2021
DOI: 10.1101/2021.10.18.464770
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Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14

Abstract: A key attribute of persistent or recurring bacterial infections is the ability of the pathogen to evade the host’s immune response. Many Enterobacteriaceae express type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and establish persistent infections. However, the molecular mechanisms and strategies by which bacteria actively circumvent the immune response of the host remain poorly understood. Here, we identified CD14, the major co-receptor for lipopolysaccharide detection, on dendriti… Show more

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