Type D (distressed) personality is associated with poor quality of life and mental health among 3080 cancer survivors

Mols, Floortje; Thong, Melissa S. Y.; Poll‐Franse, Lonneke V. van de; Roukema, Jan A.; Denollet, Johan

doi:10.1016/j.jad.2011.08.034

Cited by 79 publications

(77 citation statements)

References 33 publications

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“…In our sample the proportion of type D personality was 27%, while in a study from the Netherlands, Mols et al [18] reported 17% (p ¼ 0.03). This difference may be due to sampling differences, but another explanation could be the significant differences in time since diagnosis (mean 4.5 years in their sample and 12.5 years in ours).…”

Section: Patterns Of Employmentcontrasting

confidence: 67%

Pattern of employment and associated factors in long-term lymphoma survivors 10 years after high-dose chemotherapy with autologous stem cell transplantation

et al. 2016

Acta Oncologica

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Background This study examined employment patterns and associated factors in lymphoma survivors treated with high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT) from diagnosis to a follow-up survey at a mean of 10 years after HDT-ASCT. Patients and methods All lymphoma survivors aged 18 years at HDT-ASCT in Norway from 1987 to 2008, and alive at the end of 2011 were eligible for this cross-sectional study performed in 2012/ 2013. Participants completed a mailed questionnaire. Job status was dichotomized as either employed (paid work) or not-employed (disability and retirement pension, on economic support, home-makers, or students). Results The response rate was 78%, and the sample (N ¼ 312) contained 60% men. Mean age at HDT-ASCT was 44.3 and at survey 54.0 years. At diagnosis 85% of survivors were employed, 77% before and 77% after HDT-ASCT, and 58% at follow-up. Forty seven percent of the survivors were employed at all time points. The not-employed group at survey was significantly older and included significantly more females than the employed group. No significant between-group differences were observed for lymphoma-related variables. Fatigue, mental distress and type D personality were significantly higher among those not-employed, while quality of life was significantly lower compared to the employed group. Older age at survey, being female, work ability and presence of type D personality remained significantly related to being not-employed at survey in the multivariable analysis. Conclusions Our findings show that not-employed long-term survivors after HDT-ASCT for lymphoma have more comorbidity, cognitive problems and higher levels of anxiety/depression than employed survivors. These factors should be checked and eventually treated in order to improve work ability.

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Section: Patterns Of Employmentcontrasting

confidence: 67%

Pattern of employment and associated factors in long-term lymphoma survivors 10 years after high-dose chemotherapy with autologous stem cell transplantation

et al. 2016

Acta Oncologica

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“…It is well-known that suffering from cancer and additionally undergoing cancer treatment has a major impact on patients' lives, with the majority of cancer patients experiencing psychological problems, such as feelings of anxiety, fatigue and depression [23,24]. Moreover, one in 5 cancer patients have a Type D personality [25]. Hence, cancer patients may have an increased risk for onset CVD by these elevated levels of psychological distress after cancer diagnosis alone.…”

Section: Psychological Distress (D)mentioning

confidence: 99%

“…Moreover, one in 5 cancer patients have a Type D personality [25]. Hence, cancer patients may have an increased risk for onset CVD by these elevated levels of psychological distress after cancer diagnosis alone.…”

Section: Psychological Distress (D)mentioning

confidence: 99%

Cardiovascular co-morbidity in cancer patients: the role of psychological distress

et al. 2016

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Due to aging of the population and cardiotoxic cancer treatment, there is an increasing group of patients with cancer and co-morbid cardiovascular disease (CVD). In order to find a balance between the risk of undertreating the malignancy on the one hand and inducing CVD on the other hand, CVD risk stratification at the time of cancer diagnosis and knowledge on the pathway for developing incident CVD in cancer patients is vital. In this paper, we propose an adapted multiple-hit hypothesis for developing CVD in cancer patients describing that patients with cancer are exposed to a series of sequential or concurrent events that together make them more vulnerable to reduced cardiovascular reserves, development of incident CVD and ultimately death. We highlight the possible impact of psychological distress secondary to a cancer diagnosis and/or treatment, which in turn may increase the risk of incident CVD in patients diagnosed with cancer. Furthermore, we discuss potential behavioral and pathophysiological mechanisms underlying the link between psychological distress and the pathophysiology of incident CVD. In addition, key unanswered questions for future research are posed. In the future, researching the adapted multiple-hit hypothesis for developing CVD among cancer patients will hopefully advance the care of cancer patients by finding some of the missing pieces of the puzzle. To do so, we need to focus on minimizing cardiovascular risk and promoting cardiovascular health in cancer patients by addressing the knowledge gaps formulated in this paper.Keywords: Cancer, Survivors, Cardiovascular, Psychological distress, Mechanisms Cardiovascular co-morbidity in cancer patientsDue to aging of the population, there is an increasing number of patients with cancer and co-morbid cardiovascular disease (CVD). Additionally, cancer patients may develop incident CVD as a result of the cardiotoxicity of cancer treatment. Fortunately, there has been increasing awareness of co-morbid CVD in cancer patients. In 2009, the International CardiOncology Society (ICOS) was established [1]. ICOS advocates a multi-disciplinary effort to combat CVD in cancer patients by both training oncologists and cardiologists and conducting multidisciplinary research. In 2014, during the international colloquium on cardio-oncology, ICOS stressed the importance of finding a balance between the risk of undertreating the malignancy on the one hand and inducing CVD by overtreating on the other hand [2]. In order to accomplish this goal, they emphasize the importance of CVD risk stratification at the time of cancer diagnosis. Recommendations based on consensus have also been published to target the vulnerable cancer patient population, emphasizing the importance of a thorough cardiac evaluation, including the assessment of risk factors, prior to formulating a cancer treatment plan [3].Adapted multiple-hit hypothesis: the impact of psychological distress Important in CVD risk stratification is knowledge of the pathway for developing CVD in cancer patie...

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“…All individuals diagnosed with endometrial or colorectal cancer (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007), thyroid cancer (1990-2008), Hodgkin or non-Hodgkin lymphoma, or multiple myeloma (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008) were eligible for participation. Details of sample selection for the survivorship studies are reported elsewhere [30][31][32][33].…”

Section: Setting and Participantsmentioning

confidence: 99%

Variation in fatigue among 6011 (long-term) cancer survivors and a normative population: a study from the population-based PROFILES registry

Husson

Mols

Poll-Franse

et al. 2015

Support Care Cancer

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Fatigue levels are substantial in (long-term) cancer survivors and vary depending on cancer type, time since diagnosis, age, gender, treatment with chemotherapy, number of comorbid conditions, educational level, and partnership. Since significantly more cancer survivors feel fatigued in comparison with the normative population, appropriate information, assessment, and interventions for fatigue are needed during or after oncologic treatment. Furthermore, focus on better control or management of comorbid conditions of cancer survivors is recommended.

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Type D (distressed) personality is associated with poor quality of life and mental health among 3080 cancer survivors

Abstract: Cancer survivors with a Type D personality are at increased risk of impaired QoL and mental health problems that cannot be explained by socio-demographic or clinical characteristics.

Cited by 79 publications

References 33 publications

Pattern of employment and associated factors in long-term lymphoma survivors 10 years after high-dose chemotherapy with autologous stem cell transplantation

Pattern of employment and associated factors in long-term lymphoma survivors 10 years after high-dose chemotherapy with autologous stem cell transplantation

Cardiovascular co-morbidity in cancer patients: the role of psychological distress

Variation in fatigue among 6011 (long-term) cancer survivors and a normative population: a study from the population-based PROFILES registry

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