Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis

Ciccia, Francesco; Guggino, Giuliana; Rizzo, Aroldo; Saieva, Laura; Peralta, Sergio; Giardina, A; Cannizzaro, Alessandra; Sireci, Guido; Leo, Giacomo De; Alessandro, Riccardo; Triolo, G

doi:10.1136/annrheumdis-2014-206323

Cited by 261 publications

(216 citation statements)

References 42 publications

Supporting

Mentioning

199

Contrasting

Unclassified

Order By: Relevance

“…More recently, gut-derived IL-17 + IL-22 + ILCs have been found expanded in the peripheral blood, synovial fluid and inflamed bone marrow of patients with AS, suggesting the presence of an active homing axis between the gut and the inflamed sacroiliac joints [40]. In addiction, the authors reported a significant decrease in the percentage of intestinal and circulating IL-17 + IL-22 + ILC and in the expression of mucosal vascular addressin cell adhesion molecule 1 (MADCAM-1) related to the TNFi treatment efficacy [40].…”

Section: Enteropathic Spa: Insights On the Pathogenesismentioning

confidence: 99%

Impact of a multidisciplinary approach in enteropathic spondyloarthritis patients

Conigliaro

Chimenti

Ascolani

et al. 2016

Autoimmunity Reviews

View full text Add to dashboard Cite

Spondyloarthritis (SpA) and inflammatory bowel disease (IBD) are chronic autoinflammatory diseases that partially share the genetic predisposition and the unchecked inflammatory response linking the gut to the joints. The coexistence of both conditions in patients and the increased cross-risk ratios between SpA and IBD strongly suggest a shared pathophysiology. The prevalence of Enteropathic-related Spondyloarthritis (ESpA) in IBD patients shows a wide variation and may be underestimated. It is well accepted that the management of joint pain requires rheumatological expertise in conjunction with gastroenterologist assessment. In this view, we aimed at assessing, in a prospective study performed in a combined Gastro-Intestinal and Rheumatologic "GI-Rhe" clinic: (1) the prevalence of ESpA and other rheumatologic diseases in IBD patients with joint pain; (2) the features of the ESpA population; and (3) the diagnostic delay and the potential impact of the combined assessment. From November 2012 to December 2014, IBD patients with joint pain referring to a dedicated rheumatologist by the IBD-dedicated gastroenterologist were enrolled. Clinical and biochemical evaluations, joint involvement and disease activity assessment, diagnostic delay, and treatment were recorded. IBD patients (n = 269) with joint pain were jointly assessed in the "GI-Rhe" Unit. A diagnosis of ESpA was made in 50.5% of IBD patients with joint pain. ESpA patients showed a peripheral involvement in 53% of cases, axial in 20.6% and peripheral and axial in 26.4% of cases. ESpA patients had a higher prevalence of other autoimmune extra-intestinal manifestations and received more anti-TNF treatment compared with IBD patients. A mean diagnostic delay of 5.2 years was revealed in ESpA patients. Patients with joint disease onset in the 2002-2012 decade had reduced diagnostic delay compared with those with onset in the 1980-1990 and 1991-2001 decades. Diagnostic delay was further reduced for patients with joint onset in the last two years in conjunction with the establishment of the GI-Rhe clinic. Multidisciplinary approach improved management of rheumatic disorders in IBD patients allowing a more comprehensive care.

show abstract

Section: Enteropathic Spa: Insights On the Pathogenesismentioning

confidence: 99%

Impact of a multidisciplinary approach in enteropathic spondyloarthritis patients

Conigliaro

Chimenti

Ascolani

et al. 2016

Autoimmunity Reviews

View full text Add to dashboard Cite

show abstract

“…Cryptopatches are virtually absent in the ileum of normal subjects [37], suggesting that bacterial stimulation is necessary for them to develop in physiological conditions. Conversely, in the ileum of AS patients, increased expression of IL-7, mainly in the presence of PC, is associated with the presence of aggregates of LTi cells (CD3-c-kitþ/IL-7Rþ) that resemble murine cryptopatches [37] (Fig.…”

