Two roads diverged: Emerging lessons from <scp>IVIG</scp> about hemolysis

Asif, Maryam; Khor, Bernard

doi:10.1111/trf.16326

Cited by 1 publication

(2 citation statements)

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“… 25 Acute haemolysis has been reported during IVIg treatment; 26 , 27 and the patients had serum antibodies against blood-group antigens; and some patients, mainly those with a non-O blood group, had haemolytic reactions during IVIg infusion. 24 The current patient’s blood was type A, consistent with these findings.…”

Section: Discussionsupporting

confidence: 83%

“… 23 IVIg is a blood product and its main component is protein, more than 95% of which is Ig, including IgG antibodies against a broad spectrum of viruses, bacteria and other pathogens. 24 Since plasma products can contain blood-group antibodies (e.g. anti-A, anti-B, anti-D), they can act as a haemolysin and induce red blood cell aggregation in the recipient, resulting in a positive direct antiglobulin test and haemolysis.…”

Section: Discussionmentioning

confidence: 99%

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Hepatitis B virus-associated cryoglobulinaemia diffuse endocapillary proliferative glomerulonephritis: a case report and literature review

Han

2022

J Int Med Res

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Cryoglobulinaemia can manifest as fatigue, purpura, and joint pain, and can involve the kidneys and peripheral nervous system. Type II and mixed cryoglobulinemia cases are usually associated with hepatitis C virus infection and autoimmune diseases, and most cases reported outside China have been related to hepatitis C virus. The pathological manifestation of cryoglobulinaemia glomerulonephritis is always membranous proliferative glomerulonephritis or membranous nephropathy; other pathological types are rare. This current case report describes a female patient with hepatitis B virus (HBV)-associated cryoglobulinaemic glomerulonephritis. The patient had hepatitis B complicated with purpura, abnormal urinalysis and renal function. She was positive for rheumatoid factor and had decreased complement, and her blood cryoglobulin level was positive. The pathological findings were consistent with late-stage capillary proliferative glomerulonephritis, which improved after steroid, immunosuppressant and anti-HBV treatment.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%