Type 2 Diabetes Mellitus in Children

Khadar, Jabbar Puthiyaveettil; Nair, Abilash

doi:10.5005/jp/books/14155_31

Cited by 2 publications

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“…Therefore, it is significant to conduct a systematic and comprehensive investigation of the current development of type 2 diabetes in adolescents and children. In addition, the developmental trends of type 2 diabetes among children and adolescents worldwide vary widely among countries, age groups and ethnic categories [6]. Some epidemiological studies show that there are many distinctions in the population distribution of T2DM among adolescents and children, such as geodemography, age, sex, race, etc.…”

Section: The Development Of T2dm In Adolescents and Childrenmentioning

confidence: 99%

“…In addition, some developed western regions show quite high prevalence rates and continue to rise in the context of continued public intervention. The incidence of T2DM in children has been increasing in the United States, Canada, the United Kingdom, etc [6]. In general, T2DM develops rapidly and widely in adolescents and children.…”

Section: The Development Of T2dm In Adolescents and Childrenmentioning

confidence: 99%

“…For example, family selfmonitoring glucose programs should be individualized, and medication management for adolescents and children should be specialized [4]. In addition, accurate diagnosis requires repeated testing, to improve diagnostic accuracy [6].…”

Section: Guides On Feasible Prevention and Interventionmentioning

confidence: 99%

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Epidemiological Surveillance of Type 2 Diabetes Among Adolescents and Children

Zhu

2023

TNS

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With a high incidence of the condition worldwide, type 2 diabetes has emerged as one of the most worrisome chronic diseases. Type 2 diabetes has been identified in certain public health research to have an early beginning tendency, and the rapid rise in teen and child prevalence may be an epidemiological warning sign. This study uses systematic retrieval and induction techniques to examine the prevalence and trajectory of type 2 diabetes in children and adoles-cents. In this paper, the useful data and literature collected are discussed and sorted out in an attempt to establish a complete field of analysis of current type 2 diabetes, which is to criti-cally discuss the practice of current epidemiological surveillance and screening systems for adolescents and children, and to propose possible constructive suggestions. This study finds that the development trend in adolescents and children may not be optimistic, and there are differences in risk based on geographic demography, gender, race, etc. Epidemiological screening and surveillance of type 2 diabetes in adolescents and children, as well as targeted public and individual prevention and intervention, could have significant implications.

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Section: The Development Of T2dm In Adolescents and Childrenmentioning

confidence: 99%

Section: The Development Of T2dm In Adolescents and Childrenmentioning

confidence: 99%

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Epidemiological Surveillance of Type 2 Diabetes Among Adolescents and Children

Zhu

2023

TNS

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Mechanisms Underlying Biological Effects of Cruciferous Glucosinolate-Derived Isothiocyanates/Indoles: A Focus on Metabolic Syndrome

Esteve

2020

Front. Nutr.

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An inverse correlation between vegetable consumption and the incidence of cancer has long been described. This protective effect is stronger when cruciferous vegetables are specifically consumed. The beneficial properties of vegetables are attributed to their bioactive components like fiber, antioxidants vitamins, antioxidants, minerals, and phenolic compounds. Cruciferous vegetables contain all these molecules; however, what makes them different are their sulfurous components, called glucosinolates, responsible for their special smell and taste. Glucosinolates are inactive biologically in the organism but are hydrolyzed by the enzyme myrosinase released as a result of chewing, leading to the formation of active derivatives such as isothiocyanates and indoles. A considerable number of in vitro and in vivo studies have reported that isothiocyanates and indoles elicit chemopreventive potency through multiple mechanisms that include modulation of phases I and II detoxification pathway enzymes, regulation of cell cycle arrest, and control of cell growth, induction of apoptosis, antioxidant activity, anti-angiogenic effects, and epigenetic regulation. Nuclear erythroid 2-related factor 2 (Nrf2) and Nuclear factor-κB (NF-κB) are key and central regulators in all these processes with a main role in oxidative stress and inflammation control. It has been described that isothiocyanates and indoles regulate their activity directly and indirectly. Today, the metabolic syndrome (central obesity, insulin resistance, hyperlipidemia, and hypertension) is responsible for a majority of deaths worldwide. All components of metabolic syndrome are characterized by chronic inflammation with deregulation of the PI3K/AKT/mTOR, MAPK/EKR/JNK, Nrf2, and NF-κB signaling pathways. The effects of GLSs derivatives controlling these pathways have been widely described in relation to cancer. Changes in food consumption patterns observed in the last decades to higher consumption of ultra-processed foods, with elevation in simple sugar and saturated fat contents and lower consumption of vegetables and fruits have been directly correlated with metabolic syndrome prevalence. In this review, it is summarized the knowledge regarding the mechanisms by which cruciferous glucosinolate derivatives (isothiocyanates and indoles) directly and indirectly regulate these pathways. However, the review places a special focus on the knowledge of the effects of glucosinolates derivatives in metabolic syndrome, since this has not been reviewed before.

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Type 2 Diabetes Mellitus in Children

Cited by 2 publications

References 0 publications

Epidemiological Surveillance of Type 2 Diabetes Among Adolescents and Children

Epidemiological Surveillance of Type 2 Diabetes Among Adolescents and Children

Mechanisms Underlying Biological Effects of Cruciferous Glucosinolate-Derived Isothiocyanates/Indoles: A Focus on Metabolic Syndrome

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