Section: Immune Alterations In the Gut Of Spa Patientsmentioning

confidence: 99%

“…2). In addition to their role in modulating the formation of cryptopatches, AS intestinal epithelial cells induce the differentiation of type III innate lymphoid cells (ILCs) [37]. ILCs are heterogeneous populations of lymphoid cells that do not display rearrangement of antigen receptors [38].…”

Section: Immune Alterations In the Gut Of Spa Patientsmentioning

confidence: 99%

“…In the light of these facts, modulation of ILC3 trafficking might be useful as a therapeutic strategy in AS. It is interesting to note that anti-TNF therapy, a well established anti-inflammatory therapy in AS, results in systemic and intestinal reduction of ILC3 and in strong reduction of intestinal expression of MAdCAM1 [37]. Mucosal-associated invariant T (MAIT) cellsda novel innate-like T-cell population, recognizing a highly conserved antigen derived from the microbial riboflavin synthesis pathway [40]dhave been recently implicated in the pathogenesis of AS.…”

Section: Immune Alterations In the Gut Of Spa Patientsmentioning

confidence: 99%

See 1 more Smart Citation

The role of the gastrointestinal tract in the pathogenesis of rheumatic diseases

Ciccia

Ferrante

Guggino

et al. 2016

Best Practice & Research Clinical Rheumatology

Self Cite

View full text Add to dashboard Cite

a b s t r a c tDysregulation of the intestinal epithelial barrier in genetically susceptible individuals may lead to both intestinal and extraintestinal autoimmune disorders. There is emerging literature on the role of microbiota changes in the pathogenesis of systemic rheumatic diseases such as rheumatoid arthritis, spondyloarthropathies, and connective tissue diseases. Although the role of the gastrointestinal tract in the pathogenesis of spondyloartropathies is well defined and many studies underline the importance of gastrointestinal inflammation in modulating local and systemic inflammation, the data are inconclusive regarding the effect of dysbiosis on rheumatoid arthritis and connective tissue diseases. This review aims to summarize current data on the role of the gastrointestinal involvement and intestinal microbiota in the pathogenesis of systemic rheumatic disease.

show abstract

“…Additionally, some immunological pathways may be actively involved in the transition of autoimmunity from the intestinal mucosa to the joint: Citrullinated immune complex formation deposition, shared antigenic targets (tTg) in the joint or intestinal (PAD), gut-joint epitope spreading, and migration of activated effector T cells from the gut to the joints, mimicking mucosal vaccine's effects on remote organs. Very recently, citrullination of the epithelial neutrophilactivating peptide 78/CXCL5 chemokine, resulted in activation of the monocyte-recruiting chemokine [52]. In fact, epithelial neutrophilactivating peptide 78/CXCL5 is expressed in intestinal inflammation, citrulline is preferentially synthesized in the gut epithelium and PADs reside in the local microbiome and the intestinal mucosa.…”

Section: Gut-joint Axismentioning

confidence: 99%

GUT-the Trojan Horse in Remote Organs’ Autoimmunity

T¹

2016

J Clin Cell Immunol

View full text Add to dashboard Cite

Human beings assemble and maintain a diverse but host-specific gut microbial community along the longitudinal axis of the intestines. Helped by a functional tight junction, the default response to commensal microbes is tolerance, whereas the default response to pathogens is an intricately orchestrated immune response, resulting in pathogen clearance. Nutrients and industrial food additives were suggested to impact the intestinal ecosystem and to breach tight junction integrity. Taken together, certain nutritional components, increased intestinal permeability, disease specific dysbiotic pathobionts and their capacity of post translation modification of proteins, are luminal events that impact autoimmunogenesis. The present review expands on the multi gut originated axes and their relationship to remote organ autoimmune diseases. Brain, joint, bone, endocrine, liver, kidney, heart, lung and skin autoimmune diseases are connected to the intestinal luminal compartmental deregulated events to form the gut-systemic organs axes.

show abstract

Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis

Cited by 261 publications

References 42 publications

Impact of a multidisciplinary approach in enteropathic spondyloarthritis patients

Impact of a multidisciplinary approach in enteropathic spondyloarthritis patients

The role of the gastrointestinal tract in the pathogenesis of rheumatic diseases

GUT-the Trojan Horse in Remote Organs’ Autoimmunity

Contact Info

Product

Resources

About