Type of E-Cigarette Device Used Among Adolescents and Young Adults: Findings From a Pooled Analysis of Eight Studies of 2166 Vapers

Barrington‐Trimis, Jessica L.; Gibson, Laura; Halpern‐Felsher, Bonnie; Harrell, Melissa B.; Kong, Grace; Krishnan‐Sarin, Suchitra; Leventhal, Adam M.; Loukas, Alexandra; McConnell, Rob; Weaver, Scott R.

doi:10.1093/ntr/ntx069

Cited by 67 publications

(54 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, key markers to be noted of this system are (1) the cotinine levels found in the plasma of our e‐cigarette–exposed mice (average of 53.97 ng/mL) overlaps with those observed in established human and animal e‐cigarette exposure models46, 47, 48 but undetectable in clean air samples, (2) which were obtained/observed using a device and an e‐liquid mixture that are widely used by humans34, 35, 36, 73 and (3) under real‐life puffing topography experimental conditions. 24–33 …”

Section: Discussionsupporting

confidence: 56%

“…As for the e‐cigarette device utilized for the inhalation system, we used the SMOK TFV4 Mini Tanks, and the settings were 5 V for voltage, 0.4 ohm for resistance, and 1 L/min for flow rate, all of which resemble common e‐cigarette devices 34, 35. The e‐liquid selected for our experiments was one of the top sellers,36 namely, the Vapor Chief (18 mg/mL nicotine content).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Short‐Term E‐Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice

Qasim

Karim

Silva‐Espinoza

et al. 2018

JAHA

100

View full text Add to dashboard Cite

BackgroundCardiovascular disease is the main cause of death in the United States, with smoking being the primary preventable cause of premature death, and thrombosis being the main mechanism of cardiovascular mortality in smokers. Due to the perception that electronic/e‐cigarettes are “safer/less harmful” than conventional cigarettes, their usage—among a variety of ages—has increased tremendously during the past decade. Notably, there are limited studies regarding the negative effects of e‐cigarettes on the cardiovascular system, which is also the subject of significant debate.Methods and ResultsWe employed a passive e‐VapeTM vapor inhalation system and developed an in vivo whole‐body e‐cigarette mouse exposure protocol that mimics real‐life human exposure scenarios/conditions and investigated the effects of e‐cigarettes and clean air on platelet function and thrombogenesis. Our results show that platelets from e‐cigarette–exposed mice are hyperactive, with enhanced aggregation, dense and α granule secretion, activation of the αIIbβ3 integrin, phosphatidylserine expression, and Akt and ERK activation, when compared with clean air–exposed platelets. E‐cigarette–exposed platelets were also found to be resistant to inhibition by prostacyclin, relative to clean air. Furthermore, the e‐cigarette–exposed mice exhibited a shortened thrombosis occlusion and bleeding times.ConclusionsTaken together, our data demonstrate for the first time that e‐cigarettes alter physiological hemostasis and increase the risk of thrombogenic events. This is attributable, at least in part, to the hyperactive state of platelets. Thus, the negative health consequences of e‐cigarette exposure should not be underestimated and warrant further investigation.

show abstract

Section: Discussionsupporting

confidence: 56%

Section: Methodsmentioning

confidence: 99%

Short‐Term E‐Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice

Qasim

Karim

Silva‐Espinoza

et al. 2018

JAHA

100

View full text Add to dashboard Cite

show abstract

“…Currently, there are many varieties of e-cigarette devices available with thousands of flavors [62]. Furthermore, a recent study indicates that the use of disposable/cigalike devices are less common among adolescents, whereas later generation devices, such as rechargeable, pen-like devices, mods/mech-modes are more common [63]. Thus, future research needs to consider the use of different device types and focus on later generation devices that adolescents may be more familiar with to obtain more accurate estimates of use.…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in U.S. Adolescent E-Cigarette Use

