Two possible ways to combine boron and gadolinium for Gd-guided BNCT. A concept

Anufriev, Sergey A.; Sivaev, Igor B.; Nakamura, Hiroyuki

doi:10.1080/10426507.2020.1804151

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…To the best of our knowledge, there is only one communication in the literature on the synthesis of the gadolinium dicarbollide complex [3,3-(THF) 2 -3,3′-Gd(1,2-C 2 B 9 H 11 ) 2 ] − [ 30 ], however, its characterization is not sufficient to be reliable. At the same time, a careful analysis of the literature on dicarbollide complexes of other lanthanides showed that complexes of this type are usually unstable due to loss of solvent molecules, however their stability can be increased by using carborane ligands with substituents containing pendant donor groups [ 31 ]. In this case, the donor groups take the place of easily removable molecules of the coordinated solvent, which leads to an increase in the complex stability due to the chelate effect.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Bis(Carboranyl)amides 1,1′-μ-(CH2NH(O)C(CH2)n-1,2-C2B10H11)2 (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide)

et al. 2021

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Bis(carboranyl)amides 1,1′-μ-(CH2NH(O)C(CH2)n-1,2-C2B10H11)2 (n = 0, 1) were prepared by the reactions of the corresponding carboranyl acyl chlorides with ethylenediamine. Crystal molecular structure of 1,1′-μ-(CH2NH(O)C-1,2-C2B10H11)2 was determined by single crystal X-ray diffraction. Treatment of bis(carboranyl)amides 1,1′-μ-(CH2NH(O)C(CH2)n-1,2-C2B10H11)2 with ammonium or cesium fluoride results in partial deboronation of the ortho-carborane cages to the nido-carborane ones with formation of [7,7′(8′)-μ-(CH2NH(O)C(CH2)n-7,8-C2B9H11)2]2−. The attempted reaction of [7,7′(8′)-μ-(CH2NH(O)CCH2-7,8-C2B9H11)2]2− with GdCl3 in 1,2-dimethoxy- ethane did not give the expected metallacarborane. The stability of different conformations of Gd-containing metallacarboranes has been estimated by quantum-chemical calculations using [3,3-μ-DME-3,3′-Gd(1,2-C2B9H11)2]− as a model. It was found that in the most stable conformation the CH groups of the dicarbollide ligands are in anti,anti-orientation with respect to the DME ligand, while any rotation of the dicarbollide ligand reduces the stability of the system. This makes it possible to rationalize the design of carborane ligands for the synthesis of gadolinium metallacarboranes on their base.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Bis(Carboranyl)amides 1,1′-μ-(CH2NH(O)C(CH2)n-1,2-C2B10H11)2 (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide)

et al. 2021

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“…The researchers incorporated Gd-DTPA complexes on the silica layer surfaces of this nanoparticle, so that it could also well-behave in the MR imaging and exploit the therapeutic effects of GdBNCT at the same time 92 . One other related study showed several means of combination of 10 B and 157 Gd which can be used in Gd-guided BNCT, which pointed out that there are mainly two synthesis modes of this dual element agent, one was based on DOTA chelators and the other one was based on the structure of carborane cages 93 . Different approaches to chemical synthesis could figure out the stability and toxicity of various types of these compounds.…”

Section: B-gd Binary Nanomedicinementioning

confidence: 99%

Recent progress of nano-drugs in neutron capture therapy

Zhou,

Cheng,

Liu

et al. 2024

Theranostics

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As a developing radiation treatment for tumors, neutron capture therapy (NCT) has less side effects and a higher efficacy than conventional radiation therapy. Drugs with specific isotopes are indispensable counterparts of NCT, as they are the indespensable part of the neutron capture reaction. Since the creation of the first and second generations of boron-containing reagents, NCT has significantly advanced. Notwithstanding, the extant NCT medications, predominantly comprised of small molecule boron medicines, have encountered challenges such monofunctionality, inadequate targeting of tumors, and hypermetabolism. There is an urgent need to promote the research and development of new types of NCT drugs. Bio-nanomaterials can be introduced into the realm of NCT, and nanotechnology can give conventional medications richer functionality and significant adaptability. This can complement the advantages of each other and is expected to develop more new drugs with less toxicity, low side effects, better tumor targeting, and high biocompatibility. In this review, we summarized the research progress of nano-drugs in NCT based on the different types and sources of isotopes used, and introduced the attempts and efforts made by relevant researchers in combining nanomaterials with NCT, hoping to provide pivotal references for promoting the development of the field of tumor radiotherapy.

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“…Anufriev等人 [51] 提出了设计Gd-B双携带剂的两个方案: 一是修饰多胺多羧酸类配体, 一端螯合钆, 一端连接含硼基团, 并增加与各种生物大分子结合的官能团; 二是在碳硼烷上连接可与钆螯合的基团. Matsu-mura等人 [52] 最早开展了Gd-B双携带剂的研究.…”

Section: Gd-b双携带剂unclassified