Type of Compound Index

Hill, R. A.; Makin, H. L. J.; Kirk, D. N.; Murphy, G. M.; MacDonald, Frank M.

doi:10.1007/978-1-4899-3310-2_4

Cited by 2 publications

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“…Within this diverse landscape, organometallic steroids or steroids containing semi-metals stand out as a remarkable class of chemical compounds. These compounds, which are not found in nature, are exclusively synthesized, resulting in a vast array of chemical structures [265][266][267][268][269][270][271][272][273][274]. The concept of organometallic steroids was introduced in the mid-1950s by pioneering groups of scientists [274].…”

Section: Organometallic Steroids: a Unique Class Of Synthetic Compoundsmentioning

confidence: 99%

“…These compounds, which are not found in nature, are exclusively synthesized, resulting in a vast array of chemical structures [265][266][267][268][269][270][271][272][273][274]. The concept of organometallic steroids was introduced in the mid-1950s by pioneering groups of scientists [274]. Over time, approximately 1000 synthetic organometallic steroids and their derivatives have been identified [265,274].…”

Section: Organometallic Steroids: a Unique Class Of Synthetic Compoundsmentioning

confidence: 99%

“…The concept of organometallic steroids was introduced in the mid-1950s by pioneering groups of scientists [274]. Over time, approximately 1000 synthetic organometallic steroids and their derivatives have been identified [265,274].…”

Section: Organometallic Steroids: a Unique Class Of Synthetic Compoundsmentioning

confidence: 99%

“…Biological activities of steroids bearing tellurium atom(268)(269)(270)(271)(272)(273)(274)(275)(276)(277)(278)(279)(280) [260].Figure 44. 3D graph illustrating the predicted and calculated activity of steroids bearing tellurium atom (271, 272, 274, 275, and 294) with a maximum of over 96% confidence, which can be used to treat Alzheimer's, Parkinson's, and other neurodegenerative diseases.…”

mentioning

confidence: 99%

“…Biological activities of steroids bearing tellurium atom(268)(269)(270)(271)(272)(273)(274)(275)(276)(277)(278)(279)(280) [260].…”

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confidence: 99%

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Steroids Bearing Heteroatom as Potential Drugs for Medicine

Dembitsky

2023

Biomedicines

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Heteroatom steroids, a diverse class of organic compounds, have attracted significant attention in the field of medicinal chemistry and drug discovery. The biological profiles of heteroatom steroids are of considerable interest to chemists, biologists, pharmacologists, and the pharmaceutical industry. These compounds have shown promise as potential therapeutic agents in the treatment of various diseases, such as cancer, infectious diseases, cardiovascular disorders, and neurodegenerative conditions. Moreover, the incorporation of heteroatoms has led to the development of targeted drug delivery systems, prodrugs, and other innovative pharmaceutical approaches. Heteroatom steroids represent a fascinating area of research, bridging the fields of organic chemistry, medicinal chemistry, and pharmacology. The exploration of their chemical diversity and biological activities holds promise for the discovery of novel drug candidates and the development of more effective and targeted treatments.

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Section: Organometallic Steroids: a Unique Class Of Synthetic Compoundsmentioning

confidence: 99%

Section: Organometallic Steroids: a Unique Class Of Synthetic Compoundsmentioning

confidence: 99%

Section: Organometallic Steroids: a Unique Class Of Synthetic Compoundsmentioning

confidence: 99%

mentioning

confidence: 99%

“…Biological activities of steroids bearing tellurium atom(268)(269)(270)(271)(272)(273)(274)(275)(276)(277)(278)(279)(280) [260].…”

mentioning

confidence: 99%

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Steroids Bearing Heteroatom as Potential Drugs for Medicine

Dembitsky

2023

Biomedicines

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Fascinating Furanosteroids and Their Pharmacological Profile

Dembitsky

2023

Molecules

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This review article delves into the realm of furanosteroids and related isoprenoid lipids derived from diverse terrestrial and marine sources, exploring their wide array of biological activities and potential pharmacological applications. Fungi, fungal endophytes, plants, and various marine organisms, including sponges, corals, molluscs, and other invertebrates, have proven to be abundant reservoirs of these compounds. The biological activities exhibited by furanosteroids and related lipids encompass anticancer, cytotoxic effects against various cancer cell lines, antiviral, and antifungal effects. Notably, the discovery of exceptional compounds such as nakiterpiosin, malabaricol, dysideasterols, and cortistatins has revealed their potent anti-tuberculosis, antibacterial, and anti-hepatitis C attributes. These compounds also exhibit activity in inhibiting protein kinase C, phospholipase A2, and eliciting cytotoxicity against cancer cells. This comprehensive study emphasizes the significance of furanosteroids and related lipids as valuable natural products with promising therapeutic potential. The remarkable biodiversity found in both terrestrial and marine ecosystems offers an extensive resource for unearthing novel biologically active compounds, paving the way for future drug development and advancements in biomedical research. This review presents a compilation of data obtained from various studies conducted by different authors who employed the PASS software 9.1 to evaluate the biological activity of natural furanosteroids and compounds closely related to them. The utilization of the PASS software in this context offers valuable advantages, such as screening large chemical libraries, identifying compounds for subsequent experimental investigations, and gaining insights into potential biological activities based on their structural features. Nevertheless, it is crucial to emphasize that experimental validation remains indispensable for confirming the predicted activities.

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Type of Compound Index

Cited by 2 publications

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Steroids Bearing Heteroatom as Potential Drugs for Medicine

Steroids Bearing Heteroatom as Potential Drugs for Medicine

Fascinating Furanosteroids and Their Pharmacological Profile

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