2017

Self Cite

View full text Add to dashboard Cite

Purpose of Review This study aims to review the recent (2012–2017) available gender difference data on e-cigarette use among adolescents. Recent Findings E-cigarettes are the most commonly used tobacco product among adolescents, and recent study findings showed that e-cigarette use can lead to cigarette smoking. However, gender differences in e-cigarette use among adolescents are relatively unknown. Summary We used the search terms “adolescents” and “e-cigarettes” on PubMed and identified 652 articles. Of these, 16 articles (2.5%) examined gender differences in adolescent e-cigarette use. Boys appear to have greater use of e-cigarettes, but girls may be at increased risk if e-cigarettes are targeted to them, as it has been for cigarettes. Data on gender differences are limited, and future research should continue to examine gender differences in e-cigarette use. Trends in use rates could evolve with new regulations and innovations in e-cigarette marketing and product features.

show abstract

“…There are a considerable number of nicotine vaping products (NVPs, also called e-cigarettes or vaporizers) available to consumers, with nicotine-containing liquids used by the vast majority of adult consumers. Nicotine delivery is likely to affect ease of substitution for cigarettes in nicotine dependent smokers and as a result is likely to affect smoking cessation and patterns of use, such as dual use and longterm use [1][2][3][4][5]. The kind of NVPs people use, levels of overall use and whether they use with nicotine is likely to be affected by the regulatory environment.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of nicotine vaping products used by participants in the 2016 ITC Four Country Smoking and Vaping Survey

et al. 2019

View full text Add to dashboard Cite

Background and Aims The regulatory environment for nicotine vaping products (NVPs) varies widely across countries and this will probably affect the devices used, nicotine content and usage, and hence the ability of NVPs to substitute for cigarettes. We aimed to describe the types of NVPs used by current vapers in four countries with varying regulatory and enforcement approaches toward the marketing and sale of NVPs. Methods Data are from wave 1 (July-November 2016) of the ITC Four Country Smoking and Vaping Survey (4CV1), conducted among a cohort of current and former smokers, and current NVP users (n = 5147 adults; ≥ 18 years) in Australia (AU), Canada (CA), England (EN) and the United States (US) reporting either current daily, weekly or occasional NVP use. Devices were described by type, brand, voltage variability and refill capacity. Refill solutions were described by flavour and nicotine content. Descriptive statistics and bivariate analyses were conducted on the overall sample and stratified by country. A multinomial logistic regression examined factors associated with device preference across the whole sample. Results The types of NVPs used differed by pattern of use and country. Exclusive, daily vapers were more likely to use refillable pen-shaped devices [odds ratio (OR) = 10.0] or refillable box-shaped devices (OR = 5.4) than disposable cigalike devices, when compared with other (non-daily/dual) users. Nearly all respondents reported using flavoured NVPs, fruit (28.3%) being the most common flavour. Refillable devices were the most popular: refillable box-shaped devices were more commonly reported by vapers in AU (36.8%) and US (31.4%), whereas in EN (47.4%) and CA (29.7%), vapers more often reported using refillable pen-style devices. Most users also reported that their products contained nicotine, even in CA (87.8%) and AU (91.2%), where vaping products containing nicotine were technically illegal. Conclusions In Australia, Canada, England and the United States in 2016, refillable nicotine vaping products were the most common type of nicotine vaping products used by daily vapers. Most daily vapers reported using flavoured e-liquids/refills (with variance across countries) and most reported using products that contain nicotine, even where vaping products with nicotine were banned.

show abstract

Type of E-Cigarette Device Used Among Adolescents and Young Adults: Findings From a Pooled Analysis of Eight Studies of 2166 Vapers

Cited by 67 publications

References 20 publications

Short‐Term E‐Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice

Short‐Term E‐Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice

Gender Differences in U.S. Adolescent E-Cigarette Use

Characteristics of nicotine vaping products used by participants in the 2016 ITC Four Country Smoking and Vaping Survey

Contact Info

Product

Resources

About