 years of age particularly in Africa. The efficacy of current treatment differs among respiratory diseases and adverse effects may depend on dosage, duration of treatment, and the type of drug. Poor access to healthcare in rural areas makes many people in such communities to rely on traditional medicine. Most knowledge on traditional medicine makes use of indigenous remedies which are often undocumented and are at risk of being lost. Ethnobotanical data on medicinal plants used in managing diseases of the respiratory system may facilitate the search for new pharmaceutical agents. Methods Semi-structured questionnaires were used to collect information from 30 traditional medicine practitioners in Kisumu East Sub County. The sociodemographic characteristics of the informants, the local names of the plants used, their habit, active parts, indications, and methods of preparation, as well as routes of administration, scientific identity, and conservation status were recorded. A literature search was conducted via PubMed, Google Scholar, and Research Gate to identify other reported activities of the plants. Results Most practitioners were female (86.7%), were aged between 61 and 70 years (43.3%), had no formal education (56.7%), and had 21-30 years of practice (30%). A total of 45 plant species, belonging to 43 genera and 28 families were identified. Leguminosae and Rutaceae were the most dominant plant families, leaves were the most frequently used (33%), and trees were the most common habit (44.4%). Cough was the most common indication, decoction was the most common method of administration (68.8%), most preparations were taken orally, and most plants were collected in the wild (79.2%). Literature search established that at least 42/45 plant species had pharmacological activities. Conclusions Many plant species reported in this study have similar traditional uses in other communities. One plant; Keetia gueinzii (Sond.) Bridson was reported for the first time in the management of asthma, pneumonia, and cough. Documentation and preservation of ethno medicinal knowledge in the study area is of prime concern as most practitioners are advanced in age with little formal education. Plans to conserve some of the medicinal plants documented here should be initiated. Scientific validation of the traditional claims made is also needed.

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“…It was reported that flavonoids possess antioxidant activity especially luteolin derivatives and methoxylated flavonoids. 24 The DPPH reaction mechanism with the compounds that exhibited activity depending upon the free OH groups in B-ring, so the flavons exhibited more activity that the flavons 7-O-glycosides. 25 Anti-inflammatory activity…”

Section: Antioxidant Activitymentioning

confidence: 99%

Phenolic Constituents, Anti-Inflammatory and Antidiabetic Activities of Cyperus laevigatus L.

Elshamy¹,

El-Shazly²,

Yassine³

et al. 2017

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Background: Cyperus species are well known traditional plants and used for several diseases around the world. Aim of the Study: Our study aimed to identification of the phenolic constituents in addition to evaluation of different extracts of Cyperus laevigatus L as antioxidant, antiinflammatory and antidiabetic agents. Materials and Methods: The phenolic constituents were identified using spectroscopic techniques. The antioxidant activity was evaluated using in vitro DPPH assay. Total extract, methanol and EtOAc fractions were evaluated for their antiinflammatory activity using RAW 264.7 macrophages assay. Antidiabetic activity of the total extract was examined biochemically and histopathologically using streptozotocin-induced diabetic rats. Results: A new flavone, chrysoeriol 7-O-β-(6‴-O-acetyl-β-D-glucopyranosyl)-(1→4) glucopyranoside (1), along with seven knowns (2-8) were isolated from Cyperus laevigatus L. The structures of isolated compounds were established depending upon 1D, 2D-NMR and HR-ESI-MS. The MeOH and EtOAc fractions exhibited significant antioxidant activity while the isolated flavonoids exhibited from moderate to weak antioxidant activity. The total extract, MeOH and EtOAc fractions exhibited significant anti-inflammatory activity using LPS-stimulated RAW 264.7 macrophages model by decreasing of NO accumulation by 76-66% and 84-67%, of the original accumulation values with increasing concentrations in comparison with the reference drug, dexamethasone. The total extract exhibited antidiabetic activity in streptozotocin-induced diabetic rats and this effect was manifested by decreasing serum levels of glucose, glucagon and NO. It also increased level of insulin and promoted paraoxonase activity. Conclusion: These results proved that this plant may be multiple sources for medicinal natural drugs especially for anti-inflammatory and antidiabetic.

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Two polymethoxylated flavonoids with antioxidant activities and a rearranged clerodane diterpenoid from the leaf exudates of Microglossa pyrifolia

Cited by 14 publications

References 19 publications

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

Medicinal Plants Used In Managing Diseases Of The Respiratory System Among The Luo Community: An Appraisal Of Kisumu East Sub-County, Kenya

Phenolic Constituents, Anti-Inflammatory and Antidiabetic Activities of Cyperus laevigatus L.

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