2019
DOI: 10.1016/j.diabet.2018.08.005
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Type 1 innate lymphoid cells are associated with type 2 diabetes

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Cited by 13 publications
(18 citation statements)
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“…Additionally, the geographic distribution of the included studies comprised of Europe ( n = 6) [ 14 – 17 , 21 , 27 ], Northern America ( n = 2) [ 20 , 23 ], Africa ( n = 1) [ 24 ], and Asia ( n = 4) [ 19 , 25 , 27 , 28 ]. Two studies were longitudinal prospective studies [ 22 ] and the remaining 9 studies were cross-sectional studies [ 15 – 17 , 21 , 23 , 26 , 27 , 29 31 ]. In total, this systematic review included 1555 adult participants (491 patients with T2D and 1064 controls) (Table 1 ).…”
Section: Resultsmentioning
confidence: 99%
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“…Additionally, the geographic distribution of the included studies comprised of Europe ( n = 6) [ 14 – 17 , 21 , 27 ], Northern America ( n = 2) [ 20 , 23 ], Africa ( n = 1) [ 24 ], and Asia ( n = 4) [ 19 , 25 , 27 , 28 ]. Two studies were longitudinal prospective studies [ 22 ] and the remaining 9 studies were cross-sectional studies [ 15 – 17 , 21 , 23 , 26 , 27 , 29 31 ]. In total, this systematic review included 1555 adult participants (491 patients with T2D and 1064 controls) (Table 1 ).…”
Section: Resultsmentioning
confidence: 99%
“…NK are the major innate lymphocyte subsets that are involved in the Fig. 2 Levels of natural killer cells in patients living with T2D compared to controls regulation of inflammatory response process and possess promising clinical exploration [30,31]. The aim of this systemic review and meta-analysis was to provide a comprehensive synthesis of available studies reporting on NK cells in adult patients living with T2D.…”
Section: Discussionmentioning
confidence: 99%
“…Liu et al have demonstrated that the numbers of ILC2s as well as serum cytokine levels of IL-4, IL-5, and IL-13 are significantly elevated in diabetic kidney disease patients and have a positive correlation with disease severity (186). They further demonstrated that ILC2s, through the TGF-β1 signaling pathway, are involved in renal fibrosis seen in diabetic kidney disease (184). However, Galle-Treger et al indicated that the engagement of the glucocorticoid-induced tumor necrosis factor receptor (GITR/or TNFRSF18) on the surface of activated ILC2s promotes their secretion of IL-5 and IL-13, ameliorates glucose homeostasis, protects against the onset of and improves established insulin resistance (187).…”
Section: Innate Lymphoid Cells (Ilcs)mentioning
confidence: 99%
“…In T2DM, the numbers of circulating as well as adipose tissue-resident ILC1s are increased compared with normal individuals (184,185). The frequency of circulating ILC1s is positively correlated with fasting plasma glucose (FPG), HbA1c, homeostasis model assessment for insulin resistance (HOMA-IR), serum-free fatty acids (FFAs) and adipose tissue insulin resistance index (Adipo-IR) (184,185). It has also been shown that patients with increased numbers of ILC1 have an elevated risk of developing T2DM (184).…”
Section: Innate Lymphoid Cells (Ilcs)mentioning
confidence: 99%
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