Type 3 Diabetes Reflects Disordered Lipid Metabolism in the Human Brain Related to Higher Degree of Unsaturated Fatty Acids Composition and is not Related to Body Mass Index

Ginneken, Vincent van; Vries, Evert de; Verheij, Elwin; Greef, J. van der

doi:10.4172/1948-593x.1000171

Cited by 1 publication

(1 citation statement)

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“…Senile plaques which are one of the characteristic hallmarks in the AD; were found to be formed in frontal and temporal lobe region of diabetic monkeys' brain at a faster pace when compared with normally aged monkeys (Okabayashi et al, ). Lipid profiling on brains of people suffering from type 2 diabetes with more than 70 years of age depicted abnormal fluctuations in lipid content to be a possible reason behind type 3 diabetes (Ginneken, Ede, Verheij, & Greef, ).…”

Section: Alzheimer's Disease As Type 3 Diabetes: a Plausible Linkmentioning

confidence: 99%

Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease

Jash

Gondaliya

Kirave

et al. 2019

Drug Development Research

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Diabetes mellitus (DM) is a gradually rising metabolic disease which is currently affecting millions of people worldwide. Diabetes is associated with various complications like nephropathy, neuropathy, retinopathy, diabetic foot, cognitive impairment, and many more. Evidence suggests that cognitive dysfunction is a rising complication of diabetes which adversely affects the brain of patients suffering from diabetes. Age‐related memory impairment is a complication having its major effect on people suffering from diabetes and Alzheimer's. Patients suffering from diabetes are at two times higher risk of developing cognitive dysfunction as compared with normal individuals. Multiple factors which are involved in diabetes related complications are found to play a role in the development of neurodegeneration in Alzheimer's. The problem of insulin deficiency and insulin resistance is well reported in diabetes but there are many studies which suggest dysregulation of insulin levels as a reason behind the development of Alzheimer's. As the link between diabetes and Alzheimer disease (AD) is deepening, there is a need to understand the plausible tie‐ins between the two. Emerging role of major factors like insulin imbalance, advanced glycation end products and micro‐RNA's involved in diabetes and Alzheimer's have been discussed here. This review helps in understanding the plausible mechanism underlying the pathophysiology of amyloid beta (Aβ) plaque formation and tau hyperphosphorylation as well provides information about studies carried out in this area of research. The final thought is to enhance the scientific knowledge on this correlation and develop future therapeutics to treat the same.

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Section: Alzheimer's Disease As Type 3 Diabetes: a Plausible Linkmentioning

confidence: 99%