Type‐1 and Type‐2 Cytokines in Human Decidual Tissue and Trophoblasts from Normal and Abnormal Pregnancies Detected by Reverse Transcriptase Polymerase Chain Reaction (RT‐PCR)

Vives, Àngels; Balasch, Juan; Yagüe, Jordi; Quintó, Llorenç; Ordï, Jaume; Vanrell, Juan A.

doi:10.1111/j.1600-0897.1999.tb00113.x

Cited by 45 publications

(23 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, previous studies focusing on gestational tissues have reported either no significant differences [59,62,183] or a significant reduction in IL-10 expression in the presence of labor when compared to controls [184][185][186]. Of note, Hanna et al [59] reported a labor-associated up-regulation of TNF-a and IL-1 expression in placental explants and freshly isolated cytotrophoblasts in contrast to an absence of appreciable changes in IL-10 expression [59].…”

Section: Il-10 In Spontaneous Labor At Termmentioning

confidence: 78%

The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10

Gotsch

Romero

Kusanovic

et al. 2008

The Journal of Maternal-Fetal & Neonatal Medicine

122

View full text Add to dashboard Cite

Objective. The anti-inflammatory limb of the immune response is crucial for dampening inflammation. Spontaneous parturition at term and preterm labor (PTL) are mediated by inflammation in the cervix, membranes, and myometrium. This study focuses on the changes in the amniotic fluid concentrations of the anti-inflammatory cytokine interleukin (IL)-10. The objectives of this study were to determine whether there is a relationship between amniotic fluid concentrations of IL-10 and gestational age, parturition (at term and preterm), and intra-amniotic infection/inflammation (IAI). Study design. A cross-sectional study was conducted including 301 pregnant women in the following groups: (1) midtrimester of pregnancy who delivered at term (n ¼ 112); (2) mid-trimester who delivered preterm neonates (n ¼ 30); (3) term not in labor without IAI (n ¼ 40); (4) term in labor without IAI (n ¼ 24); (5) term in labor with IAI (n ¼ 20); (6) PTL without IAI who delivered at term (n ¼ 31); (7) PTL without IAI who delivered preterm (n ¼ 30); (8) PTL with IAI who delivered preterm (n ¼ 14). IL-10 concentrations in amniotic fluid were determined by a specific and sensitive immunoassay. Nonparametric statistics were used for analysis. Results.(1) IL-10 was detectable in amniotic fluid and its median concentration did not change with gestational age from mid-trimester to term. (2) Patients in labor at term had a significantly higher median amniotic fluid IL-10 concentration than that of patients at term not in labor (p ¼ 0.04). (3) Women at term in labor with IAI had a significantly higher median amniotic fluid IL-10 concentration than that of patients at term in labor without IAI (p ¼ 0.02). (4) Women with PTL and IAI who delivered preterm had a significantly higher median amniotic fluid concentration of IL-10 than those without IAI who delivered preterm and than those who delivered at term (p ¼ 0.009 and p 5 0.001, respectively). (5) Among patients with preterm labor without IAI, those who delivered preterm had a significantly higher median amniotic fluid IL-10 concentration than those who delivered at term (p ¼ 0.03). Conclusions. The anti-inflammatory cytokine IL-10 is detectable in the amniotic fluid of normal pregnant women. Spontaneous parturition at term and in preterm gestation is associated with increased amniotic fluid concentrations of IL-10. IAI (preterm and at term) is also associated with increased amniotic fluid concentrations of IL-10. We propose that IL-10 has a role in the regulation of the immune response in vivo by initiating actions that dampen inflammation.

show abstract

Section: Il-10 In Spontaneous Labor At Termmentioning

confidence: 78%

The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10

Gotsch

Romero

Kusanovic

et al. 2008

The Journal of Maternal-Fetal & Neonatal Medicine

122

View full text Add to dashboard Cite

show abstract

“…Besides Th cells, other sources of this cytokine could be natural killer, decidual, or endothelial cells. 22 The intracellular concentrations of IL-2 and IFN-y did not differ between preeclamptic and normotensive pregnant women. We observed a tendency toward lower cytokine expression among CD3+CD4+ and CD3+CD8+ cells from women with preeclampsia.…”

