Two potentially distinct pathways to geographic atrophy in age-related macular degeneration characterized by quantitative fundus autofluorescence

Wei, Wei; Mazzola, Marco; Otero-Marquez, Oscar; Tong, Yuehong; Souied, Eric H.; Querques, Giuseppe; Freund, K. Bailey; Rjh, Smith

doi:10.1038/s41433-022-02332-8

Cited by 10 publications

(8 citation statements)

References 35 publications

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“…In addition, several studies have supported the utility of AI to detect the presence of advanced exudative and nonexudative AMD with the use of OCT imaging 117–120 . Finally, AI and machine learning have been shown to utilize FAF in the detection of GA and to differentiate GA patterns 46 . With further developments, AI and machine learning may complement physicians’ abilities to treat patients.…”

Section: Discussionmentioning

confidence: 99%

“…[117][118][119][120] Finally, AI and machine learning have been shown to utilize FAF in the detection of GA and to differentiate GA patterns. 46 With further developments, AI and machine learning may complement physicians' abilities to treat patients.…”

Section: ' Discussionmentioning

confidence: 99%

“…43,44 Drusen volume does not correspond to increased qAF levels in early and intermediate AMD. 44,45 In more advanced GA, qAF levels can be helpful in differentiating 2 different processes of GA, such that the qAF level of eyes with soft drusen/pigment epithelial detachment-associated GA were lower than the qAF level in eyes with basal laminar deficit-associated GA. 46…”

Section: Color Fundus Photographymentioning

confidence: 99%

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Imaging Modalities for Dry Macular Degeneration

Samanta,

Alsoudi,

Rahimy

et al. 2023

International Ophthalmology Clinics

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Section: Discussionmentioning

confidence: 99%

Section: ' Discussionmentioning

confidence: 99%

Section: Color Fundus Photographymentioning

confidence: 99%

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Imaging Modalities for Dry Macular Degeneration

Samanta,

Alsoudi,

Rahimy

et al. 2023

International Ophthalmology Clinics

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“…Conversely, causes external to the neovascularization itself included drusen and subretinal drusenoid deposits (SDDs), as previously demonstrated. 24 Some eyes exhibited ROIs in multiple categories. The whole grading process was conducted independently by the two graders (C.B.…”

Section: Methodsmentioning

confidence: 99%

Distinct Pathways of Macular Atrophy in Type 3 Macular Neovascularization Associated With AMD

Borrelli,

Barresi,

Ricardi

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Purpose To explore the occurrence of macular atrophy (MA) in eyes with age-related macular degeneration (AMD)-associated Type 3 macular neovascularization (MNV) treated with anti-vascular endothelial growth factor (anti-VEGF) therapy. Importantly, we aimed at describing the existence of separate pathways leading to MA. Methods We analyzed 41 participants (41 eyes) with treatment-naïve Type 3 MNV who were followed up for a duration of 12 months after beginning the anti-VEGF therapy. At the one-year follow-up visit, optical coherence tomography (OCT) scans were reviewed for the presence of MA. MA regions of interest (ROIs) were selected and traced back to their original dominant baseline lesion (i.e., precursor) through previous serially captured OCT scans. Baseline lesions included precursors associated with the development and exudation of MNV and causes external to the neovascularization itself. Results At the one-year follow-up visit, MA was graded to be present in 38 (92.7%) out of 41 eyes. These 78 MA ROIs were divided into two subgroups according to the precursor lesion, yielding a group of 53 MA lesions with precursors associated with the development and exudation of MNV (i.e., MA caused by physical harm from Type 3 neovessels, collapse of a serous pigment epithelium detachment, and fibrosis) and 25 MA regions with precursors external to the neovascularization itself (i.e., MA caused by drusen or subretinal drusenoid deposits). Conclusions Eyes with Type 3 MNV are commonly complicated by MA and precursors of MA include causes associated with the development and exudation of MNV, as well as lesions unrelated to the neovascularization process itself.

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“…Quantitative autofluorescence has been found to be higher in GA lesions of patients with RPD/SDDs than in GA lesions of patients with soft drusen/PED and is thought to be due to basal laminar deposits in patients with RPD/SDDs. This finding suggests a potentially different pathway to GA [28]. A rare and aggressive variant of atrophic AMD referred to as extensive macular atrophy with pseudodrusen (EMAP) has been described as early-onset (<60 years), bilateral, and severe macular atrophy associated with numerous deposits resembling reticular pseudodrusen which extend towards the midperiphery and are accompanied by peripheral pavingstone degeneration [25,29].…”

Section: Early Detection Of Geographic Atrophymentioning

confidence: 99%

Identifying geographic atrophy

Clevenger

Rachitskaya

2023

Current Opinion in Ophthalmology

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Purpose of reviewAge-related macular degeneration (AMD) is one of the leading causes of blindness and can progress to geographic atrophy (GA) in late stages of disease. This review article highlights recent literature which assists in the accurate and timely identification of GA, and monitoring of GA progression. Recent findingsTechnology for diagnosing and monitoring GA has made significant advances in recent years, particularly regarding the use of optical coherence tomography (OCT). Identification of imaging features which may herald the development of GA or its progression is critical. Deep learning applications for OCT in AMD have shown promising growth over the past several years, but more prospective studies are needed to demonstrate generalizability and clinical utility.

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Two potentially distinct pathways to geographic atrophy in age-related macular degeneration characterized by quantitative fundus autofluorescence

Cited by 10 publications

References 35 publications

Imaging Modalities for Dry Macular Degeneration

Imaging Modalities for Dry Macular Degeneration

Distinct Pathways of Macular Atrophy in Type 3 Macular Neovascularization Associated With AMD

Identifying geographic atrophy

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