Type II deiodinase polymorphism: A potential risk factor of type 2 diabetes mellitus

Abstract

Type 2 diabetes mellitus (T2DM) remains one of the most challenging global epidemics of the twenty-fi rst century. It is estimated that more than 350 million people worldwide are affected by this metabolic disorder. It has many risk factors. Several studies presume that type II iodothyronine deiodinase polymorphism Thr92Ala (DII-Thr92-Ala, rs225014) is yet another risk factor. The aim of the study was to assess the impact of this polymorphism on parameters of glycid metabolism. Our group consisted of 200 subjects (74 males and 126 females) at average age of 63.85 ± 18.98 without prediabetes, diabetes mellitus or any thyropathy. Blood tests were performed to evaluate glucose metabolism parameters as well as DII-Thr92Ala polymorphism. Our study confi rmed the relationship between Ala homozygotes and glycosylated haemoglobin (HbA 1c) serum levels (Tab. 2, Ref. 14).

Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers

“…This polymorphism was demonstrated to have an impact on TH levels and therefore may influence on a variety of clinical aspects as well as the quality of life or cognition. DIO2 SNP rs205014 has been so far associated with symptomatic osteoarthritis 20 , 21 , type 2 diabetes mellitus 22 , atherosclerosis 23 , and bone mineral density 24 demonstrating the C allele as a risk factor. On the other hand, inversely to our results, the C allele at rs225014 was protective in response to lung injury 25 .…”

The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Higher Body Mass Index and Fasting Glucose Levels: A Systematic Review and Meta‐Analysis

“…Thirty articles remained after examining the titles and abstracts. Then, we assessed these articles in more detail by careful full-text examination, and six articles (seven studies) were ultimately included [13,[19][20][21][22][23], of which van der Deure et al analyzed the impact of Thr92Ala polymorphism on hypertension risk in two separate populations [23]. Although Kang et al compared the differences in fasting glucose and fasting insulin levels between different genotypes, we did not include the above data because diabetes patients were not excluded.…”

“…Four studies were included in the meta-analysis between Thr92Ala and BMI [19][20][21][22]. In total, 2,254 subjects with Thr/Thr, 3200 subjects with Thr/Ala, and 1148 subjects with Ala/Ala were included.…”

“…Glycemic Traits. As shown in Figures 3 and 4, four [13,19,21,22] studies were included when fasting glucose or fasting insulin levels were analyzed.…”

Generación de un modelo clinico-genético durante el embarazo para la predicción temprana de glicemia alterada.

“…Se ha propuesto que el polimorfismo rs225014, cuyas frecuencias alélicas se presentan en la Tabla 5, genera un cambio en la secuencia aminoacídica de treonina (Thr) a una alanina (Ala) en el codón 92 (Thr92Ala) (Estivalet et al, 2011). Esta variación ha sido asociada con los niveles de hemoglobina glicosilada (HbA1c) en pacientes sin alteración de la glicemia (Sotak et al, 2018), como también en aquellos que cursaban con DMT2 . También la variante genética se relaciona con un mayor riesgo de DMT2 (OR: 1,18) en un metaanálisis (Dora et al, 2010).…”