Two-stage ZnS Shell Coating on the CuInS2 Quantum Dots for Their Effective Solubilization

Vokhmintcev, Kirill V.; Linkov, Pavel; Samokhvalov, Pavel; Nabiev, Igor

doi:10.18502/ken.v3i2.1862

Cited by 4 publications

(9 citation statements)

References 1 publication

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“…The second ZnS shell layer was applied using the procedure from [ 35 ]. The zinc and sulfur precursors for second shell growth were prepared according to the following procedure.…”

Section: Methodsmentioning

confidence: 99%

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Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes

et al. 2020

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Nowadays, multiplex analysis is very popular, since it allows to detect a large number of biomarkers simultaneously. Traditional multiplex analysis is usually based on changes of photoluminescence (PL) intensity and/or PL band spectral positions in the presence of analytes. Using PL lifetime as an additional parameter might increase the efficiency of multiplex methods. Quantum dots (QDs) can be used as luminescent markers for multiplex analysis. Ternary in-based QDs are a great alternative to the traditional Cd-based one. Ternary QDs possess all advantages of traditional QDs, including tunable photoluminescence in visible range. At the same time ternary QDs do not have Cd-toxicity, and moreover they possess long spectral dependent lifetimes. This allows the use of ternary QDs as a donor for time-resolved multiplex sensing based on Förster resonance energy transfer (FRET). In the present work, we implemented FRET from AgInS2/ZnS ternary QDs to cyanine dyes absorbing in different spectral regions of QD luminescence with different lifetimes. As the result, FRET-induced luminescence of dyes differed not only in wavelengths but also in lifetimes of luminescence, which can be used for time-resolved multiplex analysis in biology and medicine.

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“…The second ZnS shell layer was applied using the procedure from [ 35 ]. The zinc and sulfur precursors for second shell growth were prepared according to the following procedure.…”

Section: Methodsmentioning

confidence: 99%

“…The QDs were solubilized by the procedure described in [ 35 ]. A portion of the QD solution was purified twice using methyl acetate and hexane as the precipitant and the solvent, respectively.…”

Section: Methodsmentioning

confidence: 99%

Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes

et al. 2020

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“…The second (outer) ZnS shell layer was applied using the Zn and S precursors synthesized in advance [ 22 ]. Briefly, the zinc precursor was prepared by mixing 2-ethylhexanoic acid, zinc oxide, and ODE with subsequent heating until a clear solution was obtained.…”

Section: Methodsmentioning

confidence: 99%

“…The QDs were solubilized by the procedure described in [ 22 ]. Briefly, AIS/ZAIS/ZnS QDs were additionally washed twice with isopropanol and acetone with subsequent dissolution in chloroform to remove the excess of the original ligand.…”

Section: Methodsmentioning

confidence: 99%

“…Unlike classical binary Cd- and InP-based systems, ternary QDs are highly tolerant to off-stoichiometry and crystallographic defects both in the volume and on the surface of nanocrystals [ 8 , 9 , 10 , 11 , 12 , 13 ]. The composition and structure strongly affect ternary QD optical properties [ 14 , 15 , 16 , 17 , 18 ]; the latter may be, therefore, tuned in a broad range by changing the stoichiometry, doping, and alloying with the shell material during the synthesis or via post-synthetic treatments [ 3 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

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FRET-Based Analysis of AgInS2/ZnAgInS/ZnS Quantum Dot Recombination Dynamics

et al. 2020

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Ternary quantum dots (QDs) are very promising nanomaterials with a range of potential applications in photovoltaics, light-emitting devices, and biomedicine. Despite quite intensive studies of ternary QDs over the last years, the specific relaxation channels involved in their emission mechanisms are still poorly understood, particularly in the corresponding core-shell nanostructures. In the present work, we have studied the recombination pathways of AgInS2 QDs stabilized with the ZnAgInS alloy layer and the ZnS shell (AIS/ZAIS/ZnS QDs) using time-resolved fluorescence spectroscopy. We have also investigated FRET in complexes of AIS/ZAIS/ZnS QDs and cyanine dyes with the absorption bands overlapping in the different regions of the QD emission spectrum, which allowed us to selectively quench the radiative transitions of the QDs. Our studies have demonstrated that FRET from QDs to dyes results in decreasing of all QD PL decay components with the shortest lifetime decreasing the most and the longest one decreasing the least. This research presents important approaches for the investigation of ternary QD luminescence mechanisms by the selective quenching of recombination pathways. These studies are also essential for potential applications of ternary QDs in photodynamic therapy, multiplex analysis, and time-resolved FRET sensing.

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In Vivo Assessment of Acute Toxicity and Immunotoxicity of Quantum Dots with Different Physicochemical Properties

Gerasimovich,

Bozrova,

Baryshnikova

et al. 2023

Preprint

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Fluorescent semiconductor nanocrystals called quantum dots (QDs) have gained attention in biomedical applications, including imaging, molecular tracking, and drug delivery, due to their unique optical properties. However, their use is limited because of safety issues. This study was aimed at assessment the acute toxicity of QDs with different core chemical compositions and surface charges in mice. In addition, the immunotoxicity of CdSe/ZnS QDs was estimated. CdSe/ZnS, PbS/CdS/ZnS, and CuInS2/ZnS QDs were synthesized and modified with PEG derivatives. The hydrodynamic diameters and surface charges of solubilized QDs were characterized. The QD acute toxicity has been shown to depend on both surface charge and core composition. The immunotoxicity of CdSe/ZnS-PEG-OH QDs in mice was assessed after a single intravenous administration of 0.2 LD100 of the QDs. The QDs have been found to increase the spleen weight and cause spleen, thymus, and bone marrow cell depletion. However, these changes are reversible. A transient increase in the levels of proinflammatory cytokines (MCP1 and IL-6) indicates an acute inflammatory response to a single low dose of QDs. Thus, systemic comparative analysis of QD toxicity has shown how the QD core composition and surface properties affect living organisms.

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Two-stage ZnS Shell Coating on the CuInS2 Quantum Dots for Their Effective Solubilization

Cited by 4 publications

References 1 publication

Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes

Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes

FRET-Based Analysis of AgInS2/ZnAgInS/ZnS Quantum Dot Recombination Dynamics

In Vivo Assessment of Acute Toxicity and Immunotoxicity of Quantum Dots with Different Physicochemical Properties

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