Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

Abstract

Two-wk treatment with a proton pump inhibitor is as effective as four-week treatment for healing post ESD ulcers.

Vonoprazan is superior to proton pump inhibitors in healing artificial ulcers of the stomach post‐endoscopic submucosal dissection: A propensity score‐matching analysis

“…Previously, we reported the efficacy and safety of esomeprazole for post‐ESD ulcers of the stomach in a randomized controlled trial (RCT) (UMIN000006951) . Patients in the current study prospectively underwent gastric ESD, were given vonoprazan and, at 4 weeks after ESD, ulcer size was measured for our clinical trial (UMIN000018169).…”

Effects of esomeprazole on the healing process of post-endoscopic submucosal dissection gastric ulcers: a single arm, prospective trial

“…Arai et al . 18 ) reported that 2 weeks of PPI administration may be sufficient for ulcer healing. However, there is no consensus regarding the proper duration of PPI administration after ESD.…”

“…Arai et al . 18 ) compared the staging of post-ESD ulcers at week in patients receiving esomeprazole plus rebamipide for 2 weeks and 4 weeks, and found that the number of patients with ulcers in the healing/scar stage was 20/6 and 28/5, respectively. In these studies, patients received intravenous administration of 20 mg omeprazole for one or two days after the procedure.…”

Updated evidence on endoscopic resection of early gastric cancer from Japan

“…Arai et al [22] revealed that 2 weeks of PPI treatment had effects similar to those of 4 weeks of PPI treatment with regard to post-ESD ulcer healing. Takayama et al [23] revealed that 1 week of PPI treatment followed by 7 weeks of rebamipide treatment had effects similar to those of 8 weeks of PPI treatment with regard to post-ESD ulcer healing.…”

“…Five RCTs regarding post-ESD ulcer healing were identified [22][23][24][25][26]. Arai et al [22] revealed that 2 weeks of PPI treatment had effects similar to those of 4 weeks of PPI treatment with regard to post-ESD ulcer healing.…”