Type 2A protein phosphatase, the complex regulator of numerous signaling pathways

Zołnierowicz, Stanisław

doi:10.1016/s0006-2952(00)00424-x

Cited by 182 publications

(155 citation statements)

References 97 publications

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“…This is in agreement with our previous studies, which showed impaired AP1 activity in SLE T cells (12). PP2A could also affect AP1 activity by altering the phosphorylation status of c-fos and c-jun (64).…”

Section: Discussionsupporting

confidence: 93%

Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus

Katsiari

Kyttaris²,

Juang³

et al. 2005

Journal of Clinical Investigation

143

145

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Section: Discussionsupporting

confidence: 93%

Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus

Katsiari

Kyttaris²,

Juang³

et al. 2005

Journal of Clinical Investigation

143

145

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“…Activity of cell signaling proteins is often regulated by phosphorylation and dephosphorylation, leading to complex signaling networks. Involvement of PP2A in such networks has been extensively reviewed [11,37,40,41]. Interestingly, PP2A has been reported to regulate the PKA, the calmodulin and the ERK1/2 pathways in mammalian cells [42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Protein phosphatase 2A plays a crucial role in Giardia lamblia differentiation

Lauwaet

Davids

Torres-Escobar

et al. 2007

Molecular and Biochemical Parasitology

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The ability of Giardia lamblia to undergo two distinct differentiations in response to physiologic stimuli is central to its pathogenesis. The giardial cytoskeleton changes drastically during encystation and excystation. However, the signal transduction pathways mediating these transformations are poorly understood. We tested the hypothesis that PP2A, a highly conserved serine/threonine protein phosphatase, might be important in giardial differentiation. We found that in vegetatively growing trophozoites, gPP2A-C protein localizes to basal bodies/centrosomes, and to cytoskeletal structures unique to Giardia: the ventral disk, and the dense rods of the anterior, posterior-lateral, and caudal flagella. During encystation, gPP2A-C protein disappears from only the anterior flagellar dense rods. During excystation, gPP2A-C localizes to the cyst wall in excysting cysts but is not found in the wall of cysts with emerging excyzoites. Transcriptome and immunoblot analyses indicated that gPP2A-C mRNA and protein are upregulated in mature cysts and during the early stage of excystation that models passage through the host stomach. Stable expression of gPP2A-C antisense RNA did not affect vegetative growth, but strongly inhibited the formation of encystation secretory vesicles (ESV) and water-resistant cysts. Moreover, the few cysts that formed were highly defective in excystation.Thus, gPP2A-C localizes to universal cytoskeletal structures and to structures unique to Giardia. It is also important for encystation and excystation, crucial giardial transformations that entail entry into and exit from dormancy.

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“…Several studies have demonstrated a link between PP2A and a number of diseases (Janssens et al 2005, Rivera & Losada 2006, Krapf et al 2010, Brestovitsky et al 2011, Ruediger et al 2011. Its catalytic subunit PP2AC plays a critical role in embryonic development and human diseases, such as Alzheimer's disease, cancer, and diabetes (Goedert et al 1995, Zolnierowicz 2000, Kowluru 2005, Eichhorn et al 2009, Liu & Wang 2009). The homologues PPP2CA and PPP2CB can each function as the catalytic subunit of PP2A and are related to the male and female reproductive systems respectively.…”

Section: Introductionmentioning

confidence: 99%

Ppp2ca knockout in mice spermatogenesis

Pan¹,

Chen²,

Tong³

et al. 2015

Reproduction

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Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase involved in meiosis, mitosis, sperm capacitation, and apoptosis. Abberant activity of PP2A has been associated with a number of diseases. The homolog PPP2CA and PPP2CB can each function as the phosphatase catalytic subunit generally referred to as PP2AC. We generated a Ppp2ca conditional knockout (CKO) in C57BL/6J mice. Exon 2 of Ppp2ca was knocked out in a spatial or temporal-specific manner in primordial germ cells at E12.5. This Ppp2ca-null mutation caused infertility in male C57BL/6J mice. These CKO mice provide a powerful tool to study the mechanisms of Ppp2ca in development and disease.

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Type 2A protein phosphatase, the complex regulator of numerous signaling pathways

Cited by 182 publications

References 97 publications

Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus

Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus

Protein phosphatase 2A plays a crucial role in Giardia lamblia differentiation

Ppp2ca knockout in mice spermatogenesis

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