Section: Discussionmentioning

confidence: 98%

The Predominant Th1 Cytokine Profile in Maternal Plasma of Preeclamptic Women Is Not Reflected in the Choriodecidual and Fetal Compartments

Arriaga-Pizano¹,

Jiménez-Zamudio²,

Vadillo-Ortega³

et al. 2005

Journal of the Society for Gynecologic Investigation

View full text Add to dashboard Cite

show abstract

“…When the balance between ROS and protection mechanisms shifts toward prooxidant, excessive ROS will arise and damage will occur. Damage caused by free radicals (oxidative stress) and lipid peroxidation is involved in the pathophysiology of a various clinical circumstances [8]. Women who undergo abortions will have a significantly lower level of total thiol, ceruloplasmin, ascorbic acid, α-tocopherol, and erythrocyte glutathione than control group.…”

Section: Discussionmentioning

confidence: 99%

“…In the immunological pathway of Th1 there is an increase of embryotoxic IFN-γ, whereas in the immunological pathway of Th2 there is a decrease of IL-4 level. Vives et al [8] examined cytokine expression in the decidua and trophoblast tissue. The result showed a significantly increased level of IFN-γ in decidual tissue of women who undergo abortion.…”

Section: Discussionmentioning

confidence: 99%

The Role of Antioxidant Vitamin C on Imminent Abortion through Interaction of Superoxide Dismutase, Interferon-γ, Interleukin-4, Vascular Cells Adhesion Molecule-1, and Decidual Spiral Arteries Blood Flow

Handono¹,

Wirakusumah²,

Mose³

et al. 2015

OJOG

View full text Add to dashboard Cite

Imminent abortion needs more serious attention since it remains a big problem in Indonesia considering its epidemiology, morbidity, mortality, and prognosis. In fact, some cases can still be prevented. The objective of this study was to determine pathogenesis, diagnosis, and prognosis of imminent abortion through the role of antioxidant vitamin C in the interaction of superoxide dismutase (SOD), interferon-γ (IFN-γ), interleukin-4 (IL-4), vascular cells adhesion molecule-1 (VCAM-1), and decidual spiral artery resistance index (DSA RI). This study took 10 months from March to December 2007 at Obstetrics and Gynecology Department of Medical Faculty of Padjadjaran University/Hasan Sadikin Hospital, Bandung. Sixty pregnant women who met the inclusion and exclusion criteria were divided into two groups with the random clinical trial method, double-blind with repeated measurements. Data were analyzed statistically using t test, Mann-Whitney, Rank Spearman, Wilcoxon, t paired, and diagnostic test. The results of this study showed that the incidence of abortion in vitamin C group was 9 cases (30%) and placebo group was 13 cases (43.3%).

show abstract

Type‐1 and Type‐2 Cytokines in Human Decidual Tissue and Trophoblasts from Normal and Abnormal Pregnancies Detected by Reverse Transcriptase Polymerase Chain Reaction (RT‐PCR)

Abstract: Overall, our findings suggest that there is a balance between type-1 and type-2 cytokines during pregnancy, which is mainly characterized by the expression of IFN-gamma (a type-1 cytokine) and IL-10 (a type-2 cytokine) at the maternal fetal interface.

Cited by 45 publications

References 29 publications

The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10

The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10

The Predominant Th1 Cytokine Profile in Maternal Plasma of Preeclamptic Women Is Not Reflected in the Choriodecidual and Fetal Compartments

The Role of Antioxidant Vitamin C on Imminent Abortion through Interaction of Superoxide Dismutase, Interferon-γ, Interleukin-4, Vascular Cells Adhesion Molecule-1, and Decidual Spiral Arteries Blood Flow

Contact Info

Product

Resources

About