Type-1 interferons prolong the lifespan of neutrophils by interfering with members of the apoptotic cascade

Aga, Eresso; Mukherjee, Arkajyoti; Rane, Deepti; More, Vasundhara; Patil, Tejaswini; Zandbergen, Ger van; Solbach, Werner; Dandapat, Jagneswar; Tackenberg, Heidi; Ohms, Mareike; Sarkar, Arup; Laskay, Tamás

doi:10.1016/j.cyto.2018.06.027

Cited by 14 publications

(7 citation statements)

References 18 publications

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“…Tumor-derived factors, aside from promoting a pro-tumorigenic shift in neutrophils, can also induce a phenotypic shift of infiltrating neutrophils toward an anti-tumor state [ 85 ]. At the developing stage of non-small-cell lung cancer (NSCLC), cytokines such as IFN-γ and GM-CSF are shown to drive the neutrophil differentiation towards expressing the co-stimulatory molecules CD13 (OX40) ligand, CD86, and 4-1BB ligand, specific neutrophil activation markers that promote anti-tumor activity [ 86 ].…”

Section: Neutrophil Plasticity In the Tumor Microenvironmentmentioning

confidence: 99%

Neutrophil Extracellular Traps (NETs) in Cancer Metastasis

Kaltenmeier

Simmons

Tohme

et al. 2021

Cancers

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Metastasis is the leading cause of cancer related morbidity and mortality. The metastatic process involves several identifiable biological stages, including tumor cell dissemination, intravasation, and the extravasation of circulating cancer cells to facilitate colonization at a distant site. Immune cell infiltration and inflammation within the tumor microenvironment coincide with tumor progression and metastatic spread and are thought to be the key mediators of this complex process. Amongst many infiltrating cells, neutrophils have recently emerged as an important player in fueling tumor progression, both in animal models and cancer patients. The production of Neutrophil Extracellular Traps (NETs) is particularly important in the pathogenesis of the metastatic cascade. NETs are composed of web-like DNA structures with entangled proteins that are released in response to inflammatory cues in the environment. NETs play an important role in driving tumor progression both in experimental and clinical models. In this review, we aim to summarize the current advances in understanding the role of NETs in cancer, with a specific focus on their role in promoting premetastatic niche formation, interaction with circulating cancer cells, and in epithelial to mesenchymal transition during cancer metastasis. We will furthermore discuss the possible role and different treatment options for targeting NETs to prevent tumor progression.

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Section: Neutrophil Plasticity In the Tumor Microenvironmentmentioning

confidence: 99%

Neutrophil Extracellular Traps (NETs) in Cancer Metastasis

Kaltenmeier

Simmons

Tohme

et al. 2021

Cancers

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“…al. reported that IFNα also has an anti-apoptotic effect over neutrophils, prolonging their half-life in the lesions [35].…”

Section: Discussionmentioning

confidence: 99%

A peptide derived from phage-display limits psoriasis-like lesions in mice

Zapi‑Colín

Gutiérrez-González

Rodríguez‐Martínez

et al. 2020

Heliyon

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Background: Psoriasis is a pro-inflammatory disease with unknown etiology, that is characterized by skin inflammation and keratinocytes hyperproliferation. Specific inhibition of inflammation has shown positive effects avoiding the progression of the psoriatic lesions in different animal models of the disease, turning this strategy as a remarkable therapeutic alternative. Objective: To screen the effectiveness of a novel IFN-α/β signalling inhibitor in the development reduction of skin lesions in IMQ and TPA mice models of psoriasis. Methods: We used a Phage-peptide library for the screening of a peptide with inhibitory effects on the development of psoriasis-like lesions in mice. To evaluate the in vivo effect of the phage-peptides (Phpep3D) and the derived peptide (Pep3D), we administered Phpep3D or Pep3D intradermally in mice with imiquimod (IMQ)induced psoriasis and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced psoriasis. We scored the lesions, and we determined the number of neutrophils and the production of some pro-inflammatory cytokines in the lesions. Results: In this work, we describe how the Ph3pepD and Pep3D reduced skin thickness, redness, and acanthosis despite the presence of the psoriasis inducers, IMQ or TPA. We also found that Pep3D reduced the number of GR1þ infiltrated cells and decreased the production of IL-17A and TNFα in the psoriatic skin of mice. In-silico, docking analysis showed that Pep3D may interact with the interferon-alpha receptor, but further analyses should be performed to uncover the mechanism of action of this peptide. Conclusion: Our results suggest that Pep3D could be used as a new treatment for psoriasis.

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“…61 Neutrophils in inflamed tissues may have an extended life span of several days. 62 Granulocyte-colony stimulating factor (G-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF) are two antiapoptotic cytokines that may play a role in the mechanisms of delayed apoptosis. Long-lived neutrophils can produce and secrete more cytokines, chemokines, and cytotoxic substances, which cause inflammation to continue.…”

Section: Discussionmentioning

confidence: 99%