Type I Herpes Simplex Esophagitis with Concomitant Esophageal Moniliasis

Simultaneous Herpetic and Candidal Esophagitis in an Immunocompetent Teenager

“…Histologic demonstration of intranuclear inclusions in epithelial cells or multinucleated giant cells with ground glass appearing nuclei is occasionally found in the biopsies of patients with herpes esophagitis (7,9,14). Ideally, to confirm the presence of invasive candidal esophagitis, Candida spp.…”

“…is rare. A few cases have been described, mainly in adults with sepsis or malignancies receiving radiation or chemotherapy (7‐10). Hemstreet et al described the only pediatric case of esophagitis associated with two pathogens (11).…”

Herpes simplex esophagitis after renal transplantation

“…Although it has not been supported by serial endoscopic studies in individual patients, this progression of the lesions could explain the variability of the findings [6], as peptic-like inflammation [16], small discrete ulcers [15], volcano ulcers [l, 71, multiple coalescent ulcers, and pseudomembraneous esophagitis have all been described [HI. This variability is compounded by the fact that other opportunistic microorganisms, mostly cytomegalovirus and Cundidu [24], can also cause esophagitis in immunocompromised patients, either alone or in combination [3,51. Biopsies should, therefore, be taken in such cases for histological examination, viral cultures and, ideally, immunohistochemistry.…”