Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

Abstract

Objective: Gestational diabetes mellitus (GDM) is a metabolic disorder that shares pathophysiologic features with type 2 diabetes mellitus. The aim of this study was to investigate the association of the polymorphisms fat mass and obesity-associated (FTO) rs1421085, leptin receptor (LEPR) rs1137100, rs1137101, peroxisome proliferator-activated receptor gamma (PPARg) rs1801282, and transcription factor 7-like 2 (TCF7L2) rs7901695 with GDM. Subjects and methods: 252 unrelated Euro-Brazilian pregnant women were classified into two groups according to the 2015 criteria of the American and Brazilian Diabetes Association: healthy pregnant women (n = 125) and pregnant women with GDM (n = 127), matched by age. The polymorphisms were genotyped using fluorescent probes (TaqMan ® ). Results: All groups were in Hardy-Weinberg equilibrium. The genotype and allele frequencies of the studied polymorphisms did not show significant differences between the groups (P > 0.05). In the healthy and GDM groups, the C allele frequencies (95% CI) of the FTO rs1421085 polymorphism were 36.8% [31-43%]

Gestational diabetes mellitus and type 2 diabetes: same disease in a different moment of life? Maybe not

“…Some of TCF7L2 polymorphisms have been found to be associated with GDM in other populations (10)(11)(12)(13). The authors have found no relation between these polymorphisms with GDM in this Brazilian studied population (9).…”

“…evaluated the polymorphisms of several genetic variants that are associated with T2D. The authors studied gene polymorphisms T2D-related such as fat mass and obesity-associated (FTO), leptin receptor (LEPR), peroxisome proliferatoractivated receptor gamma (PPARγ), and transcription factor 7-like 2 (TCF7L2) (9). These polymorphisms are related to food intake, energy balance, appetite regulation, gene expression transcription, glucose and lipids metabolism, inflammation and proliferation of pancreatic beta cells.…”

Molecular Biomarkers for Gestational Diabetes Mellitus

“…Genetic studies of the transcription factor 7 like 2 ( TCF7L2 ) gene, which is arguably one of the most important T2D susceptibility genes [ 36 ], produced varying results in GDM [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. TCF7L2 encodes a transcription factor, which is involved in Wnt signaling, an important pathway that regulates glucose homeostasis.…”

“…One of the five studies investigating rs7901695 found an association between GDM and the T allele in American Caucasians [ 46 ], while one study found that the C allele, rather than the T allele, was associated with GDM in a large Swedish population [ 43 ]. The three studies that did not show an association had relatively small sample sizes [ 40 , 41 , 45 ]. Of the five studies investigating rs12255372, two showed an association between the T allele and GDM, one was conducted in a large Swedish population and the other in a small Mexican population [ 42 , 43 ].…”

“…Discrepancies between the studies are possibly due to ethnic and genotyping method differences. None of the studies investigating rs8050136 and rs1421085 found an association between these SNPs and GDM [ 45 , 47 , 70 ].…”