Type 1 diabetes, autoimmune thyroid disease, and chronic urticaria

Hyman, Sharon J.; Shreffler, Wayne G.; Rapaport, Robert

doi:10.1111/j.1399-5448.2008.00403.x

Cited by 16 publications

(13 citation statements)

References 14 publications

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“…The high frequency of TGA in individuals with T1D established in this study is in line with previous reports . The prevalence of ATPA and TPOA was lower than reported previously (18–25%) , although exceeding that in the general population by up to three times.…”

Section: Discussionsupporting

confidence: 92%

“…The high frequency of TGA in individuals with T1D established in this study is in line with previous reports [20,23,[34][35][36][37][38][39][40][41]. The prevalence of ATPA and TPOA was lower than reported previously (18-25%) [19,30,33,41,42], although exceeding that in the general population by up to TGA/CD, ATPA and TPOA 5 autoantibodies to tissue transglutaminase and/or coeliac disease, autoantibodies to H 1 /K 1 -ATPase and autoantibodies to thyroid peroxidase, respectively.…”

Section: Prevalence Of Multiple Autoimmunity In T1dsupporting

confidence: 91%

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A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study

Kozhakhmetova

Wyatt

Caygill

et al. 2018

Clinical and Experimental Immunology

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Individuals with type 1 diabetes (T1D) are at increased risk of coeliac disease (CD), autoimmune thyroiditis and autoimmune gastritis, but the absolute risks are unclear. The aim of this study was to investigate the prevalence of autoantibodies to tissue transglutaminase (TGA), thyroid peroxidase (TPOA) and gastric H /K -ATPase (ATPA) and their genetic associations in a well-characterized population-based cohort of individuals with T1D from the Bart's-Oxford family study for whom islet autoantibody prevalence data were already available. Autoantibodies in sera from 1072 patients (males/females 604/468; median age 11·8 years, median T1D duration 2·7 months) were measured by radioimmunoassays; HLA class II risk genotype was analysed in 973 (91%) using polymerase chain reaction with sequence specific primers (PCR-SSP). The prevalence of TGA (and/or history of CD), TPOA and ATPA in patients was 9·0, 9·6 and 8·2%, respectively; 3·1% had two or more autoantibodies. Females were at higher risk of multiple autoimmunity; TGA/CD were associated with younger age and TPOA with older age. ATPA were uncommon in patients under 5 years, and more common in older patients. Anti-glutamate decarboxylase autoantibodies were predictive of co-existing TPOA/ATPA. TGA/CD were associated with human leucocyte antigen (HLA) DR3-DQ2, with the DR3-DQ2/DR3-DQ2 genotype conferring the highest risk, followed by DR4-DQ8/DR4-DQ8. ATPA were associated with DR3-DQ2, DRB1*0404 (in males) and the DR3-DQ2/DR4-DQ8 genotype. TPOA were associated with the DR3-DQ2/DR3-DQ2 genotype. Almost one-quarter of patients diagnosed with T1D aged under 21 years have at least one other organ-specific autoantibody. HLA class II genetic profiling may be useful in identifying those at risk of multiple autoimmunity.

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Section: Discussionsupporting

confidence: 92%

Section: Prevalence Of Multiple Autoimmunity In T1dsupporting

confidence: 91%

A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study

Kozhakhmetova

Wyatt

Caygill

et al. 2018

Clinical and Experimental Immunology

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“…Other autoimmune cutaneous lesions like chronic urticaria 103–105 and thrombotic thrombocytopenic purpura 105 have also been reported in T1D.…”

Section: Autoimmune Cutaneous Lesionsmentioning

confidence: 97%

Juvenile, insulin‐dependent diabetes mellitus, type 1‐related dermatoses

Sehgal¹,

Bhattacharya²,

Verma³

2010

Acad Dermatol Venereol

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Juvenile insulin-dependent diabetes mellitus type 1 (IDDM) is a well-recognized worldwide entity, the significance of which has increased because of its recent upsurging trends, warranting attention on variety of its clinical expressions, in particular, pertaining to skin, an aspect seldom taken cognizance of. Hence an endeavour to recap the related dermatoses, such as limited joint mobility syndrome including sclerodermoid (scleroderma-like) changes, xerosis, necrobiosis lipoidica diabeticorum, granuloma annulare, diabetic foot syndrome, has been made. Complexities relating to the recently explored issues of atopic dermatitis and drug hypersensitivity syndrome have also been covered adequately. In addition, the current concepts of the physiopathology of type 1 diabetes-related dermatoses are briefly recapitulated for clarity.

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“…Additionally, multiple autoimmune conditions may present in the same child. Hyman et al (53) describes the case of a 12‐year‐old boy with CU and autoimmune thyroid disease who developed IDDM during thyroid hormone replacement. Although CD, JRA, and IDDM are occasionally associated with CU, they too may only identify a patient with underlying autoimmune predisposition and do not necessarily reflect causality.…”

Section: Documented Cu Associations (Unclear If Causal)mentioning

confidence: 99%

Evidence‐Based Evaluation and Management of Chronic Urticaria in Children

Zitelli

Cordoro

2011

Pediatric Dermatology

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Urticaria affects nearly 25% of the population at some time in their lives. In a subset of children, urticaria will develop into a chronic condition that can greatly affect quality of life. Although numerous causes and triggers are proposed for chronic urticaria (CU) in children, ranging from infections, allergens, and medications to physical factors and autoimmune disease, the exact etiology is not always identifiable. Accordingly, a large subset of cases are designated "chronic idiopathic urticaria." Because of the clinical complexities of CU, as well as the confusing literature on this topic, we have developed a conceptual framework based on the cumulative evidence to assist with the categorization, clinical evaluation, and treatment of CU in children.

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Type 1 diabetes, autoimmune thyroid disease, and chronic urticaria

Cited by 16 publications

References 14 publications

A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study

A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study

Juvenile, insulin‐dependent diabetes mellitus, type 1‐related dermatoses

Evidence‐Based Evaluation and Management of Chronic Urticaria in Children

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